| Straight Lines ARE Fine Limited | Arts & recreation | 2014 |
| Strand Properties (UK) Limited | Real estate | 2007 |
| Strange Consulting Services Limited | Information & communication | 2014 |
| Strangely Logical Ltd | Information & communication | 2026 |
| Strasse Gym Limited | Administrative & support | 2020 |
| Strata Property Management Ltd | Construction | 2026 |
| Stratalabs Ltd | Manufacturing | 2023 |
| Strategic & Operational Estates Ltd | Water & waste | 2014 |
| Strategic Centric Care Ltd | Health & social care | 2019 |
| Strategic Cloud Solutions Ltd | Information & communication | 2018 |
| Strategic Corporate Finance Group Limited | Financial services | 2021 |
| Strategic Engineering Services Ltd | Manufacturing | 2024 |
| Strategic Software Solutions Ltd | Information & communication | 2019 |
| Strategy Games Limited | Manufacturing | 2007 |
| Stratford PUB Company Ltd | Hospitality | 2019 |
| Stratigraphy Ground Engineers Ltd | Construction | 2019 |
| Stratton Recruitment Solutions Ltd | Administrative & support | 2022 |
| Stratun Limited | Professional & scientific | 2026 |
| Stratus Care Group Ltd | Health & social care | 2023 |
| Stratus Labs Limited | Manufacturing | 2019 |
| Strawberry LEE Limited | Financial services | 2018 |
| Strawberry Noodle Limited | Professional & scientific | 2026 |
| Strawberry Racing Limited | Wholesale & retail | 2002 |
| Strawberry Student Homes Limited | Real estate | 2016 |
| Stray Holdings Limited | Professional & scientific | 2024 |
| Stream Acquisitions Limited | Information & communication | 2014 |
| Stream Midco Limited | Information & communication | 2014 |
| Stream Topco Limited | Information & communication | 2014 |
| STREAM05 Group Limited | Other services | 2022 |
| STREAM7 Limited | Information & communication | 2013 |
| Streamism Ltd | Information & communication | 2018 |
| Strebor Music Limited | Arts & recreation | 2022 |
| Street Art Kitchen Ltd | Hospitality | 2018 |
| Street Crane Services Limited | Professional & scientific | 2000 |
| Street Cranexpress Holdings Limited | Professional & scientific | 2016 |
| Street Cranexpress Limited | Manufacturing | 2010 |
| Street Express Limited | Professional & scientific | 2000 |
| Street Kitchen Services Limited | Hospitality | 2021 |
| Streetfood Events Ltd | Hospitality | 2024 |
| Streets in the Sky Limited | Hospitality | 2015 |
| Streetview Limited | Real estate | 2002 |
| Streetwise Lettings Limited | Real estate | 2015 |
| Streety ENT Ltd | Professional & scientific | 2019 |
| Strengh & Honour Independent Traders Ltd | Hospitality | 2025 |
| Strength Systems Ltd | Arts & recreation | 2025 |
| Strengths at Work Ltd | Professional & scientific | 2022 |
| Stria Limited | Information & communication | 2004 |
| Strictly Structural Engineering Ltd | Construction | 2013 |
| Strictly Vape Limited | Wholesale & retail | 2024 |
| Strida (UK) Ltd | Construction | 2014 |
| Strideout Runners C.I.C. | Education | 2024 |
| String Agency Limited | Professional & scientific | 2016 |
| Stringer Bramall Properties Ltd | Real estate | 2014 |
| Stripey Design Ltd | Information & communication | 2009 |
| Strives Sporting Events Ltd | Arts & recreation | 2025 |
| Strivis Facilities Ltd | Administrative & support | 2026 |
| Stroke Research and Community Support | Wholesale & retail | 2012 |
| Strolling Mammal Limited | Arts & recreation | 2026 |
| Strong Aerial Fitness Ltd | Arts & recreation | 2022 |
| Strong Student Lets Limited | Households | 2018 |
| Strong Women Collective Ltd | Education | 2023 |
| Strong Women Consultancy Ltd | Professional & scientific | 2024 |
| Strontium Management Limited | Financial services | 2012 |
| Stroud Building Services Ltd | Construction | 2020 |
| Stroud Regeneration Limited | Construction | 2018 |
| Strozpy Limited | Wholesale & retail | 2015 |
| Structural Interiors Limited | Construction | 1992 |
| Structure Sport and Fitness Ltd. | Arts & recreation | 2013 |
| Structure Store Limited | Construction | 2025 |
| Structureclad (UK) Ltd | Construction | 2014 |
| Strutt Chiropractic Ltd | Health & social care | 2011 |
| Strutterworth Management Solutions Ltd | Real estate | 2025 |
| Strynemoor Limited | Construction | 2005 |
| STS Distributors Limited | Hospitality | 2000 |
| Stuart Developments Ltd | Construction | 2014 |
| Stuart Hamilton Plant Limited | Administrative & support | 1977 |
| Stuart Harrod Financial Services Limited | Financial services | 2011 |
| Stuart ROY Clarke Ltd | Information & communication | 2018 |
| Stuart Sandford Enterprises Limited | Arts & recreation | 2010 |
| Stuart Watson Decorating Ltd | Construction | 2015 |
| Stuart Wilson Haulage Ltd | Transport & logistics | 1962 |
| Student Trading Limited | Other services | 2021 |
| Studfield Properties Ltd | Real estate | 2025 |
| Studi-O Edwards Limited | Professional & scientific | 2023 |
| Studio 1 @ the Akademy Ltd | Administrative & support | 2023 |
| Studio 912 Limited | Real estate | 2015 |
| Studio Alda Ltd | Professional & scientific | 2025 |
| Studio Arends Ltd | Professional & scientific | 2024 |
| Studio Budgie Galore Limited | Manufacturing | 2015 |
| Studio Chad Ltd | Professional & scientific | 2025 |
| Studio Chisholm Ltd | Professional & scientific | 2020 |
| Studio Citizen Limited | Information & communication | 2022 |
| Studio Cloud Ltd | Professional & scientific | 2021 |
| Studio D Investment Limited | Other services | 2010 |
| Studio Design and Print Limited | Manufacturing | 2009 |
| Studio Egan Ltd | Professional & scientific | 2025 |
| Studio Fonder Ltd | Professional & scientific | 2024 |
| Studio Greenstone Ltd | Professional & scientific | 2019 |
| Studio Hair Chairs Ltd | Other services | 2025 |
| Studio IF Ltd | Professional & scientific | 2024 |