| Quality Glass (D.G.) Limited | Manufacturing | 1998 |
| Quarry Lane Fish & Chips Ltd | Hospitality | 2020 |
| Quayside Buffet Ltd | Hospitality | 2025 |
| Queen ST Fitness Ltd | Arts & recreation | 2018 |
| Queensbury (Newcastle) Limited | Households | 2004 |
| Quick Stop South Shields Ltd | Wholesale & retail | 2026 |
| Quinnergy N E Ltd | Professional & scientific | 2025 |
| R & T Landscapes Limited | Administrative & support | 1996 |
| R H G Ltd | Construction | 2016 |
| R H Stone Surfaces Limited | Manufacturing | 2018 |
| R M Finn Engineering Limited | Professional & scientific | 2016 |
| R Miller Associates Limited | Wholesale & retail | 2003 |
| R Stanley Ltd | Construction | 2013 |
| R Stanley Windows and Doors Ltd | Construction | 2014 |
| R W Philpot Inspection Services Ltd | Other services | 2017 |
| R&B Carpet Fitters Limited | Construction | 2018 |
| R&Eb Ltd | Professional & scientific | 2023 |
| R&H Prestige Investments Ltd | Financial services | 2021 |
| R&R Cleaning Limited | Other services | 2016 |
| R&R Foods and Beverage Ltd | Hospitality | 2024 |
| R&T Estate Ltd | Real estate | 2022 |
| R.Lamb(Jarrow)Limited | Transport & logistics | 1959 |
| R.O.C. PUB Company Limited | Hospitality | 2019 |
| RA Properties NE Ltd | Real estate | 2025 |
| Rabid Graphics Ltd | Professional & scientific | 2019 |
| RAC NE Ltd | Construction | 2024 |
| Rachel Robinson Limited | Information & communication | 2016 |
| Radhekrishna Trading Limited | Wholesale & retail | 2025 |
| Radhuni Restaurant Ltd | Hospitality | 2014 |
| Radio Commz UK Ltd | Wholesale & retail | 2019 |
| RAE Fitness Ltd | Arts & recreation | 2018 |
| Rajco Ltd | Wholesale & retail | 2025 |
| RAM Compliance Limited | Professional & scientific | 2010 |
| Ramsay Telecoms Limited | Construction | 2026 |
| Rapid Solution Technology Ltd | Wholesale & retail | 2020 |
| Rats Group Ltd | Financial services | 2022 |
| RAY Judd Electrical Services Ltd | Manufacturing | 2025 |
| Raydek Window Services Limited | Manufacturing | 2002 |
| Razz Lounge Ltd | Hospitality | 2019 |
| RC Offshore (NE) Ltd | Professional & scientific | 2020 |
| RDT Fabs Ltd | Professional & scientific | 2024 |
| Ready Steady Shoot Photography Ltd | Professional & scientific | 2023 |
| Real (South Tyneside) Limited | Education | 2022 |
| Reav Technical Ltd | Information & communication | 2026 |
| RECOVER3 Ltd | Administrative & support | 2024 |
| Recruiting for Excellence Limited | Education | 2018 |
| Red Amber Archer Limited | Hospitality | 2019 |
| Red Stamp People CIC | Information & communication | 2026 |
| Red Stamp Productions Ltd. | Information & communication | 2020 |
| Redwood Service Station Limited | | 1959 |
| Reeds Sales & Transport Ltd | Wholesale & retail | 2025 |
| Reedsraffles Ltd | Wholesale & retail | 2026 |
| Reface NE Ltd | Wholesale & retail | 2016 |
| Refill Zone North East Ltd | Wholesale & retail | 2023 |
| Regis Cafe Ltd | Hospitality | 2019 |
| Reliability & Integrity Assured Ltd | Manufacturing | 2018 |
| Reliance Financial Management Services Limited | Financial services | 2026 |
| Renewsafe Ltd | Professional & scientific | 2025 |
| Resilience Risk Management Services Ltd | Financial services | 2018 |
| Resourcemene Ltd | Construction | 2025 |
| Response Scaffolding Limited | Construction | 2016 |
| Retainer Pro Ltd | Health & social care | 2024 |
| Revolution Access Ltd | Construction | 2024 |
| RG Hayes Associates Ltd | Professional & scientific | 2022 |
| RGB Rope Access Ltd | Professional & scientific | 2018 |
| RH Stone Fitting Limited | Manufacturing | 2019 |
| Rh-Itservices Ltd | Wholesale & retail | 2021 |
| Richard Dalton Funerals (South Shields) Limited | Other services | 2024 |
| Richard Dalton Funerals Limited | Other services | 2023 |
| Richard Hamblin Limited | Manufacturing | 1960 |
| Riches House Ltd | Professional & scientific | 2024 |
| Richid Limited | Hospitality | 2025 |
| Richmond and Westoe Taxis Limited | Transport & logistics | 2018 |
| Riddell Leisure Limited | Hospitality | 2014 |
| Ridgeway Care Services Ltd | Education | 2014 |
| Rigby Services Limited | Education | 2026 |
| Rigging Hire Services Ltd | Administrative & support | 2025 |
| Rigging Hire Solutions Ltd | Professional & scientific | 2020 |
| Riss FS Ltd | Construction | 2023 |
| Riss Limited | Construction | 2010 |
| Rival Automotive Limited | Wholesale & retail | 2024 |
| River I.T. Solutions Ltd | Information & communication | 2004 |
| River View Cars Limited | Wholesale & retail | 2011 |
| River View Properties NE Ltd | Real estate | 2020 |
| Riverine Systems Ltd | Manufacturing | 2026 |
| Riverroots Whippets Ltd | Agriculture & fishing | 2022 |
| Riverside Asbestos Services Ltd | Water & waste | 2020 |
| Riverside Beach Hotel Ltd | Hospitality | 2023 |
| Riverview (Yarm) Management Company Limited | Real estate | 2006 |
| Riviera Assets Ltd | Real estate | 2026 |
| Rizalina Investments Limited | Real estate | 2022 |
| RJ Access Scaffolding Limited | Construction | 2025 |
| RJ Coates Cosmetics Ltd | Other services | 2021 |
| RJR Industrial Ltd | Construction | 2019 |
| Rkcs Consulting Ltd | Administrative & support | 2024 |
| RL Cabling Limited | Manufacturing | 2025 |
| RLT Tech Limited | Construction | 2023 |
| RLU Offshore Ltd | Construction | 2025 |
| RMF Electrical Ltd | Professional & scientific | 2024 |
| RMW Fletcher Properties Limited | Real estate | 2026 |