| Sands Wealth Management Limited | Administrative & support | 2009 |
| Sanghera Property Group Limited | Real estate | 2025 |
| Sanj Medical Limited | Health & social care | 2015 |
| SANJBUSINESS21 Ltd | Transport & logistics | 2025 |
| Sanjit Developments Ltd | Construction | 2000 |
| Sannox Partnership Limited | Professional & scientific | 2011 |
| Sansai Consultancy Limited | Professional & scientific | 2021 |
| Santa's Fields Ltd | Agriculture & fishing | 2021 |
| Santillo Collective Limited | Professional & scientific | 2026 |
| Santillo Consulting Limited | Administrative & support | 2012 |
| Santon Asset Management Ltd | Real estate | 2017 |
| Santon Services Ltd | Transport & logistics | 2023 |
| Santoro Milan MCR Ltd | Wholesale & retail | 2022 |
| Sanvi IT Ltd | Information & communication | 2012 |
| Saoirse Cinaed Limited | Professional & scientific | 2010 |
| Saoirse Midlands Ltd. | Education | 2025 |
| Sapper Sweeps Chimney Services Ltd | Administrative & support | 2025 |
| Saptech Solutions Ltd | Information & communication | 2011 |
| Sapui Solutions Limited | Information & communication | 2014 |
| Sara's Services Ltd | Wholesale & retail | 2015 |
| Sarah Hughes HR Ltd | Professional & scientific | 2022 |
| Sarah Kealy Management Services Limited | Administrative & support | 2012 |
| Sarathi Consulting Services Ltd | Information & communication | 2021 |
| Sarbel UK Holding Company | Professional & scientific | 2017 |
| Sardians Business Solutions Limited | Information & communication | 2012 |
| Sardians Holdings Ltd | Administrative & support | 2019 |
| Sardians Property Investments Ltd | Real estate | 2019 |
| Sarek Limited | Real estate | 2022 |
| Saroya's of B93 Ltd | Wholesale & retail | 2021 |
| SAS Property Capital Ltd | Real estate | 2026 |
| SAS Technology Limited | Information & communication | 2016 |
| Sataki UK Ltd | Wholesale & retail | 2021 |
| Sate Properties Limited | Real estate | 2025 |
| Satnam Building Consultancy Limited | Construction | 2020 |
| Satuma Investments Ltd | Real estate | 2014 |
| Sausage Face Limited | Real estate | 2024 |
| Savannah Property Management Ltd | Real estate | 2019 |
| Savoca Capital Limited | Real estate | 2026 |
| Savva Family Dental Care Ltd | Health & social care | 2019 |
| SAW Accounting & Tax Advisory Limited | Professional & scientific | 2008 |
| SAW RE 26 Ltd | Real estate | 2019 |
| Saxon Fasteners Limited | | 1980 |
| Says Investments Limited | Real estate | 2021 |
| Saysell Foods Limited | Hospitality | 2024 |
| SAZ Professional Services Ltd | Professional & scientific | 2021 |
| SB Electrical Contractors Midlands Ltd | Construction | 2025 |
| SB Global Logistics Limited | Transport & logistics | 2024 |
| SB Hire Limited | Construction | 2015 |
| SB Home Improvements Ltd | Construction | 2006 |
| SB Project Controls Limited | Professional & scientific | 2015 |
| SBA Care Ltd | Health & social care | 2025 |
| SBO Developments Limited | Construction | 2020 |
| SBS (Cumbria) Limited | Extraterritorial | 2021 |
| SBT Commercials Ltd | Extraterritorial | 2011 |
| SBT Logistics Limited | Extraterritorial | 2014 |
| SC Histo DX Ltd | Health & social care | 2026 |
| SC Narrowboats Limited | Manufacturing | 2025 |
| SC Pharma Consulting Limited | Health & social care | 2021 |
| SC Prop 1 Ltd | Health & social care | 2024 |
| SC Prop 2 Ltd | Health & social care | 2024 |
| SC Prop 3 Ltd | Health & social care | 2025 |
| Scai Investments Limited | Financial services | 2022 |
| Scalene Clothing Ltd | Wholesale & retail | 2025 |
| Scaleport Limited | Agriculture & fishing | 1978 |
| Scaleup Coach Limited | Professional & scientific | 2022 |
| Scaleup Dynamics Ltd | Professional & scientific | 2020 |
| Scalloir Ltd | Health & social care | 2020 |
| Scalvex Limited | Other services | 2026 |
| Scammell and Nyland Limited | Information & communication | 2020 |
| Scan Dental Laboratory Ltd | Manufacturing | 2024 |
| Scanlon Building Ltd | Manufacturing | 2022 |
| SCD Energy Consulting Ltd | Professional & scientific | 2014 |
| Sceptre Estates Ltd | Construction | 2017 |
| SCH Solihull Brickwork Ltd | Construction | 2019 |
| Scheme Hub Limited | Extraterritorial | 2001 |
| Schnicks Limited | Extraterritorial | 1981 |
| Scholars Court Management (Solihull) Limited | Real estate | 2012 |
| Schoolweave Ltd | Education | 2020 |
| SCJ Capital Limited | Real estate | 2012 |
| SCM Management Ltd | Professional & scientific | 2019 |
| Scoff West Midlands Limited | Hospitality | 2025 |
| Scolly Limited | Transport & logistics | 2016 |
| Scoobysnax Ltd | Hospitality | 2016 |
| Scoops N Bites Limited | Hospitality | 2025 |
| Scope Sister Ltd | Health & social care | 2026 |
| Scorpion Industries Limited | Information & communication | 2021 |
| Scotplas Trade Centres Limited | Extraterritorial | 2024 |
| Scott Sheldon UK Limited | Professional & scientific | 2024 |
| Scott Wright Properties Ltd | Real estate | 2020 |
| Scotts Props Ltd | Real estate | 2025 |
| Scqc Limited | Professional & scientific | 2001 |
| Scry Development Limited | Information & communication | 2007 |
| SCT Aesthetics Ltd | Education | 2022 |
| Scuba for ALL Ltd | Extraterritorial | 2010 |
| Scuba Industries Trade Association Limited | Arts & recreation | 1994 |
| Scubl Storage Solutions Limited | Wholesale & retail | 2023 |
| Sculptures Hairdressing Ltd | Other services | 2011 |
| SD Appliance Repairs Ltd | Other services | 2023 |
| Sdcj Limited | Financial services | 2026 |
| SDK Technology Ltd | Information & communication | 2019 |