| Coynes Heating & Plumbing Limited | Construction | 2023 |
| CPB Blade & Rope Ltd | Manufacturing | 2023 |
| CPB Shield Surfaces Ltd | Administrative & support | 2025 |
| CPC Electrics NE Ltd | Construction | 2021 |
| CPT Primary Design Limited | Professional & scientific | 2024 |
| CR Safety Solutions Ltd | Construction | 2019 |
| CR Training Services Limited | Education | 2021 |
| Craft and Crumb (NE) Limited | Hospitality | 2026 |
| Craft Creations Paper Ltd | Extraterritorial | 2019 |
| Crafty Cows Wholesale Ltd | Wholesale & retail | 2023 |
| Craig Thwaites Joinery Ltd | Construction | 2025 |
| Craig Todd Brickwork & Developments Ltd | Construction | 2023 |
| Craigmillar Avenue Management Company Limited | Real estate | 2004 |
| Create & Connect Community Interest Company | Arts & recreation | 2025 |
| Creator Guild Ltd | Professional & scientific | 2026 |
| Croft & Moyse Ltd | Construction | 2026 |
| Cross Design Developments Limited | Real estate | 2005 |
| Crossing Paths CIC | Education | 2025 |
| Crown by Lillie Ltd | Other services | 2025 |
| Crown Curry Limited | Hospitality | 2026 |
| CS Supported Employment Limited | Professional & scientific | 2019 |
| CSJ Sushi Ltd | Wholesale & retail | 2024 |
| CSL Technical Services Limited | Other services | 2017 |
| CTP Taxation Services Limited | Professional & scientific | 2009 |
| Ctrl Connect Limited | Information & communication | 2024 |
| Ctrl Technology Solutions Limited | Information & communication | 2019 |
| Ctrl-Networks Limited | Information & communication | 2008 |
| Custom Bags International Limited | Extraterritorial | 2009 |
| Custom Bags Limited | Manufacturing | 2009 |
| Custom Fibre Optics Ltd | Construction | 2022 |
| CW Rope Access Ltd | Professional & scientific | 2016 |
| Cycle Route Limited | Other services | 2009 |
| Cyprus Dreams Limited | Real estate | 2023 |
| D & E Projects Ltd | Construction | 2025 |
| D & G Scott Ltd | Construction | 2010 |
| D & K Plant Hire (North East) Limited | Administrative & support | 2021 |
| D C Tasty Catering Limited | Hospitality | 2013 |
| D E Plumbing Services Limited | Construction | 2007 |
| D J Robinson Engineering Limited | Construction | 2014 |
| D S Private Management Company Ltd | Other services | 2017 |
| D Shaw Glazing Limited | Construction | 2002 |
| D T Construction Group Limited | Construction | 2025 |
| D&D UK Property Ltd | Real estate | 2026 |
| D&H Windows Limited | Construction | 2025 |
| D&S Properties (North East) Ltd | Real estate | 2025 |
| D&S Signature Limited | Wholesale & retail | 2025 |
| D. Joseph PMI Advice Limited | Financial services | 2013 |
| D.E.M Properties Ltd | Real estate | 2021 |
| D.L.Carter and SON Limited | Wholesale & retail | 1959 |
| D.M Offshore Renewables Ltd | Construction | 2025 |
| D.W Taverns Ltd | Hospitality | 2015 |
| DA Coaching Services Ltd | Arts & recreation | 2026 |
| DAA (T/A Sambuca South Shields) Ltd | Hospitality | 2016 |
| Daddy Pizza Limited | Hospitality | 2020 |
| Dainty Dance Ltd | Wholesale & retail | 2019 |
| Daltons Lane Management Company Ltd | Real estate | 2013 |
| Danick Limited | Health & social care | 1997 |
| Daniel Oliver Manning Ltd | Manufacturing | 2019 |
| Danratcliffe Ltd | Manufacturing | 2025 |
| Darren Carr Electrical Ltd | Construction | 2015 |
| Darrenablettaccess Limited | Professional & scientific | 2014 |
| Darvills Removal and Storage Limited | Transport & logistics | 2014 |
| Dasi FRY Ltd | Hospitality | 2023 |
| DATACOLL8 Limited | Information & communication | 2024 |
| Dave Ryla Rigging Ltd | Construction | 2026 |
| David Hall 17 Ltd | Professional & scientific | 2025 |
| Davison Diamond Drilling Ltd | Construction | 2025 |
| DB Show Control & Automation Ltd | Administrative & support | 2012 |
| DBC Logistics Ltd | Transport & logistics | 2026 |
| DC Blade Repair Ltd | Manufacturing | 2022 |
| DCW Offshore Construction Ltd | Construction | 2026 |
| DD Roofing and Building NE Ltd | Construction | 2026 |
| Dead Happy Tattoo Ltd | Other services | 2026 |
| Deadline Environmental Limited | Administrative & support | 2018 |
| Deal Fabrication Ltd | Manufacturing | 2025 |
| Dean House Properties Ltd | Real estate | 2024 |
| Dean Manufacturing Ltd | Manufacturing | 2026 |
| Dean Mcrae Rope Access Ltd | Other services | 2015 |
| Deanroadconveniencestore Ltd | Wholesale & retail | 2025 |
| DEE IT Right Roofing Limited | Construction | 2015 |
| Deepstar Subsea Limited | Manufacturing | 1997 |
| Delhi 6 Express Limited | Hospitality | 2024 |
| Delhi 6 Lounge Westoe Limited | Hospitality | 2023 |
| Delta Heating Solutions NE Ltd | Construction | 2025 |
| Deltasnipe Limited | Administrative & support | 2010 |
| Demir Turkish Salons Ltd | Construction | 2012 |
| Demob JOB Limited | Administrative & support | 2008 |
| Deng Kitchen Limited | Hospitality | 2024 |
| Derma Dolls Training Academy Ltd | Education | 2022 |
| Deshi Kitchen (South Shields) Limited | Hospitality | 2024 |
| Dexters Deli Ltd | Hospitality | 2026 |
| DG HV Jointing Services Ltd | Manufacturing | 2023 |
| DG Impact Media Ltd | Professional & scientific | 2025 |
| DG Properties NE Ltd | Real estate | 2023 |
| Dgdl & Co Ltd | Other services | 2024 |
| DH Offshore Services Limited | Construction | 2017 |
| DHA Electrical Ltd | Professional & scientific | 2021 |
| DHN Decking Ltd | Construction | 2023 |
| Diagnostic and Repairs Ltd | Extraterritorial | 2023 |
| Digiroo Ltd | Professional & scientific | 2024 |