| S4 IT Consulting Services Ltd | Information & communication | 2019 |
| SA Project Delivery Services Ltd | Information & communication | 2026 |
| SA Removals Ltd | Transport & logistics | 2023 |
| SA Sutton Diagnostics Limited | Health & social care | 2020 |
| Sa&Co Limited | Professional & scientific | 2008 |
| SAA Properties (Midlands) Limited | Real estate | 2025 |
| Saaaf Medical Services Limited | Health & social care | 2013 |
| Saab Investments Ltd | Real estate | 2018 |
| Saamir Properties Ltd | Real estate | 2025 |
| SAB Innovation Limited | Professional & scientific | 2014 |
| Saba Property Homes Ltd | Real estate | 2026 |
| Sabby Investments Limited | Real estate | 2020 |
| Sabr Enterprise Ltd | Manufacturing | 2020 |
| Sabre Landscaping Limited | Administrative & support | 2018 |
| Sabreline Consultants Limited | Professional & scientific | 2002 |
| Sabreline Property Development Limited | Real estate | 2023 |
| Sabrina Brown Consulting Limited | Professional & scientific | 2014 |
| SABT1 Limited | Administrative & support | 2009 |
| Sach Investments Ltd | Real estate | 2025 |
| Sach Properties Limited | Households | 2025 |
| Sachle Consultants Limited | Professional & scientific | 2020 |
| Sacred Tours Midlands Ltd | Administrative & support | 2018 |
| Sacs Sales and Marketing Limited | Wholesale & retail | 2024 |
| Sadlers Meadow Management Company Limited | Administrative & support | 2000 |
| Saeed Audiology Ltd | Health & social care | 2024 |
| SAF Directions Limited | Information & communication | 2018 |
| Safedoors Limited | Extraterritorial | 2019 |
| Safehaven Supported Living Limited | Health & social care | 2025 |
| Safer Homes Consultancy Ltd | Professional & scientific | 2025 |
| Safer Recruit Limited | Information & communication | 2024 |
| Safety and Security Barrier Holdings Limited | Manufacturing | 2015 |
| Safety NET Medics Limited | Health & social care | 2021 |
| Saffar Ltd | Information & communication | 2025 |
| SAI RAM Services Ltd | Professional & scientific | 2023 |
| SAI Shreehan Limited | Health & social care | 2020 |
| Saicho Ltd. | Manufacturing | 2017 |
| Sail and Paddle Holdings Limited | Financial services | 2025 |
| Saini Holdings Limited | Financial services | 2022 |
| Saint Aidan's Limited | Real estate | 2025 |
| Saiya & Mahi Investments Limited | Real estate | 2024 |
| SAJ Property UK Limited | Real estate | 2021 |
| Sajik Computer Services Limited | Information & communication | 1987 |
| Sajtechs Limited | Manufacturing | 2017 |
| Sakina Community Housing Ltd | Real estate | 2025 |
| Salartis Solutions Limited | Professional & scientific | 2021 |
| Salcombe Dental Practice Limited | Real estate | 2006 |
| Sali Optics Ltd | Health & social care | 2021 |
| Sally Anderson Limited | Administrative & support | 2011 |
| Sally Leese Associates Limited | Professional & scientific | 2016 |
| Sally Supplements Limited | Health & social care | 2024 |
| Salon 5 Limited | Other services | 2020 |
| Salon NO. 100 Ltd | Other services | 2023 |
| Salter Cleaning Services Limited | Administrative & support | 2003 |
| Salterns Limited | Real estate | 2008 |
| Salterns Maintenance Limited | Extraterritorial | 2009 |
| Salveo Coaching Limited | Other services | 2017 |
| SAM Edwards Residences Ltd | Real estate | 2026 |
| SAM Pharma Ltd | Health & social care | 2025 |
| SAM Prop Co Holding Ltd | Real estate | 2022 |
| SAM Technology Services Limited | Information & communication | 2016 |
| Sam/Isa Holdco Ltd | Real estate | 2023 |
| Sama Capital Holdings Ltd | Real estate | 2024 |
| Sama Capital Ltd | Real estate | 2022 |
| Sama Hospitality Ltd | Hospitality | 2024 |
| Sama Investment Group Ltd | Professional & scientific | 2025 |
| Sama Opco Ltd | Real estate | 2026 |
| Sama Platform 1 Ltd | Real estate | 2020 |
| Sama Real Estate Ltd | Professional & scientific | 2019 |
| Sama Social Property Ventures Ltd | Construction | 2024 |
| Sama Sram Holdco Ltd | Professional & scientific | 2024 |
| Sama Ventures 2 Ltd | Financial services | 2023 |
| Sama Ventures 3 Ltd | Real estate | 2024 |
| Sama Ventures Ltd | Construction | 2020 |
| Samaira Enterprise Limited | Real estate | 2020 |
| Samantha Hession Ltd | Other services | 2021 |
| Samasta Limited | Professional & scientific | 2018 |
| Samay Work Cafe Ltd | Hospitality | 2025 |
| Sambrook Finance Limited | Financial services | 2024 |
| Sameh Botros Limited | Real estate | 2016 |
| Samina Bibi Limited | Professional & scientific | 2021 |
| Samk Ltd | Wholesale & retail | 2023 |
| Samman Investments Limited | Real estate | 2025 |
| Samrex Curtains Limited | Manufacturing | 2022 |
| Samrex Holdings Limited | Financial services | 2022 |
| Samrex Investments Limited | Real estate | 2022 |
| Samwantsyourcar Ltd | Wholesale & retail | 2025 |
| Samwon Ltd | Transport & logistics | 2019 |
| SAN & SAN Ltd | Real estate | 2020 |
| SAN Financial Services Limited | Information & communication | 2015 |
| SAN Shirley Ltd | Wholesale & retail | 2023 |
| Sanan Group Ltd | Real estate | 2018 |
| Sanbrook Equestrian Ltd | Agriculture & fishing | 2016 |
| Sanbrook Group Ltd | Financial services | 2024 |
| Sandaala Ltd | Wholesale & retail | 2020 |
| Sandaco Ltd | Professional & scientific | 2014 |
| Sanderlings Accountancy Services Limited | Professional & scientific | 2015 |
| Sanderlings Insolvency Services Limited | Professional & scientific | 2016 |
| Sanderlings Limited Liability Partnership | | 2002 |
| Sandher Investments Limited | Real estate | 2022 |
| Sandhu Advisory Ltd | Information & communication | 2026 |