| Destavo Ltd | Wholesale & retail | 2022 |
| Destination Southampton Conference Bureau Limited | Administrative & support | 2017 |
| Destiny Accommodation Ltd | Real estate | 2024 |
| Desty Marine International Limited | Manufacturing | 2011 |
| Detailed Drawing Ltd | Manufacturing | 2014 |
| Detailed Sprayworkz Ltd | Construction | 2025 |
| DEU Chakar Community Interest Company | Professional & scientific | 2020 |
| DEV Recruitment Ltd | Administrative & support | 2021 |
| Devall Law Limited | Professional & scientific | 2007 |
| Develocity Ltd | Administrative & support | 2023 |
| Developing Commercial Ltd | Professional & scientific | 2019 |
| Development House Limited | Construction | 2006 |
| Development Matters Ltd | Construction | 2023 |
| Developmentally LLP | | 2015 |
| Develorex Ltd | Real estate | 2025 |
| Dever Valley Ltd | Wholesale & retail | 2015 |
| Devi Investments Limited | Real estate | 2002 |
| Device Access UK Ltd | Professional & scientific | 2010 |
| Devise Marketing Limited | Administrative & support | 2019 |
| Devmindai Holdings Limited | Information & communication | 2025 |
| Devocat Limited | Construction | 2026 |
| Devoke Europe Ltd | Wholesale & retail | 2019 |
| Devon and Cornwall Childcare Ltd | Administrative & support | 2020 |
| Devon Rose Estates Limited | Real estate | 2007 |
| Devonshire Investment Estates,(The) | Real estate | 1922 |
| Devoted Developments Ltd | Construction | 2015 |
| Devoted Films Limited | Information & communication | 2018 |
| Devxceed Ltd | Education | 2025 |
| Dext Limited | Professional & scientific | 1986 |
| Dexter Farms Limited | Agriculture & fishing | 2026 |
| DEZ Toys and Games Ltd | Wholesale & retail | 2026 |
| Dezign-Ideaz Ltd | Professional & scientific | 2016 |
| DF ALL Round Services Ltd | Transport & logistics | 2026 |
| DF Mechanical Limited | Manufacturing | 2012 |
| DF Waste Collections Ltd | Water & waste | 2026 |
| Dfbg Limited | Real estate | 2018 |
| DFC Delivery Ltd | Transport & logistics | 2025 |
| DFC Properties Limited | Real estate | 1998 |
| DFD Souls Limited | Wholesale & retail | 2025 |
| DFI Capital Ltd | Transport & logistics | 2026 |
| DG Cars Ltd | Transport & logistics | 2023 |
| DG Cleaning Solutions Ltd | Administrative & support | 2015 |
| DG Food Services Ltd | Hospitality | 2025 |
| DG Pipe Services Limited | Other services | 2010 |
| DG Recruitment Limited | Administrative & support | 2019 |
| Dg&D Wheels Ltd | Transport & logistics | 2024 |
| Dgledgers Ltd | Professional & scientific | 2020 |
| DGP Training South Limited | Education | 2019 |
| Dgsa Limited | Professional & scientific | 2016 |
| DH1 Consultancy Ltd | Administrative & support | 2022 |
| Dhaba 59 Ltd | Hospitality | 2018 |
| Dhaba 59 Sports Bar Ltd | Hospitality | 2020 |
| Dhaba Social Ltd | Hospitality | 2024 |
| Dhaliwal Food Store Limited | Wholesale & retail | 2020 |
| Dhankartaji S/Testing Services Ltd | Professional & scientific | 2019 |
| Dhcarpets & Flooring Limited | Construction | 2024 |
| DHI Water Environments (UK) Ltd | Professional & scientific | 2011 |
| Dhillon Assets Limited | Real estate | 2020 |
| Dhillon Homes & Apartments Ltd | Real estate | 2019 |
| Dhimahi Ltd | Wholesale & retail | 2009 |
| Dhiya Investments Ltd | Real estate | 2024 |
| Dhiya Ltd | Wholesale & retail | 2017 |
| Dhruti Dabhi Ltd | Public administration | 2024 |
| DHS Group Ltd | Financial services | 2026 |
| DHS Property Group Ltd | Real estate | 2022 |
| DHS Recruitment Ltd | Administrative & support | 2017 |
| DHS Supported Living Services Ltd | Health & social care | 2020 |
| Di-Nur Ltd | Other services | 2025 |
| Di-Zeal Limited | Administrative & support | 2025 |
| Diable AUX Cordes Ltd | Manufacturing | 2020 |
| Diablo Technical Services Ltd | Manufacturing | 2025 |
| Diago George PVT Ltd | Wholesale & retail | 2022 |
| Diak Technical Export Ltd | Professional & scientific | 1979 |
| Dial Square Communications Limited | Professional & scientific | 2012 |
| Dialogue Flow Ltd | Information & communication | 2025 |
| Dialysis Healthcare Ltd | Health & social care | 2015 |
| Diamenti Ltd | Arts & recreation | 2024 |
| Diametric Design Limited | Administrative & support | 2003 |
| Diametric Technical Limited | Manufacturing | 1974 |
| Diamond Accounting (Southern) Ltd | Professional & scientific | 2016 |
| Diamond Brickwork & Construction Ltd | Construction | 2023 |
| Diamond Carpentry & Construction UK Limited | Construction | 2016 |
| Diamond Concrete Ltd | Manufacturing | 2023 |
| Diamond Contracts Ltd | Real estate | 2019 |
| Diamond Dips Ltd | Manufacturing | 2020 |
| Diamond Drylining Plastering Limited | Construction | 2008 |
| Diamond Fades Limited | Other services | 2021 |
| Diamond Hvac Ltd | Energy | 2025 |
| Diamond Pizza and Kebab Limited | Hospitality | 2019 |
| Diamond Pizza N Kebab Limited | Hospitality | 2021 |
| Diamond Plumbing & Heating Ltd | Administrative & support | 2008 |
| Diamond Prestige Ltd | Wholesale & retail | 2024 |
| Diamond River Ltd | Manufacturing | 2015 |
| Diamond Sports Performance Ltd | Manufacturing | 2014 |
| Diamond Totton Ltd | Real estate | 2023 |
| Diamond Window Cleaning Hampshire Ltd | Administrative & support | 2026 |
| Diary Quest Ltd | Administrative & support | 2013 |
| Dibden Property Limited | Real estate | 2016 |
| Dibles Park Company Limited | Hospitality | 1995 |
| Dibstuff Ltd | Wholesale & retail | 2020 |