| RNC Associates Limited | Other services | 2012 |
| Road Race and Customs Limited | Wholesale & retail | 2017 |
| Robert Elsey Conservation Specialist Ltd | Construction | 2013 |
| Robinson Electrical Services Limited | Administrative & support | 2016 |
| Rocah Group Ltd | Real estate | 2021 |
| Rockcliffe Maintenance Limited | Health & social care | 1986 |
| Rocking Horse Cafe Ltd | Hospitality | 2024 |
| Roma Market Ltd | Wholesale & retail | 2026 |
| Rope Access Painting Ltd | Construction | 2023 |
| Rope Access Trade Solution North Ltd | Professional & scientific | 2026 |
| Rope Access Trade Solutions Ltd | Professional & scientific | 2016 |
| Rope Access Trade Solutions NE Ltd | Professional & scientific | 2026 |
| Rope and Rescue Services Ltd | Manufacturing | 2026 |
| Rope Trade Ltd | Construction | 2013 |
| Rose and Crown Holdings Limited | Hospitality | 2025 |
| Roseberry Crescent Limited | Real estate | 2004 |
| Rosetta Gardens (Swarland) Management Company Limited | Households | 2019 |
| Ross Cameron Construction Limited | Construction | 2015 |
| Roup Limited | Real estate | 1987 |
| Royale Electronics Ltd | Wholesale & retail | 2025 |
| Royale Travels Ltd | Wholesale & retail | 2024 |
| RR Retreats Ltd | Real estate | 2025 |
| RRS Retail Limited | Wholesale & retail | 2017 |
| RS Wind Turbine Services Ltd | Professional & scientific | 2018 |
| Rsal Developments Ltd | Construction | 2021 |
| RSM Blinds and Shutter Ltd | Wholesale & retail | 2024 |
| RSR Chartering Limited | Other services | 2020 |
| Rumble Ltd | Real estate | 2026 |
| Rupert Court (Newburn) Management Company Limited | Real estate | 2005 |
| RVM Waste Removal Ltd | Water & waste | 2026 |
| Ryan and Rodin NE Ltd | Hospitality | 2023 |
| Ryanpaintingltd Limited | Construction | 2026 |
| Rymer Solutions Limited | Construction | 2018 |
| S & S Marketing Services Limited | Wholesale & retail | 1998 |
| S Davison (Electrical) Ltd | Construction | 2005 |
| S H Electrical Northern Limited | Construction | 2016 |
| S Marshall Consultancy Ltd | Professional & scientific | 2015 |
| S&B Joinery and Maintenance Ltd | Construction | 2024 |
| S&B Retail and Online Supplies Ltd | Wholesale & retail | 2023 |
| S&Lj. Ltd | Construction | 2012 |
| S&P Construction (N.E) Ltd | Construction | 2018 |
| S&S Cabling Ltd | Wholesale & retail | 2018 |
| S. Cawley Retail Limited | Administrative & support | 2014 |
| S.R.B.W Property Ltd | Construction | 2026 |
| S.Seekers Ltd | Professional & scientific | 2017 |
| S.Singh Medical Services Ltd | Health & social care | 2020 |
| S10 Automotive Ltd | Manufacturing | 2024 |
| Sab's Barber (Northeast) Ltd | Other services | 2026 |
| Safe Access Consultancy Services Ltd | Professional & scientific | 2024 |
| Safework Scaffolding N.E Ltd | Construction | 2022 |
| Safron Rigging Services Ltd | Construction | 2017 |
| SAH Services NE Ltd | Mining & quarrying | 2018 |
| Said Cars Ltd | Wholesale & retail | 2024 |
| Saini Properties Ltd | Real estate | 2021 |
| Sainii Builders Ltd | Construction | 2019 |
| Sainthood Music Limited | Information & communication | 2014 |
| Saltwell Plumbing and Heating Ltd | Construction | 2025 |
| Salty Sea Crew Ltd | Information & communication | 2025 |
| Salty Sea Grips Ltd | Information & communication | 2025 |
| SAM Ward (NE) Ltd | Manufacturing | 2018 |
| Sambuca South Shields Ltd | Hospitality | 2025 |
| Same Electricals Limited | Construction | 2023 |
| Samuel Gibson Consultancy Ltd | Professional & scientific | 2023 |
| Sand Dancer Homes Ltd | Hospitality | 2024 |
| Sandance Creative Limited | Professional & scientific | 2021 |
| Sandancer FM Ltd | Mining & quarrying | 2026 |
| Sanddancer Clothing Ltd | Wholesale & retail | 2020 |
| Sanddancer Properties Ltd | Hospitality | 2026 |
| Sanddancer Retail Limited | Wholesale & retail | 2025 |
| Sandgate Enterprises Limited | Financial services | 2014 |
| Sandhaven Chalets Ltd | Hospitality | 2017 |
| Sandhaven Coastal Village Limited | Hospitality | 2025 |
| Sandhaven Estates Ltd | Real estate | 2024 |
| Sandrpubholdings Ltd | Hospitality | 2024 |
| Sanqin Cuisine Ltd | Hospitality | 2026 |
| Sant Consulting Limited | Professional & scientific | 2024 |
| Sara Carroll Ltd | Hospitality | 2025 |
| Sarah Weafer Ltd | Other services | 2018 |
| Saturn Wholesale Ltd | Wholesale & retail | 2018 |
| Saunders Fibre Ltd | Information & communication | 2025 |
| Sayer Online Sales Ltd | Wholesale & retail | 2023 |
| SB Renewable Maintenance Ltd | Construction | 2019 |
| SB Scaffolding Services Limited | Construction | 2019 |
| SBG SS Ltd | Education | 2022 |
| SC Marketing Media Limited | Administrative & support | 2019 |
| SCD91 Property Management Ltd | Real estate | 2024 |
| SCD91 Services Ltd | Construction | 2023 |
| Scentworks Solutions Limited | Wholesale & retail | 2017 |
| Schofield Electricals Ltd | Manufacturing | 2018 |
| Scholars Gate (Royston) Management Company Limited | Households | 2013 |
| School Inc. Ltd | Professional & scientific | 2020 |
| Scotiapubco Ltd | Hospitality | 2025 |
| Scott & Smith Construction Ltd | Construction | 2019 |
| SD Metalworks Ltd | Manufacturing | 2025 |
| SDS Welding Limited | Administrative & support | 2014 |
| SDT Estates Limited | Real estate | 2021 |
| Se-Shipnav Ltd | Wholesale & retail | 2016 |
| Sea Change South Shields CIC | Hospitality | 2019 |
| Seaham Kindergarten Limited | Education | 2022 |
| Sealane Inshore Limited | Construction | 1993 |