| SBA 25 Liverpool Limited | Real estate | 2025 |
| SBF Management Systems Ltd | Information & communication | 2026 |
| SBJ Estates Ltd | Hospitality | 2025 |
| Sbmd Estates Ltd. | Real estate | 2012 |
| Sboutique (Sheffield) Limited | Wholesale & retail | 2021 |
| SBR Race Management Limited | Arts & recreation | 2024 |
| Sbwy Ltd | Professional & scientific | 2017 |
| SBZ Properties Ltd | Real estate | 2022 |
| SC & H Properties Limited | Extraterritorial | 2017 |
| SC & JD Investments Ltd | Professional & scientific | 2026 |
| SC Advanced Health Ltd | Health & social care | 2022 |
| SC Autos Ltd | Wholesale & retail | 2024 |
| SC Buckley Limited | Health & social care | 2010 |
| SC Corporate Investments Limited | Hospitality | 2004 |
| SC Web Limited | Information & communication | 2025 |
| Scaff Security Alarms Limited | Administrative & support | 2009 |
| Scaffold Advocacy | Information & communication | 2025 |
| Scaife Finance and Business Solutions Ltd | Professional & scientific | 2014 |
| Scaife Group Ltd | Construction | 2021 |
| Scajen Eco Ltd | Construction | 2018 |
| Scala Properties Limited | Professional & scientific | 2019 |
| Scale CEO Consultancy Ltd | Professional & scientific | 2025 |
| Scallywags Nursery & Pre-School Limited | Education | 2002 |
| Scan Archive Shred Ltd | Transport & logistics | 2019 |
| Scandrive Limited | Extraterritorial | 2005 |
| Scanlon Contract Furnishings Limited | Real estate | 1976 |
| Scanmech Plant (Sales and Service) Limited | Wholesale & retail | 1981 |
| Scapan Ltd | Construction | 2024 |
| Scarangelli Ltd | Hospitality | 2025 |
| Scarborough Rentals Limited | Hospitality | 2020 |
| Scarcliffe Consultants Limited | Professional & scientific | 2021 |
| Scarlet Black Music Publishing Ltd | Information & communication | 2026 |
| Scarlet Ribbons Limited | Other services | 2002 |
| Scarpach Ltd | Real estate | 2020 |
| Scbc Ltd | Construction | 2010 |
| SCC BSF SPV Limited | Professional & scientific | 2007 |
| SCD Tours UK Limited | Other services | 2014 |
| SCD Tours Worldwide Ltd | Other services | 2021 |
| SCD TV Limited | Other services | 2022 |
| SCE Industries Holdings Limited | Professional & scientific | 2016 |
| SCE Industries Limited | Financial services | 2003 |
| SCE Property Group Limited | Real estate | 2026 |
| SCENE3D Ltd | Professional & scientific | 2018 |
| Scenic Colours Limited | Arts & recreation | 2008 |
| SCF Property Holdings Limited | Financial services | 2026 |
| SCG Industries Ltd | Wholesale & retail | 2021 |
| SCGU4 Hold Co Ltd | Health & social care | 2024 |
| SCGU4E Ltd | Health & social care | 2024 |
| SCH Logistics Solutions Ltd | Transport & logistics | 2009 |
| Schaeffler (UK) Limited | Manufacturing | 1955 |
| Schaeffler (UK) Pension Trustee Limited | Financial services | 2005 |
| Schema Codex Ltd | Information & communication | 2025 |
| Schickbites Ltd | Hospitality | 2024 |
| Schmelter Limited | Health & social care | 2024 |
| Scholar and Stone Ltd | Real estate | 2026 |
| Schon Design Ltd | Manufacturing | 2017 |
| School Food Solutions Ltd | Hospitality | 2013 |
| School House Recruitment South Yorkshire Ltd | Administrative & support | 2011 |
| School of Creative Business and Design Limited | Administrative & support | 2025 |
| School of Lash Ltd | Education | 2018 |
| School Road DS Limited | Health & social care | 2014 |
| School Room Climbing Limited | Arts & recreation | 2025 |
| Schooled in Music Limited | Arts & recreation | 2021 |
| Schools and Homes Energy Education Project | Education | 1996 |
| Schools Systems Care Limited | Wholesale & retail | 2011 |
| Schrute Farms Ltd | Real estate | 2020 |
| Schulke & Mayr UK Limited | Wholesale & retail | 1994 |
| SCI Semiconductor Limited | Manufacturing | 2023 |
| SCI Shef Co. Limited | Real estate | 2015 |
| Sci-Tech Water Treatment Ltd | Water & waste | 2016 |
| Science 4 Health Ltd | Information & communication | 2011 |
| Scientific Online Systems Limited | Information & communication | 2012 |
| Scientific Supplies PK Ltd | Wholesale & retail | 2022 |
| Scion Interiors Ltd | Manufacturing | 2021 |
| Scion Mortgages Ltd | Financial services | 2024 |
| Scissor Digital Limited | Information & communication | 2017 |
| SCL London Ltd | Construction | 2019 |
| SCM Legal Ltd | Professional & scientific | 2026 |
| SCM One Stop Services Limited | Hospitality | 2013 |
| Scootmusic Limited | Arts & recreation | 2007 |
| Scope Consulting (Yorkshire) Ltd | Professional & scientific | 2015 |
| Scoresby Cottage Holiday LET Ltd | Real estate | 2023 |
| Scorpion Construction & Development Ltd | Construction | 2024 |
| Scorpion Recruitment Services Ltd | Administrative & support | 2020 |
| Scotch Steak Houses Limited | Hospitality | 2003 |
| Scotia Health Care Limited | Health & social care | 2004 |
| Scotplas Limited | Extraterritorial | 1993 |
| Scott Adams Services Ltd | Hospitality | 2025 |
| Scott Anson Painters & Decorators Limited | Construction | 2003 |
| Scott Furniture Limited | Wholesale & retail | 2023 |
| Scott Jackson Contracting Limited | Other services | 2025 |
| Scott Road Store Ltd | Wholesale & retail | 2025 |
| Scott Robinson Consultancy Limited | Information & communication | 2013 |
| Scott Storage Limited | Transport & logistics | 2025 |
| Scott World Investment Ltd | Real estate | 2026 |
| Scott's Developments Limited | Construction | 2013 |
| Scott's Electrical Contractors Ltd | Administrative & support | 2014 |
| Scottchegg Limited | Manufacturing | 2024 |
| Scotts Barbers Ltd | Other services | 2015 |
| Scotts Packaging Limited | Administrative & support | 2017 |