| SBH 1B Limited | Hospitality | 2019 |
| SBS62 Limited | Manufacturing | 2017 |
| SC Refrigeration Ltd | Agriculture & fishing | 2021 |
| Scale Estate Management Co Limited | Real estate | 2000 |
| Scalegill Apartments Limited | Households | 2000 |
| Scalegill Estate Limited | Administrative & support | 2000 |
| Scargill House Ltd | Extraterritorial | 2011 |
| Scargill Movement | Hospitality | 2008 |
| Scarwood Limited | Households | 2021 |
| Scented Creations Ltd | Wholesale & retail | 2020 |
| Sea Light Development Ltd | Professional & scientific | 2019 |
| Seaside Golf Tours Ltd | Administrative & support | 2018 |
| Secret Service Limited | Information & communication | 2020 |
| Sedgwick Services Ltd | Construction | 2011 |
| Selby Surveying Limited | Construction | 2007 |
| Select Components Limited | Wholesale & retail | 1997 |
| Select Football Ltd | Arts & recreation | 2023 |
| Select Kitchens (Skipton) Limited | Wholesale & retail | 2025 |
| Selestial Limited | Information & communication | 2002 |
| Sell My Touring Caravans Limited | Wholesale & retail | 2026 |
| Selsdon Associates Limited | Financial services | 1984 |
| Send Contract Cars Limited | Transport & logistics | 2024 |
| Sento Martial Arts Limited | Arts & recreation | 2011 |
| Serene Aura Limited | Wholesale & retail | 2025 |
| SES (Skipton) Limited | Construction | 2007 |
| Settle Land Surveys Limited | Construction | 2007 |
| Settle Orchestra Productions Ltd | Arts & recreation | 2026 |
| Seven Days Vitamin Company Limited | Manufacturing | 2017 |
| SEW Properties Limited | Real estate | 2013 |
| SG BSM Ltd | Construction | 2022 |
| Shackleton Plumbing Ltd | Construction | 2015 |
| Shackleton Properties Ltd | Real estate | 2024 |
| Shamikhan Holdings Limited | Real estate | 2018 |
| Shamshir Mini Market Ltd | Wholesale & retail | 2026 |
| Shaygate Farm Camping Ltd | Hospitality | 2025 |
| SHC Group Holdings Limited | Financial services | 2022 |
| SHC Group Investments Limited | Information & communication | 2022 |
| Shcw 1 Ltd | Administrative & support | 2024 |
| Sheena Limited | Information & communication | 2005 |
| Sheeptown Brewery Limited | Manufacturing | 2017 |
| Sheeptown Consulting Limited | Professional & scientific | 2026 |
| Shelldanco Ltd | Hospitality | 2022 |
| Shepherd & Walker Limited | Real estate | 1955 |
| Shepherd Partnership (Holdings) Limited | Financial services | 2018 |
| Shepherd Partnership Group Limited | Financial services | 2025 |
| Shepherd Partnership Limited | Professional & scientific | 2006 |
| Shine & Sparkle Cleaners Limited | Administrative & support | 2021 |
| Shooligans Shoes Limited | Wholesale & retail | 2011 |
| Shotwick Park Estate Limited | Professional & scientific | 2022 |
| Shul Co 006 Limited | Administrative & support | 2016 |
| SIG Birmingham Limited | Financial services | 2024 |
| Sigma Synergy Ltd | Wholesale & retail | 2024 |
| Sijomon Limited | Information & communication | 2004 |
| Silver Cross Nurseries Limited | Professional & scientific | 2009 |
| Silver FOX Properties (Yorkshire) Ltd | Households | 2026 |
| Simedics Ltd | Information & communication | 2008 |
| Simmlong Ltd | Hospitality | 2025 |
| Simon Roberts Property Limited | Real estate | 2022 |
| Simon Woodyatt Properties Limited | Real estate | 2008 |
| Simple System (Yorkshire Dales) Limited | Hospitality | 2010 |
| Siraxis Ltd | Information & communication | 2020 |
| SK (UK) Limited | Administrative & support | 2002 |
| SK Eight Dental & Cosmetic Centre Ltd | Health & social care | 2020 |
| Skin Deep Treatments (Yorkshire) Limited | Other services | 2017 |
| Skin Sculpt by DR Clarke Limited | Health & social care | 2025 |
| Skip to School Ltd | Wholesale & retail | 2017 |
| Skipton & Craven Taxis Ltd | Transport & logistics | 2024 |
| Skipton Airport Transfers Ltd | Transport & logistics | 2025 |
| Skipton Balti Spice Ltd | Hospitality | 2024 |
| Skipton BID Limited | Other services | 2008 |
| Skipton Boat Trips Limited | Transport & logistics | 2018 |
| Skipton Body Repair Centre Ltd. | Manufacturing | 2001 |
| Skipton Camerata Limited | Arts & recreation | 2009 |
| Skipton Camper Hire Ltd | Administrative & support | 2024 |
| Skipton Castle Limited | Arts & recreation | 1967 |
| Skipton Covered Bonds Limited Liability Partnership | | 2008 |
| Skipton Developments Limited | Construction | 2023 |
| Skipton Domestics Limited | Manufacturing | 2022 |
| Skipton Engineered Solutions Limited | Professional & scientific | 2018 |
| Skipton Golf Club Catering Limited | Arts & recreation | 2016 |
| Skipton Health & Fitness Limited | Arts & recreation | 2022 |
| Skipton Hire Centre Limited | Administrative & support | 1973 |
| Skipton Holiday Homes Limited | Hospitality | 2020 |
| Skipton House Management Company Limited | Hospitality | 2008 |
| Skipton Hub Limited | Wholesale & retail | 2025 |
| Skipton IT Services Limited | Information & communication | 2012 |
| Skipton Joinery Ltd | Manufacturing | 2019 |
| Skipton Joinery Properties Limited | Real estate | 2021 |
| Skipton Kitchen Limited | Hospitality | 2026 |
| Skipton Moor Consulting Limited | Information & communication | 2014 |
| Skipton Nails Ltd | Other services | 2025 |
| Skipton Opticians Ltd | Health & social care | 2023 |
| Skipton Scaffolds Ltd | Construction | 2013 |
| Skipton Self Drive Limited | Administrative & support | 1994 |
| Skipton Self Store Limited | Administrative & support | 2018 |
| Skipton Sheet Metal Co Limited | Manufacturing | 2009 |
| Skipton Sports Hub Limited | Arts & recreation | 2023 |
| Skipton Stationery & Office Equipment Limited | Wholesale & retail | 2007 |
| Skipton Stone Building and Groundworks Ltd | Construction | 2023 |
| Skipton Subway Fresh Food Ltd | Wholesale & retail | 2015 |