| South Yorkshire Property Rentals Ltd | Real estate | 2017 |
| South Yorkshire Property Services Ltd | Administrative & support | 2025 |
| South Yorkshire Property Trust Limited | Real estate | 1947 |
| South Yorkshire Refrigeration Ltd | Manufacturing | 2012 |
| South Yorkshire Roofing Repairs Limited | Construction | 2024 |
| South Yorkshire Senior Care Services Limited | Health & social care | 2006 |
| South Yorkshire Stoves & Fires Limited | Construction | 2026 |
| South Yorkshire Telecoms Limited | Information & communication | 2020 |
| South Yorkshire Washing Machine Hire Ltd | Administrative & support | 2018 |
| South Yorkshire Welding Supplies Limited | Manufacturing | 2012 |
| Southbank Atelier Limited | Real estate | 2011 |
| Southbank Events Limited | Hospitality | 2021 |
| Southbank Warehouse Limited | Wholesale & retail | 2009 |
| Southbeam Limited | Hospitality | 1977 |
| Southbourne Court Residents Association (Sheffield) Limited | Real estate | 1979 |
| Southbourne Mews Property Management Limited | Households | 1998 |
| Southbridge Building Supplies Limited | Real estate | 1980 |
| Southcliffe Ltd | Information & communication | 2012 |
| Southeng Solutions Limited | Professional & scientific | 2025 |
| Southerly Property Investments Limited | Real estate | 2020 |
| Southern Independent Group Ltd | Extraterritorial | 2022 |
| Southern Knight Capital Ltd | Professional & scientific | 2018 |
| Southern Wall Limited | Wholesale & retail | 2020 |
| Southern Workforce UK Limited | Wholesale & retail | 2004 |
| Southernwood Dore Limited | Construction | 2017 |
| Southey Chippy Limited | Hospitality | 2026 |
| SOUTHEY1972 Limited | Extraterritorial | 2013 |
| Southfield Creative Limited | Professional & scientific | 2022 |
| Southlake Park Limited | Arts & recreation | 2018 |
| Southlands Exploration Ltd | Mining & quarrying | 2017 |
| Southmedia Ltd | Professional & scientific | 2012 |
| Southport Golf Complex Limited | Real estate | 1987 |
| Southside Corporation Limited | Construction | 2014 |
| Sovereign Healthcare Locums Limited | Health & social care | 2022 |
| Sovereign Land Limited | Agriculture & fishing | 2018 |
| Sovereign Property Trust Limited | Agriculture & fishing | 1987 |
| Sovereign Stainless Fabrications Limited | Manufacturing | 1993 |
| Sovereign Steel Fencing Limited | Professional & scientific | 1963 |
| Sowell Limited | Wholesale & retail | 2021 |
| SOY Homes Ltd | Real estate | 2025 |
| Sozim Limited | Administrative & support | 2011 |
| SP GAS and Heating Services Limited | Construction | 2024 |
| SP Pubs Ltd | Hospitality | 2025 |
| SP1 Developments Ltd | Real estate | 2025 |
| Spa Landscaping Limited | Wholesale & retail | 2001 |
| Spa LIV Limited | Other services | 2022 |
| Spa View Community Church | Other services | 2013 |
| Space 205 Ltd | Wholesale & retail | 2022 |
| Space in the Circle Ltd | Professional & scientific | 2023 |
| Space IS the Place Ltd | Information & communication | 2014 |
| Space Sprint Limited | Information & communication | 2022 |
| Space to Breathe Community Interest Company | Wholesale & retail | 2017 |
| Space Venue Limited | Hospitality | 2018 |
| Spaced Digital Ltd | Information & communication | 2017 |
| Spacelogoai Ltd | Professional & scientific | 2024 |
| Spacemen 3 a Legal Matter Baby Ltd | Information & communication | 2021 |
| Spacepad Construction Limited | Construction | 2016 |
| Spacepad Design and Build Ltd | Other services | 2018 |
| Spaces Sheffield Limited | Real estate | 1990 |
| Spacesavers Logistics Limited | Real estate | 2018 |
| Spaceslide Limited | Extraterritorial | 2009 |
| Spacestar Digital Limited | Information & communication | 2021 |
| Spafix (Midlands & North) Ltd | Wholesale & retail | 2014 |
| Spain Kennedy Ltd | Manufacturing | 2025 |
| Span Corp Ltd | Manufacturing | 2003 |
| Span Property Ventures Limited | Real estate | 2024 |
| Sparc Technology Limited | Information & communication | 2025 |
| Sparesnap Ltd | Wholesale & retail | 2025 |
| Spark 1 Holdco Limited | Real estate | 2024 |
| Spark 1 Propco Limited | Real estate | 2024 |
| Spark 2 Holdco Limited | Real estate | 2025 |
| Spark 2 Propco Limited | Real estate | 2025 |
| Spark Academy Tutoring Limited | Education | 2024 |
| Spark Appliances Ltd | Wholesale & retail | 2023 |
| Spark Cafe Bar Limited | Hospitality | 2025 |
| Spark Media Partners North Ltd | Information & communication | 2020 |
| Spark Walsall Management Company Limited | Real estate | 2024 |
| Sparklers Fireworks Ltd | Wholesale & retail | 2023 |
| Sparkling Clauds Ltd | Administrative & support | 2024 |
| Sparklit Services Ltd | Administrative & support | 2020 |
| Sparkrena Limited | Information & communication | 2022 |
| Sparks Family Holdings Limited | Real estate | 2025 |
| Sparks Homes Limited | Construction | 2017 |
| Sparks LDC Limited | Wholesale & retail | 2022 |
| Sparks Managed Services Ltd | Administrative & support | 2011 |
| Sparks Properties Limited | Real estate | 1971 |
| Sparks Solutions Ltd | Education | 2014 |
| Sparks Teaching Services Ltd | Administrative & support | 2012 |
| Sparrk Electrical Limited | Construction | 2014 |
| Sparrk PV Ltd | Construction | 2022 |
| Sparrow Contractors Ltd | Hospitality | 2025 |
| Sparrow Searches Limited | Real estate | 2020 |
| Spartan Developments Ltd | Construction | 2019 |
| Spartan Ductwork Limited | Construction | 2026 |
| Spartan Engineering Limited | Manufacturing | 2001 |
| Spartan Logistics Limited | Transport & logistics | 2025 |
| Spartan Real Estates Ltd | Real estate | 2025 |
| Spartan Site Solutions Ltd | Construction | 2021 |
| Spartenz Limited | Wholesale & retail | 2025 |
| Spasov Limited | Transport & logistics | 2021 |