| Strong at Heart Community Interest Company | Health & social care | 2025 |
| Stryde Coaching Ltd | Professional & scientific | 2026 |
| Studio Yours Limited | Administrative & support | 2024 |
| Sultan Creations Ltd | Wholesale & retail | 2025 |
| Summit Electrical Limited | Professional & scientific | 2024 |
| Sunderland Integrated Care Limited | Health & social care | 2014 |
| Sunderland Live Ltd | Professional & scientific | 2024 |
| Sunny South Limited | Hospitality | 2023 |
| Sunnyside Recruitment Ltd | Administrative & support | 2016 |
| Sunset Orange Limited | Manufacturing | 2022 |
| Sunshine Blinds NE Ltd | Other services | 2025 |
| Sunshine Nursery Boldon CIC | Education | 2026 |
| Super Tech South Shields Ltd | Wholesale & retail | 2018 |
| Supercharged Performance NE Ltd | Arts & recreation | 2023 |
| Surfdek Limited | Manufacturing | 2021 |
| Surt (NE) CIC | Health & social care | 2020 |
| Susan Bell Hairdressing Services Limited | Other services | 2008 |
| Susan Spokes Real Estate Ltd | Real estate | 2022 |
| Sustainable South Tyneside (Hebburn) Limited | Energy | 2020 |
| Sustainable South Tyneside (Jarrow) Limited | Energy | 2020 |
| Sutha Ltd | Wholesale & retail | 2022 |
| Sutherland Tyres Ltd | Wholesale & retail | 2022 |
| Sutton 98 Limited | Construction | 2025 |
| Sutton Hall Bar Trading Company Limited | Other services | 2016 |
| SW MOY Limited | Professional & scientific | 2019 |
| SW Power Management Limited | Professional & scientific | 2023 |
| SW PUB Enterprises Limited | Hospitality | 2019 |
| Swallow Vale Properties Ltd | Real estate | 2026 |
| Swan Instrument Services Limited | Administrative & support | 2007 |
| Swan Instrumentation Limited | Professional & scientific | 2024 |
| Swift Search Recruitmemt Ltd | Professional & scientific | 2024 |
| Swift TAN Limited | Wholesale & retail | 2023 |
| Swift Water Solutions Limited | Transport & logistics | 2017 |
| Swiftlink Support Services Ltd | Administrative & support | 2026 |
| Swimfun North East Ltd | Education | 2023 |
| Switch and Save Utilities Limited | Energy | 2024 |
| Switch for Savings Ltd | Professional & scientific | 2019 |
| Switch NOW International Ltd | Energy | 2017 |
| Swmc Social Top Club Limited | Hospitality | 2024 |
| SYL Eats Ltd | Hospitality | 2025 |
| Synch Freight Services Limited | Wholesale & retail | 2012 |
| Syntopia Ltd | Information & communication | 2016 |
| T & a Safety Services Limited | Professional & scientific | 2019 |
| T & D Project Services Limited | Professional & scientific | 2016 |
| T & S Barbers Ltd | Other services | 2019 |
| T J Real Estate Development Limited | Real estate | 2023 |
| T K W 88 Ltd | Hospitality | 2016 |
| T&D Logistic Ltd | Transport & logistics | 2017 |
| T&T Roofing (N.E.) Limited | Construction | 2017 |
| T.A.G Inspection Services Limited | Manufacturing | 2015 |
| T.A.S. Project Solutions Limited | Professional & scientific | 2018 |
| TA Radio Communications Ltd | Information & communication | 2025 |
| TAJ Curry Centre Ltd | Hospitality | 2019 |
| Talisyn Limited | Information & communication | 2011 |
| Talk of the Tyne Properties Ltd | Real estate | 2022 |
| Talk Renewables Limited | Construction | 2024 |
| Tanderon Limited | Real estate | 2004 |
| Tandoori Catering Ltd | Hospitality | 2017 |
| Tann Engineering Management Limited | Professional & scientific | 2024 |
| Tann Estates Limited | Real estate | 2025 |
| Target Auto Limited | Education | 2019 |
| Taskit Consultancy (UK) Limited | Professional & scientific | 2007 |
| Taste of Ocean Ltd | Hospitality | 2025 |
| Tastelicious Ltd | Hospitality | 2023 |
| TAU Media Group Ltd | Professional & scientific | 2026 |
| Taurus ENG Properties Ltd | Real estate | 2025 |
| Taurus ENG. Group Limited | Professional & scientific | 2019 |
| Taurus ENG. Ltd | Administrative & support | 2018 |
| TAV Safety Services Ltd | Professional & scientific | 2024 |
| Tax Networks Limited | Financial services | 2009 |
| Taylor Properties (North East) Limited | Real estate | 2025 |
| Taylor Property and Investments Ltd | Real estate | 2025 |
| Tayplan Limited | Professional & scientific | 2020 |
| TCT NE Ltd | Wholesale & retail | 2025 |
| TD Scaffolding NE Ltd | Construction | 2024 |
| Tdaly Painting Limited | Construction | 2025 |
| Teamstar's Entertainment Ltd | Information & communication | 2023 |
| Tech Sphere Solutions Store Ltd | Wholesale & retail | 2026 |
| Techability (North East) Limited | Information & communication | 2020 |
| Tecnicom Engineering Services Ltd. | Professional & scientific | 1998 |
| Tedco Business Support Limited | Administrative & support | 2013 |
| Tedwell Services Ltd | Professional & scientific | 2022 |
| Tee&Dee Passion Ltd | Other services | 2016 |
| Tempest Subsea Ltd | Manufacturing | 2022 |
| Temple Coatings Ltd | Manufacturing | 2015 |
| Templeman Services Ltd | Transport & logistics | 2019 |
| Templetown Canopies Ltd | Manufacturing | 2012 |
| Tenablefix Ltd | Construction | 2021 |
| Tfmentor Ltd | Extraterritorial | 2024 |
| Tfnails Ltd | Other services | 2025 |
| TGS Industrial Supplies Limited | Wholesale & retail | 2002 |
| Thai Orchid (NE) Ltd | Hospitality | 2010 |
| That Nail GUY Ltd | Education | 2020 |
| THE Address (NE) Ltd | Wholesale & retail | 2014 |
| THE Art Stall Limited | Wholesale & retail | 2020 |
| THE Ashley NE Ltd | Hospitality | 2018 |
| THE Baking Boutique Ltd | Manufacturing | 2026 |
| THE Batter Frydays Ltd | Hospitality | 2025 |
| THE Bede Co-Operative Trust | Administrative & support | 2010 |
| THE Black & Gold Drinks Company Ltd | Wholesale & retail | 2024 |