| Sonnymm Limited | Real estate | 2024 |
| Soteria Crown Environment Health and Safety Services Ltd | Professional & scientific | 2026 |
| Soul & Sage Ltd | Health & social care | 2025 |
| Souter Trading International Limited | Wholesale & retail | 1996 |
| South Lucky Limited | Hospitality | 2024 |
| South Quays Block C Management Company Limited | Real estate | 2019 |
| South Quays Management Company Limited | Real estate | 2018 |
| South Shields and Westoe Club Trading Ltd | Other services | 2016 |
| South Shields Cricket Club Trading Limited | Wholesale & retail | 2025 |
| South Shields FC Foundation Limited | Arts & recreation | 2016 |
| South Shields Football Club Group Limited | Financial services | 2019 |
| South Shields Football Club Limited | Construction | 2017 |
| South Shields Golf Club Limited(The) | Other services | 1931 |
| South Shields Golf Club Trading Limited | Arts & recreation | 2016 |
| South Shields Healthcare Ltd | Administrative & support | 2025 |
| South Shields Living Limited | Real estate | 2025 |
| South Shields Marina Ltd | Construction | 2023 |
| South Shields Marine School | Extraterritorial | 2022 |
| South Shields Masonic Hall Limited | Other services | 2025 |
| South Shields Masonic Hall Trading Limited | Other services | 2025 |
| South Shields Properties LLP | | 2023 |
| South Shields Rugby Football Club Ltd | Arts & recreation | 2015 |
| South Shields School of Boxing Community Interest Company | Health & social care | 2024 |
| South Shields Scissors Ltd | Other services | 2026 |
| South Shields Self Storage Ltd | Transport & logistics | 2026 |
| South Shields Visionplus Limited | Wholesale & retail | 1992 |
| South Side Music Tuition Ltd | Education | 2026 |
| South Tyne Building Supplies Limited | Wholesale & retail | 2001 |
| South Tyneside Bathrooms Ltd | Administrative & support | 2017 |
| South Tyneside Building Solutions Ltd | Construction | 2026 |
| South Tyneside Citizens Advice Bureau | Health & social care | 2007 |
| South Tyneside Coachworks Limited | Wholesale & retail | 2026 |
| South Tyneside Construction Ltd | Construction | 2022 |
| South Tyneside Couriers Limited | Transport & logistics | 2017 |
| South Tyneside Electrical Services Limited | Construction | 2026 |
| South Tyneside Gymnastics and Wellbeing Centre Community Interest Company | Administrative & support | 2012 |
| South Tyneside Health Collaboration Ltd | Health & social care | 2017 |
| South Tyneside Homes Limited | Real estate | 2005 |
| South Tyneside Integrated Care Limited | Health & social care | 2014 |
| Southbay Civil Engineering Limited | Construction | 2007 |
| Southbay Civils Limited | Construction | 2001 |
| Southbay Marine Limited | Construction | 2007 |
| Southerton Decorators Ltd | Construction | 2026 |
| Southgarth Management Limited | Households | 1989 |
| Southshields Bargain Ltd | Wholesale & retail | 2026 |
| Southshields Indian Limited | Hospitality | 2019 |
| Sovereign Estate Developments Limited | Construction | 2017 |
| SP Buzz Leisure Limited | Hospitality | 2020 |
| SP Data Services Ltd | Information & communication | 2019 |
| Space Architectural Design Ltd | Professional & scientific | 2025 |
| Spanish Dave Ltd | Manufacturing | 2018 |
| Spartan Joinery Ltd | Construction | 2016 |
| Specialty Services Limited | Manufacturing | 2014 |
| Spenergy Systems Ltd | Professional & scientific | 2023 |
| Spice Station Limited | Hospitality | 2022 |
| Sporting Threads Limited | Information & communication | 2009 |
| Sports Recycler Ltd | Water & waste | 2005 |
| Spud Southshields Limited | Hospitality | 2025 |
| SR Industrial Services Limited | Construction | 2023 |
| SR1 Development Limited | Information & communication | 2011 |
| SR1 Properties Limited | Real estate | 2015 |
| Srivel Ltd | Wholesale & retail | 2026 |
| SRR (London) Trading Limited | Transport & logistics | 2023 |
| SS Food Trade Limited | Hospitality | 2025 |
| Ssfc Stadium Company Limited | Real estate | 2019 |
| SSG North East Limited | Wholesale & retail | 2023 |
| SSP and LA Limited | Real estate | 2018 |
| ST Home Improvements FC Ltd | Construction | 2025 |
| ST John's Court Management (South Shields) Limited | Real estate | 1974 |
| ST Joseph's Holdings Ltd | Information & communication | 2024 |
| ST. Johns Green Management Company Limited | Households | 1985 |
| ST. Thomas Complex Limited | Health & social care | 2014 |
| STACK4HEALTH Ltd | Information & communication | 2026 |
| Stags 1897 Ltd | Hospitality | 2024 |
| Stallion Group North Ltd | Administrative & support | 2024 |
| Stanhope Duck Limited | Hospitality | 2024 |
| Stanton SMC Limited | Real estate | 2024 |
| Stanton Software Solutions Limited | Information & communication | 2016 |
| Stanza NE Ltd | Construction | 2024 |
| Star Nails & Spa Limited | Other services | 2026 |
| Step Forward Care Limited | Health & social care | 2021 |
| Stepform Limited | Construction | 2008 |
| Stephanie Jarvis Podiatry Ltd | Health & social care | 2023 |
| Stephenson Capital Limited | Financial services | 2024 |
| Steven Berry Limited | Education | 2023 |
| Steven Dodd Heating and Plumbing Limited | Construction | 2019 |
| Steven Solves Mortgages Limited | Financial services | 2025 |
| Stevie Tennet Ltd | Arts & recreation | 2021 |
| Stft Holdings Limited | Health & social care | 2014 |
| Stirling Designer Ltd | Wholesale & retail | 2021 |
| Stirling Designer Outlet Ltd | Wholesale & retail | 2022 |
| Stonechester Property Group Ltd | Real estate | 2026 |
| Store 22 Ltd | Wholesale & retail | 2023 |
| STORE24NE Ltd | Other services | 2023 |
| Stracotto Books Ltd | Information & communication | 2018 |
| Strafford Ltd | Manufacturing | 2023 |
| Strapon Watches Ltd | Wholesale & retail | 2020 |
| Strateco Consulting Limited | Information & communication | 2019 |
| Stratgroup Ltd | Manufacturing | 2019 |
| Streamline Property Lettings and Management Ltd | Real estate | 2024 |