| Sean Aggas Ltd | Professional & scientific | 2011 |
| Sean Curtin Legal Services Ltd | Professional & scientific | 2019 |
| Sebi Co 1 Ltd | Manufacturing | 2023 |
| Seca Energy Ltd | Construction | 2025 |
| Security Delivery Transport Limited | Transport & logistics | 2016 |
| Secvuesolutions Ltd | Administrative & support | 2025 |
| Select Living (Eslington Mews) Limited | Hospitality | 2011 |
| Serenity Crystals and Gifts Ltd | Wholesale & retail | 2024 |
| Service From Future Limited | Administrative & support | 2025 |
| Service With a Tile North East Ltd | Other services | 2012 |
| SFI Development Ltd | Construction | 2024 |
| SFM Properties Ltd | Real estate | 2025 |
| SG Housing International Ltd | Construction | 2025 |
| SG Logic UK Ltd | Transport & logistics | 2025 |
| SGL Cleaning Limited | Administrative & support | 2020 |
| Shah Choudhury UK Ltd | Real estate | 2026 |
| Shah Residence Ltd | Real estate | 2026 |
| Shardworks North Ltd | Information & communication | 2025 |
| Shaun Matthias Limited | Construction | 2003 |
| Shaun West Associates Limited | Other services | 2011 |
| Shaun's Conveniences Limited | Wholesale & retail | 2026 |
| Shelby Engineering Ltd | Manufacturing | 2025 |
| Shelmerdine Properties Limited | Financial services | 2025 |
| Shenanigans Bar Ltd | Hospitality | 2026 |
| Shergill Chippy Ltd | Hospitality | 2025 |
| Shergill Fish and Chips Ltd | Hospitality | 2022 |
| Shield Brickwork Limited | Construction | 2003 |
| Shield Inspections and Installations Ltd | Construction | 2014 |
| Shield Paint Inspection Services Limited | Construction | 2024 |
| Shields Barber Ltd | Other services | 2025 |
| Shields Beauty Limited | Other services | 2026 |
| Shields Cabs Ltd | Transport & logistics | 2025 |
| Shields Cars Ltd Ltd | Transport & logistics | 2026 |
| Shields Company Productions Ltd | Information & communication | 2024 |
| Shields Food Services Ltd | Hospitality | 2026 |
| Shields GAS Ltd | Construction | 2020 |
| Shields Group Limited | Hospitality | 2025 |
| Shields Leisure (NE) Limited | Hospitality | 2024 |
| Shields Pizza Ltd | Hospitality | 2019 |
| Shields Property NE Ltd | Real estate | 2024 |
| Shields Property Services Ltd | Real estate | 2024 |
| Shields Shawarma Limited | Hospitality | 2024 |
| Shields Unity CIC | Real estate | 2025 |
| Shieldsya Limited | Wholesale & retail | 2021 |
| Shilds Barber Limited | Other services | 2025 |
| Shine and Smile Services Ltd | Administrative & support | 2026 |
| Shoney (Seonaidh) Wind Limited | Professional & scientific | 2011 |
| Shop Functions Limited | Information & communication | 2024 |
| Shoreline SS Ltd | Hospitality | 2025 |
| Showers Pass UK Limited | Wholesale & retail | 2013 |
| Showrevs Ltd | Wholesale & retail | 2025 |
| Sign IT Hear C.I.C. | Administrative & support | 2012 |
| Signature Brickwork Ltd | Construction | 2023 |
| Signature Housing Limited | Real estate | 2025 |
| Signature One Mortgages Ltd | Financial services | 2025 |
| Silver Springs Properties Ltd | Real estate | 2025 |
| Sima Chippy Ltd | Hospitality | 2026 |
| Simonside Limited | Wholesale & retail | 1991 |
| Simpall Homes Limited | Real estate | 2020 |
| Simpall Property Solutions Limited | Real estate | 2021 |
| Simplehomes Limited | Real estate | 2025 |
| Sincero Business Solutions Ltd | Financial services | 2016 |
| Sinchro Logistics Ltd | Transport & logistics | 2023 |
| Sinia Trocs Ltd | Hospitality | 2026 |
| SIR William FOX Apartments Ltd | Households | 2024 |
| SIT Building Services Ltd | Construction | 2026 |
| SJM Lifting Limited | Administrative & support | 2025 |
| SJP Safety NE Ltd | Wholesale & retail | 2020 |
| SJS Haulage North East Ltd | Transport & logistics | 2016 |
| SK Property Maintenance NE Ltd | Construction | 2025 |
| Skills Line Ltd | Construction | 2025 |
| Skinnergate Limited | Real estate | 2023 |
| Skintech Aesthetics and Medispa Limited | Other services | 2021 |
| Sky Access Worldwide Ltd | Construction | 2025 |
| Skyminedad Limited | Wholesale & retail | 2026 |
| Sleak Clothing Ltd | Wholesale & retail | 2025 |
| SLS PUB Co Limited | Hospitality | 2026 |
| Smart Properties NE Ltd | Real estate | 2025 |
| Smartcore Logistics Ltd | Transport & logistics | 2024 |
| SMB Waste Removals Limited | Water & waste | 2025 |
| SMC Football Coaching Ltd | Education | 2026 |
| SMC PSV Repairs Limited | Wholesale & retail | 2023 |
| SMH Equipment Limited | Manufacturing | 2013 |
| SMH Products Limited | Manufacturing | 1994 |
| SMH Property Holdings Limited | Real estate | 2025 |
| Smith Piping Ltd | Construction | 2025 |
| Smithwrite Publishing Ltd | Wholesale & retail | 2025 |
| Smithy Sales Ltd | Wholesale & retail | 2024 |
| Smoke & Fresh Ltd | Wholesale & retail | 2026 |
| Smoke'D & Smash'D Limited | Hospitality | 2026 |
| Snapshopper Ltd | Wholesale & retail | 2023 |
| Social Media Markateing Ltd | Information & communication | 2024 |
| SOE Electrical Ltd | Other services | 2016 |
| Soef Ltd | Construction | 2022 |
| SOLFAN1 Limited | Arts & recreation | 2015 |
| Somni Holdings Ltd | Real estate | 2024 |
| Somni Stores Ltd | Wholesale & retail | 2024 |
| Sonic Air Systems (Europe) Limited | Manufacturing | 1996 |
| Sonic Minds CIC | Arts & recreation | 2026 |
| Sonny Property Development Limited | Real estate | 2024 |