| Simply Transport Mids Ltd | Transport & logistics | 2018 |
| Sincere Care Services Limited | Public administration | 2018 |
| Sinextra Limited | Wholesale & retail | 2014 |
| Singh Buildings Ltd | Real estate | 2023 |
| Singhsaab Investment Ltd | Real estate | 2025 |
| Site Contracts Ltd | Construction | 2016 |
| Site Electrical Refurbishment Services Ltd. | Manufacturing | 2012 |
| Site Risk Ltd | Information & communication | 2024 |
| Siwus Company Ltd | Manufacturing | 2018 |
| Sixseeds Investments Limited | Real estate | 2026 |
| Sixty SIX Storage Ltd | Administrative & support | 2025 |
| SJ Eagle Ltd | Construction | 2025 |
| SJ Marketing and Advertising Ltd | Professional & scientific | 2025 |
| SJB Superclean Ltd | Water & waste | 2026 |
| SJB Transport Solutions Ltd | Transport & logistics | 2023 |
| SJH Commercial Limited | Real estate | 2024 |
| SJS Bhullar Ltd | Manufacturing | 2025 |
| SJZ Consultancy Limited | Professional & scientific | 2025 |
| SK Car Company Ltd | Wholesale & retail | 2023 |
| SK Couriers WM Ltd | Transport & logistics | 2025 |
| SK Enterprises Birmingham Ltd | Wholesale & retail | 2024 |
| SK Express Connivance Ltd | Wholesale & retail | 2026 |
| SK Grill House Limited | Hospitality | 2025 |
| SK Maintenance Ltd | Construction | 2025 |
| SK Motor Repairs Ltd | Wholesale & retail | 2020 |
| SK Property GRP Ltd | Real estate | 2026 |
| SKF Inspire Ltd | Real estate | 2023 |
| Skilly London Academy Ltd | Education | 2025 |
| Skin & Laser Aesthetics Limited | Other services | 2024 |
| Skin and Sound CIC | Health & social care | 2025 |
| Skin Medica Clinic Ltd | Health & social care | 2025 |
| Skk(Uk) Ltd | Wholesale & retail | 2020 |
| SKS Distribution Ltd | Wholesale & retail | 2024 |
| Sky Vestige Ltd | Wholesale & retail | 2022 |
| Sky WAS Limited | Energy | 2019 |
| Skyami Management Ltd | Professional & scientific | 2022 |
| Skyamiagency Ltd | Professional & scientific | 2025 |
| Skylark Digital Ltd | Construction | 2020 |
| Skylark Software Ltd | Construction | 2020 |
| Skylink Elite Ltd | Transport & logistics | 2024 |
| SL Properties WM Ltd | Real estate | 2024 |
| SLC Community | Hospitality | 2025 |
| Slgh 1 Ltd | Real estate | 2025 |
| Slicker Pharma Limited | Other services | 2022 |
| Slowmo Productions Ltd | Information & communication | 2021 |
| SLP Consultancy Limited | Administrative & support | 2014 |
| Slupianek Limited | Administrative & support | 2026 |
| Small Farmers Coffee Ltd | Manufacturing | 2018 |
| Smart Body Repairs Ltd | Wholesale & retail | 2024 |
| Smart Labour Construction Ltd | Administrative & support | 2020 |
| Smart Packoging Ltd | Administrative & support | 2026 |
| Smart Servings Cuisine Ltd | Manufacturing | 2024 |
| Smart Think Property Ltd | Real estate | 2026 |
| Smartnovation Ltd | Information & communication | 2020 |
| Smarty Pants @ Lightwoods House Ltd | Education | 2017 |
| Smethwick Asra Limited | Health & social care | 1987 |
| Smethwick Barbers Ltd | Other services | 2026 |
| Smethwick Car Parts Ltd | Administrative & support | 2014 |
| Smethwick Carpet Furniture Ware House Ltd | Wholesale & retail | 2019 |
| Smethwick Engines Limited | Manufacturing | 2016 |
| Smethwick Halal Meat Ltd | Wholesale & retail | 2024 |
| Smethwick Health and Wellbeing Education Trust | Education | 2009 |
| Smethwick Mobiles Ltd | Other services | 2016 |
| Smethwick Pakistani Muslims Association Ltd | Administrative & support | 2004 |
| Smethwick Pet Shop Ltd | Wholesale & retail | 2022 |
| Smethwick Pizza Ltd | Hospitality | 2026 |
| Smethwick Properties Ltd | Real estate | 2026 |
| Smethwick Red COW Ltd | Hospitality | 2016 |
| Smethwick Supermarket Ltd | Wholesale & retail | 2025 |
| SMG M&E Services Ltd | Construction | 2019 |
| SMH Immigration Services Ltd | Administrative & support | 2024 |
| Smiledeed Ltd | Wholesale & retail | 2025 |
| Smiley Foods Limited | Hospitality | 2024 |
| SMK Kebabs Ltd | Hospitality | 2026 |
| SMK Red COW Ltd | Hospitality | 2025 |
| SMQ Properties (Midlands) Ltd | Real estate | 2017 |
| SMS Properties (WM) Ltd | Real estate | 2024 |
| SN Business Ltd | Wholesale & retail | 2021 |
| Snapgear Ltd | Professional & scientific | 2025 |
| Snar Limited | Wholesale & retail | 2026 |
| Snatex Limited | Construction | 2022 |
| SNOOPY21 Limited | Wholesale & retail | 2019 |
| Snow 6 Bees Limited | Health & social care | 2024 |
| SNS Accountancy Ltd | Professional & scientific | 2010 |
| SNS Vision Ltd | Health & social care | 2025 |
| SNV and S Transport Ltd | Transport & logistics | 2026 |
| SO Elle Limited | Wholesale & retail | 2025 |
| SO Good Studio Ltd | Professional & scientific | 2018 |
| Soccer Sports Limited | Manufacturing | 1997 |
| Social Muscle Ltd | Professional & scientific | 2022 |
| Sock Game Ltd | Wholesale & retail | 2024 |
| SOH Property Ltd | Real estate | 2021 |
| Soho Bollywood Styles Ltd | Other services | 2024 |
| Soho Cash & Carry Limited | Wholesale & retail | 2000 |
| Solara Homes Ltd | Manufacturing | 2024 |
| Sole Circle UK CIC | Arts & recreation | 2021 |
| Solid Edge Rendering Ltd | Construction | 2026 |
| Soltana Ltd | Wholesale & retail | 2026 |
| Solution 4 Caterer Ltd | Wholesale & retail | 2024 |
| Soma: Sensory Oriented Media & Arts Ltd | Arts & recreation | 2025 |