| Digitech TTS Ltd | Information & communication | 2018 |
| Dimity NE Ltd | Arts & recreation | 2025 |
| Direct Tools Supplies Limited | Administrative & support | 2019 |
| Disco Chic Clothing Ltd | Wholesale & retail | 2024 |
| Discount Vapes Limited | Wholesale & retail | 2018 |
| Discountkrafts Limited | Wholesale & retail | 2024 |
| Ditch Please Limited | Administrative & support | 2025 |
| DJB Property Limited | Real estate | 2016 |
| DJK Heating Ltd | Construction | 2021 |
| DJK Plumbing Limited | Construction | 2008 |
| DJL Construction Ltd | Construction | 2025 |
| DJP Accountancy Limited | Professional & scientific | 2011 |
| DKB Inspection Services Ltd | Professional & scientific | 2012 |
| Dlbt Bond Ltd | Hospitality | 2023 |
| Dlighted Limited | Financial services | 2015 |
| DLK Medical Ltd | Health & social care | 2025 |
| DM Property & Electrical Contractors Ltd | Construction | 2026 |
| DME Systems Ltd | Professional & scientific | 2021 |
| DMK Manufacturing Ltd | Manufacturing | 2026 |
| DMR Builders Limited | Construction | 2025 |
| DMW Lifting Services Ltd. | Construction | 2018 |
| DN89SERVICES Limited | Professional & scientific | 2025 |
| Dog Talk Ltd | Wholesale & retail | 2020 |
| DON Vertex Solutions Ltd | Wholesale & retail | 2024 |
| DON8 Ltd | Information & communication | 2020 |
| Donatelloos Ltd | Hospitality | 2023 |
| Dooks Electrical Contractors Ltd | Construction | 2026 |
| Door Twenty One Aesthetics Ltd | Administrative & support | 2017 |
| Double Jump Gaming Ltd. | Wholesale & retail | 2023 |
| DP Coatings Ltd | Construction | 2025 |
| DPC Traffic Management Ltd | Manufacturing | 2019 |
| DR Roofing&Rendering Limited | Construction | 2025 |
| DR69EEM Ltd | Other services | 2023 |
| Drak Barber Ltd | Other services | 2026 |
| Dring Offshore Ltd | Mining & quarrying | 2025 |
| DRX Services Limited | Information & communication | 2025 |
| DRY Lining North East Limited | Construction | 2018 |
| Dryden 1957 Limited | Extraterritorial | 2013 |
| DSL Fire & Security Limited | Administrative & support | 2009 |
| DSM Property Developments Limited | Real estate | 2016 |
| Dtax Limited | Professional & scientific | 2017 |
| DTW Media Consultants Ltd | Professional & scientific | 2022 |
| Dulcetime Ltd | Real estate | 2020 |
| Dunsgreen Court Company Limited | Real estate | 1982 |
| DW Construction North East Building Services Limited | Construction | 2016 |
| DW Flooring Specialists Ltd | Other services | 2022 |
| Dwak Ltd | Hospitality | 2024 |
| Dwne Electrical Limited | Construction | 2016 |
| Dwne Properties Ltd | Real estate | 2025 |
| Dying to Help Community Interest Company | Education | 2023 |
| Dynamic Aikido Nocquet Limited | Arts & recreation | 2003 |
| E Paterson Electrical Services Limited | Construction | 2021 |
| E&I Projects Ltd | Construction | 2018 |
| E&M Empire Limited | Hospitality | 2024 |
| E.H. Wind Limited | Construction | 2023 |
| E.S.Q.B. Ltd | Administrative & support | 2006 |
| East Coast Fibreglass Limited | Extraterritorial | 2017 |
| Eastern Geare Ltd | Information & communication | 2017 |
| Eastmed Aesthetics & Wellness Ltd | Public administration | 2024 |
| Easy Clad UK Limited | Construction | 2018 |
| Easy Sprayers Ltd | Construction | 2025 |
| Ebanks Painting Services Ltd | Administrative & support | 2018 |
| ECF Composites Ltd | Wholesale & retail | 2006 |
| ECN Transport Ltd | Transport & logistics | 2025 |
| Eden Memorials (North East) Limited | Wholesale & retail | 2013 |
| Edgewise Environmental Consultancy Ltd | Professional & scientific | 2025 |
| EDP Properties Ltd | Real estate | 2020 |
| Efficiency Studio Ltd | Administrative & support | 2024 |
| EFM Electrical Solutions Ltd | Other services | 2021 |
| EGJ Holdings Limited | Wholesale & retail | 2026 |
| Eishkin Lodge Management Company Limited | Households | 2007 |
| EKO L'Awa Limited | Wholesale & retail | 2025 |
| EL Dino Ltd | Hospitality | 2024 |
| Elaine Sneddon Beautiful Homes Limited | Hospitality | 2018 |
| Eland Properties Ltd | Real estate | 1995 |
| Eldon Homes Limited | Real estate | 2018 |
| Electronetworks Ltd | Construction | 2019 |
| Elektek Solutions Ltd | Construction | 2024 |
| Elephanta Ltd | Administrative & support | 2025 |
| Elevate Rehabilitation Ltd | Health & social care | 2026 |
| Elexatech Ltd | Construction | 2025 |
| Elextech (Northern) Ltd | Construction | 2019 |
| ELH Engineering Ltd | Professional & scientific | 2019 |
| Elite Branding & Sales Limited | Wholesale & retail | 2017 |
| Elite Equity Investments Ltd | Real estate | 2024 |
| Elite Snag Limited | Construction | 2022 |
| Elle Collective Space Limited | Administrative & support | 2021 |
| Elle Eyto Corporate Trustee Ltd | Extraterritorial | 2025 |
| Elliott Energy Ltd | Construction | 2023 |
| Ellwood Technologies Ltd | Administrative & support | 2019 |
| Elmfield Trading Limited | Other services | 2013 |
| Elsentech Ltd | Information & communication | 2024 |
| EMH Financial Planning Limited | Financial services | 2019 |
| Emilie Robson Writers Ltd | Information & communication | 2023 |
| Emily Carter Aesthetics Ltd | Other services | 2026 |
| Emma Property Developments Limited | Real estate | 2021 |
| Emmaus North East | Hospitality | 2009 |
| Empire Joinery Contractors Ltd | Construction | 2018 |
| Empire Property Empire Investors Ltd | Real estate | 2021 |
| Empowerment Psychological Coaching Ltd | Health & social care | 2023 |