| Energy Events North East Limited | Arts & recreation | 2021 |
| Engaged Bridal Studio Ltd | Wholesale & retail | 2023 |
| Enkora Limited | Information & communication | 2025 |
| Ennovate Ltd | Professional & scientific | 2025 |
| Environmental Electrics Ltd | Manufacturing | 2011 |
| Enviso Global Limited | Professional & scientific | 2014 |
| EPJ Property and Investment Limited | Real estate | 2022 |
| Epoch Enterprises Ltd | Real estate | 2024 |
| EPT Cleaning Ltd | Other services | 2014 |
| Eqyce Limited | Wholesale & retail | 2025 |
| ES Hair & Retail Ltd | Other services | 2026 |
| Escape Intervention Services Ltd. | Health & social care | 2005 |
| Escape Safe (UK) Limited | Manufacturing | 2000 |
| Essential Business Skills North East Limited | Information & communication | 2014 |
| Essential Signs & Graphics Limited | Manufacturing | 2003 |
| Esthetica MRD Limited | Other services | 2023 |
| EVE UK Properties LLP | | 2008 |
| Event Vibes NE Ltd | Arts & recreation | 2023 |
| Event.S.C.S. Limited | Professional & scientific | 2003 |
| Evolution Properties Ltd | Real estate | 2018 |
| Evolve Automations Group Limited | Administrative & support | 2025 |
| Evolve Football Coaching Limited | Arts & recreation | 2025 |
| Evora North East Limited | Real estate | 2022 |
| Excel Plastering & Decorating Limited | Construction | 2025 |
| Experiential (North East) Limited | Health & social care | 2008 |
| EYE2AYE Ltd | Education | 2023 |
| Eyis Resources Limited | Transport & logistics | 2023 |
| F Scott Electrical Ltd | Construction | 2021 |
| Fair Build Ltd | Construction | 2022 |
| Fairlotti Leisure Limited | Hospitality | 2016 |
| Fairway Business International Ltd | Wholesale & retail | 2010 |
| Faith FLY Ltd | Wholesale & retail | 2022 |
| Faith Traders UK Ltd | Transport & logistics | 2020 |
| Fakin IT Tanning Studio Ltd | Other services | 2015 |
| Family Fitness and Food Community Interest Company | Arts & recreation | 2023 |
| FAR North Limited | Information & communication | 2015 |
| Farham and Johnson Construction Services Limited | Construction | 2025 |
| Fashintech Ltd | Professional & scientific | 2026 |
| Fast Food Zone Ltd | Hospitality | 2025 |
| Fast Track Removals and Waste Ltd | Water & waste | 2024 |
| Fawcett Holdings Limited | Hospitality | 2023 |
| FCC Training Ltd | Education | 2024 |
| Federal Signal UK Holdings Limited | Professional & scientific | 1993 |
| Feethams Green (Darlington) Management Company Limited | Households | 2015 |
| Fellgate Developments Ltd | Construction | 2019 |
| Fellshore Ltd | Professional & scientific | 2022 |
| Fellview Limited | Households | 1990 |
| Feltsecure Labs Limited | Information & communication | 2017 |
| Fens Court Management Company Limited | Real estate | 2004 |
| Ferry View Limited | Hospitality | 2024 |
| Fg-Sv Digital Consultancy Services Limited | Information & communication | 2023 |
| Fibra Telecom Ltd | Information & communication | 2019 |
| Fiha & Ayra Ltd | Wholesale & retail | 2014 |
| Filippo Fiore Plumbing Ltd | Construction | 2023 |
| Financial Fitness CIC | Professional & scientific | 2023 |
| Financial Solutions (N.E.) Ltd | Financial services | 2004 |
| Finch Ventures Limited | Financial services | 2020 |
| Finchale View Management Company Limited | Households | 2007 |
| Fiori Marketing Limited | Hospitality | 2017 |
| Fire Elite Training Solutions Ltd | Public administration | 2026 |
| Fire Maintenance Service (UK) Limited | Public administration | 2011 |
| First and Last Health Care Private Ltd | Health & social care | 2021 |
| First Class CUT NE Ltd | Other services | 2025 |
| First Contact Clinical Community Interest Company | Health & social care | 2006 |
| Fish 'N' Chip Fryday Ltd | Hospitality | 2023 |
| Fishermans Catch (South Shields) Limited | Hospitality | 2020 |
| Fit Belli Deli Ltd | Hospitality | 2025 |
| Fitfam Fitness Ltd | Other services | 2017 |
| Fitfam X Realign Health & Wellbeing CIC | Health & social care | 2026 |
| FJB NE Limited | Hospitality | 2025 |
| Fkbr Ltd | Hospitality | 2018 |
| Flanqs Ltd | Mining & quarrying | 2026 |
| Flatliners Limited | Real estate | 2003 |
| Flooring @ Cousins Ltd | Wholesale & retail | 2022 |
| Flow-Contracts Ltd | Professional & scientific | 2026 |
| Flumen Ltd | Real estate | 2023 |
| Focus HSE Ltd | Construction | 2024 |
| Foley Design Limited | Information & communication | 2023 |
| Foley Fitness Club Ltd | Arts & recreation | 2025 |
| Food for Thought Pantry CIC | Hospitality | 2019 |
| Food IS Fuel Ltd | Hospitality | 2019 |
| Food Made Simple Limited | Hospitality | 2022 |
| FOR the Love of BEN Limited | Other services | 1997 |
| Ford Aerospace Limited | Manufacturing | 1944 |
| Ford Engineering Group Limited | Manufacturing | 2008 |
| Forefront Maintenance Limited | Manufacturing | 2026 |
| Forefront Properties Ltd | Real estate | 2020 |
| Forestco Limited | Agriculture & fishing | 2018 |
| Forged 40 Ltd | Information & communication | 2021 |
| Forsa Waste Group Ltd | Hospitality | 2025 |
| Forster-Investments Ltd | Information & communication | 2014 |
| Fort 1961 Limited | Extraterritorial | 2014 |
| Fortress Home Improvements Ltd | Other services | 2018 |
| Fortune Finishing Services Limited | Construction | 2026 |
| Fountain Safety Solutions Limited | Professional & scientific | 2002 |
| Fowler Street Amusements Ltd | Professional & scientific | 2014 |
| FOX and Collier Ltd | Real estate | 2024 |
| Fox’S Repairs Ltd | Manufacturing | 2025 |
| FPJ North East Construction Ltd | Construction | 2025 |
| Frame Structural Consultants Ltd | Professional & scientific | 2026 |