| Spatha Properties Limited | Construction | 2006 |
| SPB Consultancy Ltd | Professional & scientific | 2018 |
| Spcmc Limited | Real estate | 2016 |
| SPD Holdings Limited | Professional & scientific | 2004 |
| SPD Property Services Ltd | Real estate | 2024 |
| Speaker Finder Ltd | Other services | 2023 |
| Speanbridge Medical Limited | Health & social care | 2018 |
| Spear & Jackson (Tools) Limited | Extraterritorial | 1997 |
| Spear & Jackson Group Limited | Financial services | 2012 |
| Spear & Jackson Holdings Limited | Financial services | 1905 |
| Spear & Jackson Industrial Saws Limited | Extraterritorial | 1997 |
| Spear & Jackson Limited | Financial services | 1989 |
| Spear & Jackson UK Limited | Manufacturing | 1967 |
| Spear Studios Limited | Wholesale & retail | 2025 |
| Spear Technology Holdings Limited | Financial services | 2024 |
| Spear Tools Limited | Extraterritorial | 1997 |
| Spearwell Tools Limited | Extraterritorial | 1997 |
| Spearwood Holdings Ltd | Manufacturing | 2020 |
| Spec Network Limited | Real estate | 2022 |
| Special Diet Store Limited | Wholesale & retail | 2012 |
| Special Melted Products Limited | Manufacturing | 1985 |
| Special Property Developments Limited | Real estate | 2021 |
| Specialised Fixings Limited | Extraterritorial | 2003 |
| Specialised Movers Limited | Transport & logistics | 2008 |
| Specialised Movers Trustees Limited | Financial services | 2022 |
| Specialised Rail Contractors Limited | Construction | 2009 |
| Specialised Tools & Equipment Limited | Manufacturing | 2007 |
| Specialist Beauty Designs Ltd | Other services | 2017 |
| Specialist Enforcement Services Limited | Other services | 2020 |
| Specialist Engineering (Yorkshire) Limited | Manufacturing | 2023 |
| Specialist Fixings and Construction Products Limited | Extraterritorial | 1995 |
| Specialist Paediatrics Ltd | Health & social care | 2025 |
| Specialist Projects Limited | Professional & scientific | 2025 |
| Specialist Solutions Ltd | Professional & scientific | 2022 |
| Specialist Tiling Contractors Limited | Construction | 2011 |
| Speciality Steel UK Limited | Manufacturing | 2016 |
| Specourt Limited | Hospitality | 1973 |
| Spectacle Accountancy Ltd | Professional & scientific | 2025 |
| Spectra Health Ltd | Health & social care | 2024 |
| Spectra IT Solutions Ltd | Information & communication | 2026 |
| Spectrum Active Limited | Professional & scientific | 2010 |
| Spectrum Active NOT for Profit Ltd. | Education | 2011 |
| Spectrum Finance Limited | Financial services | 2020 |
| Spectrum Insurance Services Limited | Financial services | 2004 |
| Spectrum Social Care Ltd | Professional & scientific | 2000 |
| Spectrum Touring LLP | | 2009 |
| Spectrum Worldwide Ltd | Wholesale & retail | 2018 |
| Spectrum X Limited | Construction | 2024 |
| Speed Motor Service Ltd | Wholesale & retail | 2023 |
| Speed Service Repair Centre Limited | Wholesale & retail | 2025 |
| Speedair Logistics Ltd | Transport & logistics | 2024 |
| Speedboxuk Limited | Transport & logistics | 2023 |
| Speedicut Saws Limited | Extraterritorial | 1997 |
| Speedy Fitness Limited | Arts & recreation | 2022 |
| Speight Properties Limited | Real estate | 2018 |
| Speldhurst Reiki Limited | Administrative & support | 2020 |
| Spen Property Ltd | Real estate | 2026 |
| Spence's Landscapes Limited | Administrative & support | 2018 |
| Spencer Brother Developments Limited | Real estate | 2023 |
| Spencer Property Limited | Real estate | 2011 |
| Spencer Technologies UK Limited | Information & communication | 2014 |
| Spencer With Hall Limited | Other services | 1998 |
| Spencers Agents Limited | Real estate | 2011 |
| Spencers Consultants Limited | Real estate | 2016 |
| Spencers Point Holdings Ltd | Real estate | 2022 |
| Spencers Trust Limited | Professional & scientific | 2024 |
| Spengler Group Ltd | Wholesale & retail | 2023 |
| Spennco Limited | Information & communication | 2025 |
| Spent LED Ltd | Real estate | 2021 |
| Spero Solutions Ltd | Professional & scientific | 2018 |
| SPG Access Limited | Professional & scientific | 2014 |
| Spica Property Investments Ltd | Real estate | 2026 |
| Spice Club Takeaway Limited | Hospitality | 2019 |
| Spice Corner Renishaw Ltd | Hospitality | 2022 |
| Spice Forum Ltd | Hospitality | 2019 |
| Spiceham Ltd | Real estate | 2022 |
| Spicer Hill Wind Farm Limited | Energy | 2011 |
| Spicer Manor Limited | Hospitality | 2018 |
| Spick and Span Cleaning Ltd | Administrative & support | 2025 |
| Spicor Ltd | Health & social care | 2019 |
| Spicy Flavours Ltd | Hospitality | 2017 |
| Spiers & Boden Limited | Arts & recreation | 2022 |
| Spike Electrical Limited | Construction | 2023 |
| Spike Productions Limited | Information & communication | 2016 |
| Spikeisland Limited | Professional & scientific | 2025 |
| Spikey Profile Limited | Professional & scientific | 2009 |
| Spill-It Ltd | Professional & scientific | 2025 |
| Spink Design Limited | Professional & scientific | 2013 |
| Spinkhall Developments Ltd | Construction | 2017 |
| Spinkhill Consulting Services Limited | Administrative & support | 2024 |
| Spinkhill Investments Limited | Administrative & support | 2005 |
| Spinning Discs Limited | Wholesale & retail | 2016 |
| Spinshaw Contract Solutions Limited | Construction | 2019 |
| Spiralux Engineering Limited | Extraterritorial | 1997 |
| Spiralux Tools Limited | Extraterritorial | 1997 |
| Spire Business Solutions Ltd | Administrative & support | 2023 |
| Spire Care Services Ltd | Administrative & support | 2019 |
| Spire Classic Cars Ltd | Wholesale & retail | 2012 |
| Spire Motor Company (Chesterfield) Limited | Wholesale & retail | 2012 |
| Spiria Limited | Professional & scientific | 2012 |