| Skipton Tech Limited | Information & communication | 2024 |
| Skipton Tennis Centre Limited | Arts & recreation | 2018 |
| Skipton Tyres 24/7 Ltd | Wholesale & retail | 2025 |
| Skipton Vintage Supply Limited | Wholesale & retail | 2026 |
| Skipton Wholesale Limited | Wholesale & retail | 2020 |
| Skipton Woods Limited | Extraterritorial | 1965 |
| Skipton's NO 1 Store Ltd | Wholesale & retail | 2024 |
| Skirfare Barn Ltd | Hospitality | 2018 |
| Skyraikes Limited | Professional & scientific | 2019 |
| Slow Art Company Limited | Extraterritorial | 2008 |
| Smales&Co Properties Limited | Construction | 2026 |
| Smart Capital Finance Limited | Financial services | 2025 |
| Smart Coach Ltd | Professional & scientific | 2025 |
| Smart Gallery Ltd | Wholesale & retail | 2019 |
| SMG Financial & Business Management Services Ltd | Administrative & support | 2001 |
| Snape Munroe Limited | Professional & scientific | 2004 |
| Snaygill Property Limited | Real estate | 2013 |
| Snowdrops Consulting Limited | Professional & scientific | 2023 |
| Soccer Hub Academy LLP | | 2025 |
| Solaire Tanning Co Limited | Other services | 2024 |
| Solidus Crumlin Limited | Administrative & support | 1999 |
| Solidus Packaging Solutions Limited | Manufacturing | 1998 |
| Solidus UK Solutions Ltd | Manufacturing | 2015 |
| Sorella Skipton Ltd | Hospitality | 2025 |
| Sound Bar (Skipton) Limited | Hospitality | 2017 |
| Source Control Ltd | Real estate | 2014 |
| SP Bricklayers Limited | Construction | 2015 |
| Spa Town Construction Limited | Construction | 2023 |
| Space Architecture & Design Limited | Professional & scientific | 2003 |
| Space Partnerships Limited | Professional & scientific | 2010 |
| Space Partnerships Properties Limited | Real estate | 2019 |
| Spark Executive Coaching Ltd. | Professional & scientific | 2009 |
| Sparks Careers Ltd | Professional & scientific | 2012 |
| Sparrow Networks Limited | Information & communication | 2015 |
| Spayce Limited | Professional & scientific | 2001 |
| Special Home Care Ltd | Health & social care | 2024 |
| Speed 12 Garage Limited | Wholesale & retail | 2022 |
| Spellow's of Yorkshire Limited | Transport & logistics | 2016 |
| Spencer Goldsmith Ltd | Financial services | 2022 |
| Spencer Services (Skipton) Limited | Construction | 2002 |
| Sphere Associates Limited | Professional & scientific | 2012 |
| Splash Property Management Ltd | Real estate | 2017 |
| Splash Sounds Ltd | Wholesale & retail | 2015 |
| Splash Systems Limited | Administrative & support | 2007 |
| Sport First Agency Limited | Arts & recreation | 2008 |
| Spray and Protect Ltd | Construction | 2019 |
| Springbank Care Home (Silsden) Limited | Health & social care | 2015 |
| Springtime Investors Limited | Financial services | 2024 |
| SPS Roofing Contractors Limited | Construction | 2020 |
| SQB Consultants Limited | Professional & scientific | 2011 |
| Squarerose Limited | Extraterritorial | 1977 |
| SRB Reclamations Limited | Construction | 2001 |
| SSJ Performance Cars Limited | Wholesale & retail | 2025 |
| ST Helen's Properties Limited | Real estate | 2021 |
| ST. Andrews Management Limited | Households | 1982 |
| St.Michael's Mews (Leeds) Management Company Limited | Households | 1986 |
| Stable Smart Limited | Wholesale & retail | 2025 |
| Stag Civils Yorkshire Ltd | Construction | 2021 |
| Stage Hire ( North West ) Ltd | Arts & recreation | 2024 |
| Staincliffe LLP | | 2009 |
| Stainton Cotes Limited | Real estate | 2021 |
| Stanhope Gardens Limited | Real estate | 1985 |
| Stanhope Hotels Limited | Extraterritorial | 1985 |
| Stanhope Stud Limited | Professional & scientific | 1994 |
| Station Yard Joinery Limited | Other services | 2014 |
| Steadman Construction Limited | Construction | 2010 |
| Steeton Court Limited | Health & social care | 1989 |
| Step-Hop Ltd | Hospitality | 2025 |
| Stephen Platt Consulting Ltd | Administrative & support | 2017 |
| Sterling Tax Solutions Ltd | Financial services | 2010 |
| Steve Law Estate Planning Ltd | Other services | 2026 |
| Stevens Wealth Management Ltd | Administrative & support | 2017 |
| Stewart Brown Consulting Limited | Professional & scientific | 2015 |
| Stirton Properties Limited | Real estate | 2020 |
| Stitch Express Skipton Ltd | Other services | 2025 |
| Stock Green Farm Ltd | Agriculture & fishing | 2022 |
| Stockcheck Limited | Administrative & support | 1983 |
| Stocktake Solutions Ltd | Information & communication | 1997 |
| Stocktake UK Ltd | Administrative & support | 1995 |
| Stone Head Projects Ltd | Construction | 2025 |
| Stonelands Estates Limited | Professional & scientific | 2020 |
| Stoneridge Consulting Limited | Administrative & support | 2025 |
| Stoutduck Limited | Manufacturing | 2020 |
| Stow Solutions Ltd | Professional & scientific | 2012 |
| Strandholmeweston | Administrative & support | 2011 |
| Stroli Limited | Wholesale & retail | 2021 |
| Strongvalue Limited | Transport & logistics | 1996 |
| Stuart Shuttleworth Decorators Limited | Construction | 2003 |
| Stubbing Hill Developments Ltd | Construction | 2018 |
| Subcp Contractors Ltd | Professional & scientific | 2022 |
| Sun Station Ltd | Administrative & support | 2014 |
| Sunningdale Court Residents Management Company Limited | Households | 2023 |
| Supergolfer Accessories Ltd | Wholesale & retail | 2022 |
| Sustainable Rooftops Ltd | Construction | 2022 |
| Sutcliffe Construction Holdings Limited | Real estate | 2010 |
| Sutcliffe Construction Limited | Construction | 1998 |
| SUTHOLD1 Limited | Financial services | 2024 |
| SUTHOLD2 Limited | Financial services | 2024 |
| Sutplant Holdings Limited | Real estate | 2001 |
| Sutplant Limited | Administrative & support | 1998 |