| SAT Tera Ltd | Information & communication | 2019 |
| Satara Property Ltd | Construction | 2024 |
| Satgun Randhawa Ltd | Transport & logistics | 2024 |
| Satnam Singh SAM Builder Ltd | Construction | 2019 |
| Satyam Shiv Limited | Wholesale & retail | 2012 |
| Saviton Works Limited | Construction | 2024 |
| Savvy Impact Limited | Wholesale & retail | 2024 |
| Sawo Limited | Health & social care | 2014 |
| SB Connections Limited | Construction | 2025 |
| SB Endeavors Ltd | Real estate | 2024 |
| SB Iphone & Smart Phone Limited | Wholesale & retail | 2025 |
| SB Manufacturing (UK) Limited | Wholesale & retail | 2010 |
| SBF 2022 Limited | Wholesale & retail | 2022 |
| Scaffolding U.K. Ltd | Construction | 2021 |
| Scalure Hospitality Consultants Ltd | Information & communication | 2025 |
| Scenic Eclipse Properties Ltd | Real estate | 2020 |
| Scent Vape Ltd | Wholesale & retail | 2025 |
| Scheff Foods Limited | Manufacturing | 1986 |
| Scheff Holdings Limited | Manufacturing | 2024 |
| Scocs Limited | Professional & scientific | 2018 |
| Scorpio Smethwick Services Limited | Manufacturing | 2013 |
| Scout Trading Ltd | Education | 2026 |
| SCS WM Ltd | Wholesale & retail | 2025 |
| Scylla Computers Ltd | Construction | 2020 |
| SD Catering Birmingham Ltd | Hospitality | 2024 |
| SD Foster Upholsterer Ltd | Other services | 2017 |
| SD Home Crafters Limited | Construction | 2025 |
| SD Trans Logistics Limited | Transport & logistics | 2020 |
| SDM Builder U.K. Ltd | Construction | 2024 |
| Seal Xpress Limited | Wholesale & retail | 2009 |
| Seamore Properties Limited | Professional & scientific | 2002 |
| Search Consulting Limited | Information & communication | 2021 |
| Sebastian&Insulation Construction Ltd | Construction | 2024 |
| Sections & Profiles Limited | Extraterritorial | 1977 |
| Securcity Limited | Construction | 2012 |
| Secure Construction Ltd | Construction | 2023 |
| Secure Destruction Services Limited | Extraterritorial | 2020 |
| Securemind Tech Ltd | Information & communication | 2026 |
| Securenext Technologies Ltd | Information & communication | 2020 |
| Securus Investments Limited | Administrative & support | 2021 |
| Seligal Ltd | Transport & logistics | 2023 |
| Sellify Ventures Ltd | Wholesale & retail | 2025 |
| Serpentine Corporation Ltd | Information & communication | 2022 |
| Seth Drylining Ltd | Construction | 2023 |
| Sets Food Ltd | Hospitality | 2017 |
| Seva Grace Home Care Ltd | Health & social care | 2026 |
| Seven Hills Properties Holdings Limited | Financial services | 2025 |
| Sf&Autos Limited | Wholesale & retail | 2019 |
| SFC Birmingham Limited | Hospitality | 2018 |
| SG2 Investments Ltd | Real estate | 2020 |
| Sgen Infotech Limited | Information & communication | 2011 |
| Sgen Properties Limited | Real estate | 2017 |
| SGS Properties WM Ltd | Real estate | 2023 |
| Sgtdeo Transport Company Ltd | Transport & logistics | 2024 |
| SHA Joinery & Interiors Ltd | Manufacturing | 2025 |
| Shabanakhalid Limited | Wholesale & retail | 2021 |
| Shada Travel and Tour Ltd | Administrative & support | 2026 |
| Shada Unisex Hair Studio Ltd | Other services | 2025 |
| Shadashiv Ltd | Wholesale & retail | 2019 |
| Shady Grove (Alsager) Ltd | Wholesale & retail | 2018 |
| Shady Grove News Ltd | Wholesale & retail | 2025 |
| Shah PVT Limited | Hospitality | 2025 |
| Shahid Jewellers Ltd | Wholesale & retail | 2023 |
| Shaki Developers Ltd | Construction | 2026 |
| Shakko's Ltd | Wholesale & retail | 2021 |
| Shaloom Homz Ltd | Real estate | 2022 |
| Shamraj Restaurant Limited | Hospitality | 2003 |
| Shandar Windows Ltd | Construction | 2021 |
| Sharing Stories CIC | Arts & recreation | 2024 |
| Sharol H. Samms Ltd | Transport & logistics | 2020 |
| Sharons Couture Ltd | Manufacturing | 2012 |
| Shawarma AL Chef Smethwick Ltd | Transport & logistics | 2023 |
| Shelby GRP Ltd | Construction | 2020 |
| Shelter Solutions Limited | Real estate | 2019 |
| Sher Khan Builders Ltd | Construction | 2020 |
| Sher Storage Ltd | Transport & logistics | 2016 |
| Shimla Cocktails Ltd | Hospitality | 2023 |
| Shiny Barbers Ltd | Other services | 2026 |
| Shipwise Limited | Wholesale & retail | 2024 |
| Shireland Collegiate Academy Trust | Education | 2007 |
| Shiv SAI (UK) Ltd | Wholesale & retail | 2014 |
| Shivaay Global Foods Ltd | Wholesale & retail | 2026 |
| Shivn Record Deliveries Ltd | Transport & logistics | 2021 |
| Shonazz Eduverse Ltd. | Information & communication | 2023 |
| Shopitude Ltd | Wholesale & retail | 2025 |
| Shpet Tiku Ltd | Transport & logistics | 2025 |
| Shrewsbury Restaurant Ltd | Hospitality | 2018 |
| Shri Bala JII Transport Limited | Transport & logistics | 2023 |
| Shunshui Ltd | Health & social care | 2019 |
| Shutter Door Repair and Maintenance Limited | Construction | 1937 |
| Sians Corner Limited | Hospitality | 2019 |
| Sibinet Limited | Administrative & support | 2023 |
| Sicilian Fish Bar Ltd | Hospitality | 2019 |
| Sidhu Investment Group Limited | Real estate | 2025 |
| Sidhu Properties WM Ltd | Real estate | 2025 |
| Sidna Autos Ltd | Wholesale & retail | 2026 |
| Sietiezi Ltd | Wholesale & retail | 2025 |
| Sikhs for Labour Limited | Administrative & support | 2022 |
| Silla Computers Ltd | Construction | 2020 |
| Simongolf Ltd. | Wholesale & retail | 2021 |