| Sapphire Hotels Ltd | Hospitality | 2021 |
| Sapphire Leasing Ltd | Administrative & support | 2010 |
| Sapphire Portfolio Ltd | Real estate | 2016 |
| Sapphire Project Organisation | Education | 2020 |
| Sapphire Remainco Limited | Information & communication | 2010 |
| Saptagiribalaji Ltd | Hospitality | 2026 |
| SAQA22 Limited | Transport & logistics | 2025 |
| SAR Boxmakers Limited | Manufacturing | 2019 |
| SAR Interiors Limited | Construction | 2020 |
| SAR Planning Services Limited | Mining & quarrying | 2001 |
| Sara DE Bondt Limited | Arts & recreation | 2007 |
| Sara V Ltd | Wholesale & retail | 2026 |
| Sarah & Tate Limited | Health & social care | 2022 |
| Sarah Buildings Limited | Households | 2023 |
| Sarah Care Ltd | Health & social care | 2008 |
| Sarah Currer Ltd | Administrative & support | 2022 |
| Sarah Jappy Ltd | Information & communication | 2017 |
| Sarah Joanne Smith Ltd | Professional & scientific | 2019 |
| Sarah Jones IS Ltd | Information & communication | 2017 |
| Sarah Taylor Aesthetics Ltd | Health & social care | 2019 |
| Sarah Wilson Yoga Health and Wellbeing Limited | Other services | 2017 |
| Sarahmossart Ltd | Arts & recreation | 2024 |
| Sarahskitchen Ltd | Hospitality | 2009 |
| Saraj Imaging Ltd | Health & social care | 2021 |
| Sarari Limited | Wholesale & retail | 2020 |
| Sarca Engineering Ltd | Professional & scientific | 2019 |
| Sareena Investments Limited | Financial services | 2018 |
| Sari Giuliano Limited | Hospitality | 2023 |
| Saridag Ltd | Hospitality | 2025 |
| Sarita Wadkin Psychotherapy & Wellbeing Limited | Health & social care | 2026 |
| Sarjeant Electrical Ltd | Construction | 2025 |
| Sarr Diouf Logistics Limited | Transport & logistics | 2026 |
| Sarrac Ltd | Information & communication | 2025 |
| Sartak Travel and Tours Ltd | Administrative & support | 2023 |
| SAS Cladding and Roofing Services Limited | Construction | 2025 |
| SAS Competitions Limited | Arts & recreation | 2026 |
| SAS Direct Services Limited | Real estate | 2016 |
| SAS GAS Services Ltd | Construction | 2021 |
| SAS Gutter Clearing Ltd | Administrative & support | 2023 |
| SAS Letting & Real Estate Limited | Real estate | 2021 |
| SAS Rooflights Ltd | Construction | 2025 |
| Sasbone Limited | Health & social care | 2009 |
| Sasha Global 4U Ltd | Wholesale & retail | 2026 |
| Sassi Healthcare Limited | Health & social care | 2010 |
| Sassy Little Minx Ltd | Manufacturing | 2018 |
| Sata Properties (SY) Ltd | Real estate | 2025 |
| Satchmo Limited | Real estate | 2026 |
| Saturbaitsuk Limited | Wholesale & retail | 2025 |
| Saturn Machine Knives Limited | Manufacturing | 2002 |
| Saturstays Limited | Real estate | 2026 |
| Saudi Homes Ltd | Extraterritorial | 2026 |
| Saudi Properties Ltd | Extraterritorial | 2025 |
| Sauk BPO Consultants Limited | Information & communication | 2025 |
| Saul Farm Livery Ltd | Agriculture & fishing | 2020 |
| Saul Group Limited | Financial services | 2021 |
| Saul Property Services Ltd | Real estate | 2022 |
| Saul Security Services Limited | Administrative & support | 2017 |
| Saunafolk Limited | Other services | 2025 |
| Saunders & Co (Sheffield) Limited | Extraterritorial | 2013 |
| SAV Interiors Ltd | Construction | 2024 |
| SAV Property Limited | Real estate | 2022 |
| Savalyam Ltd | Information & communication | 2021 |
| Savant Consulting Limited | Wholesale & retail | 2021 |
| Save Productions Limited | Administrative & support | 2023 |
| Savemore Wincobank Ltd | Wholesale & retail | 2023 |
| Savers Homestore Ltd | Wholesale & retail | 2023 |
| Savi Technology Ltd | Hospitality | 2023 |
| Savills Mens Hairdressing Limited | Other services | 2009 |
| Savills Retail Limited | Wholesale & retail | 2013 |
| Saviour Cycling Apparel Ltd | Wholesale & retail | 2021 |
| Savoir Clean Company Limited | Administrative & support | 2025 |
| Savora Healthcare Ltd | Health & social care | 2023 |
| Savvy JOS Ltd | Construction | 2017 |
| SAW 56 Food Limited | Hospitality | 2026 |
| SAW Media Services Ltd | Other services | 2022 |
| Sawarner Solutions Limited | Professional & scientific | 2024 |
| Sawdesingn Limited | Wholesale & retail | 2021 |
| Sawrightconsultancy Limited | Professional & scientific | 2020 |
| Sawtech Services Limited | Administrative & support | 2008 |
| Saxby Brands Ltd | Wholesale & retail | 2026 |
| Saxon GB Trading Limited | Hospitality | 2017 |
| Saxon Group Limited | Hospitality | 2025 |
| Saxon Hotels Limited | Hospitality | 2000 |
| Saxton MEE (New Homes) Limited | Real estate | 2000 |
| Saxton MEE Commercial Limited | Real estate | 1999 |
| Saxton MEE Crookes Limited | Real estate | 2020 |
| Saxton MEE Limited | Real estate | 2008 |
| SAY IT With Cookie Ltd | Manufacturing | 2025 |
| SAY Paloma Ltd | Wholesale & retail | 2018 |
| Sayers Yard Management Company Limited | Extraterritorial | 1994 |
| Saynor Medtech Ltd | Wholesale & retail | 2025 |
| Sayrae Limited | Professional & scientific | 2025 |
| SB Contractors Ltd | Health & social care | 2025 |
| SB Convenience Stores Ltd | Wholesale & retail | 2022 |
| SB Lite Ltd | Wholesale & retail | 2011 |
| SB Meadowhall Ltd | Hospitality | 2026 |
| SB Oldfield Ltd | Health & social care | 2023 |
| SB Software Limited | Information & communication | 2007 |
| SB78 Ltd | Professional & scientific | 2016 |
| SBA 25 Limited | Hospitality | 2025 |