| RUI Health Sports Ltd | Health & social care | 2022 |
| Rukhsar Ltd | Health & social care | 2023 |
| Rumana Property Group Ltd | Real estate | 2025 |
| Runjing Century Holding Limited | Wholesale & retail | 2022 |
| Rupert Davies Catering Limited | Hospitality | 2023 |
| Rushford Blue Consulting Limited | Information & communication | 2013 |
| Russ Fryer Limited | Wholesale & retail | 2006 |
| Russel-Young Consultancy Limited | Health & social care | 2023 |
| Russell & Co Interiors Ltd | Wholesale & retail | 2026 |
| Russell Adams Limited | Information & communication | 1987 |
| Russell Heritage Golf Ltd | Arts & recreation | 2019 |
| Rustic Roast Kitchen Ltd | Hospitality | 2022 |
| Rustyz Food Ltd | Hospitality | 2021 |
| Ruth Deehan Consulting Ltd | Professional & scientific | 2012 |
| Ruvaa Cleaning Services Ltd | Administrative & support | 2026 |
| RV Business Solutions Limited | Professional & scientific | 2012 |
| RVH Safety Management Ltd | Administrative & support | 2023 |
| Rvvm Property Ltd | Real estate | 2022 |
| RW Construction (Midlands) Limited | Construction | 2022 |
| RW Dorridge Limited | Hospitality | 2025 |
| RW Investments (Midlands) Limited | Real estate | 2024 |
| Rwab UK (Ramgarhia Welfare Association Birmingham) Limited | Other services | 2020 |
| RWG Building Services Ltd | Construction | 2025 |
| RWW Property Services Ltd | Real estate | 2019 |
| RX AI Healthcare Ltd | Information & communication | 2025 |
| RX AI Holdings Ltd | Financial services | 2025 |
| Ryality Bytes Ltd | Information & communication | 2003 |
| Ryan Drew Engineering Ltd | Construction | 2021 |
| Ryan Weston Enterprises Ltd | Information & communication | 2022 |
| Ryan's Removals and Storage Ltd | Transport & logistics | 2011 |
| RYAN007 Limited | Hospitality | 2018 |
| Ryans Removals Limited | Transport & logistics | 2001 |
| RYK Consultants Ltd | Construction | 2017 |
| Rymac Metals Limited | Construction | 2001 |
| Rymax Carpentry & Building Ltd | Construction | 2025 |
| Ryotek FSC Limited | Other services | 2012 |
| Rytax Consultants Limited | Professional & scientific | 2009 |
| Ryzon Automotive Limited | Wholesale & retail | 2021 |
| RZJ Ltd | Health & social care | 2021 |
| RZR Logistics Ltd | Transport & logistics | 2026 |
| S & J Oral Health Care Ltd | Health & social care | 2018 |
| S & L Building Group Limited | Construction | 2020 |
| S & N Commercial Limited | Real estate | 2014 |
| S & N Resources Ltd | Other services | 2020 |
| S & R Khan Limited | Wholesale & retail | 2024 |
| S & S Leicester Limited | Hospitality | 2019 |
| S & U PLC | Financial services | 1938 |
| S & U Stores Limited | Extraterritorial | 1948 |
| S a Major Carpentry Limited | Construction | 2016 |
| S a Plasterers LLP | | 2016 |
| S and S Health Ltd | Health & social care | 2024 |
| S B Homes & Properties Limited | Real estate | 2018 |
| S B Taylor and Co Ltd | Health & social care | 2020 |
| S C a Developments Limited | Construction | 2016 |
| S D Martin Ltd | Real estate | 2020 |
| S J Delaney Scaffolding Limited | Construction | 2015 |
| S J L Plant Installations Ltd | Construction | 2026 |
| S K Allen Ltd | Construction | 2026 |
| S K MAF Ltd | Real estate | 2017 |
| S Khan Properties Limited | Real estate | 2024 |
| S L Holdings Limited | Extraterritorial | 2007 |
| S LAD Consultancy Ltd | Real estate | 2020 |
| S Mottram Properties Ltd | Real estate | 2019 |
| S Panchal Ltd | Administrative & support | 2026 |
| S Parsons Hair Limited | Other services | 2017 |
| S R Properties Midlands Ltd | Real estate | 2025 |
| S S C Surgical Ltd | Health & social care | 2015 |
| S S K Courier Services Limited | Transport & logistics | 2002 |
| S S S Optometric Services Limited | Health & social care | 2002 |
| S Wakefield Cars Limited | Wholesale & retail | 2013 |
| S&C Medical Limited | Health & social care | 2026 |
| S&H Cafe Catering Ltd | Hospitality | 2024 |
| S&H Carpentry & Joinery Ltd | Manufacturing | 2026 |
| S&H COX Farms Limited | Agriculture & fishing | 2022 |
| S&I Collections Ltd | Wholesale & retail | 2020 |
| S&I Shop Ltd | Hospitality | 2024 |
| S&K Properties Solihull Limited | Real estate | 2024 |
| S&L Developments NW Ltd | Construction | 2024 |
| S&L Lettings NW Ltd | Real estate | 2024 |
| S&S Roofing WM Ltd | Construction | 2020 |
| S&S Tech Solutions Ltd | Professional & scientific | 2023 |
| S&Z Property Holdings Ltd | Real estate | 2023 |
| S. Bogue Bathrooms Limited | Construction | 2003 |
| S. D. Hinley Limited | Extraterritorial | 1993 |
| S. Donovan Commercial Services Ltd | Professional & scientific | 2025 |
| S. K. Fallon Decorating Limited | Construction | 2004 |
| S. Kitaure Construction Limited | Construction | 2000 |
| S.A Medical Consultancy Ltd | Health & social care | 2025 |
| S.A. Electrical (West Midlands) Ltd | Other services | 2017 |
| S.A. Moughal Limited | Manufacturing | 1986 |
| S.A.M. Photography Limited | Professional & scientific | 2005 |
| S.D.G.P. Locum Limited | Health & social care | 2014 |
| S.J Parker Services Limited | Wholesale & retail | 2025 |
| S.K Elevations Ltd | Other services | 2023 |
| S.O.S. Builders Limited | Extraterritorial | 2007 |
| S.R. Gregory (Plumbing & Heating) Limited | Construction | 1998 |
| S1NCLAIR Holdings Ltd | Wholesale & retail | 2021 |
| S2C Franchising Limited | Administrative & support | 2017 |
| S2C Midlands Limited | Administrative & support | 2015 |
| S4 1M Limited | Other services | 2019 |