| Same YET Inn Simister Limited | Hospitality | 2016 |
| Sameday Courier Express Limited | Transport & logistics | 2012 |
| Samfabs Metal Works Ltd | Manufacturing | 2024 |
| Samfos Health & Trading Company Ltd | Administrative & support | 2011 |
| Samfos Health Ltd | Administrative & support | 2023 |
| Sami Chef Ltd | Hospitality | 2025 |
| Samia Oral Care Ltd | Health & social care | 2026 |
| Samir Patel Limited | Real estate | 2016 |
| Samis Logistics & Coaches Limited | Administrative & support | 2017 |
| Samis Superfoods Ltd | Wholesale & retail | 2021 |
| Samis UFC Limited | Hospitality | 2025 |
| Sammat Ltd | Real estate | 2024 |
| Sampo Transformation Ltd | Education | 2023 |
| Sampson Construction Limited | Construction | 2021 |
| Sampsons Coaching Ltd | Other services | 2026 |
| Samra Properties Ltd | Real estate | 2024 |
| Samrath Logistics Ltd | Transport & logistics | 2026 |
| Samrthi Stores Ltd | Wholesale & retail | 2025 |
| Sams Barbers Ltd | Other services | 2026 |
| Sams Global Solutions Ltd | Information & communication | 2019 |
| Sams Traditional Barber Limited | Other services | 2023 |
| Samson Pallet Stability Ltd | Administrative & support | 1984 |
| Samson Propertie Services Ltd | Real estate | 2022 |
| Samson S Accountancy Limited | Professional & scientific | 2015 |
| Samsop 1 Limited | Real estate | 2023 |
| Samsop 2 Limited | Real estate | 2025 |
| Samsop Holdings Limited | Financial services | 2023 |
| Samuel Eales Silverware Limited | Manufacturing | 1991 |
| Samuel Huston Limited | Professional & scientific | 2019 |
| Samuel Peace (International) Limited | Wholesale & retail | 1996 |
| Samuel Worth Chapel Limited | Hospitality | 2024 |
| Samuel's Stocksbridge Limited | Hospitality | 2015 |
| Samuels Properties Ltd | Real estate | 2024 |
| Samui PUB Co Ltd | Hospitality | 2019 |
| Samui Weddings Ltd | Other services | 2016 |
| Samurai Digital Security Limited | Professional & scientific | 2016 |
| Samy Pharma Solutions Ltd | Health & social care | 2024 |
| Sancak Ltd | Hospitality | 2025 |
| Sanctified Homes Ltd | Administrative & support | 2022 |
| Sandal Construction Ltd | Construction | 2024 |
| Sandal Developments Ltd | Construction | 2025 |
| Sandal Holdings Ltd | Financial services | 2025 |
| Sandal Properties Ltd | Real estate | 2023 |
| Sande Time Limited | Other services | 2023 |
| Sanderson International Limited | Arts & recreation | 2015 |
| Sandersons Department Stores Limited | Wholesale & retail | 2015 |
| Sandford House Limited | Health & social care | 2004 |
| Sandhu Foods Limited | Hospitality | 2023 |
| Sandhu Housing Ltd | Real estate | 2021 |
| Sandiacre Precision Engineering Limited | Manufacturing | 2004 |
| Sandla Group Limited | Financial services | 2024 |
| Sando Catering Services Limited | Hospitality | 2023 |
| Sando Holdings Limited | Financial services | 2024 |
| Sandprint Games Limited | Manufacturing | 2026 |
| Sandstone Convenience Store Ltd | Wholesale & retail | 2017 |
| Sandtoft Land Investments Ltd | Real estate | 2025 |
| Sandwich Box Hellaby Limited | Hospitality | 2023 |
| Sandwich Junction Ltd | Hospitality | 2015 |
| Sandwich King Limited | Information & communication | 2025 |
| Sandycott Limited | Manufacturing | 1982 |
| Sandygate Food Ltd | Hospitality | 2025 |
| Sandygate Mavens Ltd | Other services | 2016 |
| Sandygate Physiotherapy Limited | Health & social care | 2022 |
| Sandygate Tech Limited | Information & communication | 2017 |
| Saneth Limited | Health & social care | 2009 |
| Sanethcare Limited | Health & social care | 2022 |
| Sang Lung Takeaway Limited | Hospitality | 2020 |
| Sangams Balti Ltd | Hospitality | 2020 |
| Sangams Food Limited | Hospitality | 2025 |
| Sangawe Immigration Service Limited | Professional & scientific | 2021 |
| Sanguis Opus Limited | Wholesale & retail | 2024 |
| Sani Convenience Ltd | Wholesale & retail | 2023 |
| Sanijah Essentials Ltd | Wholesale & retail | 2025 |
| Saniq Ltd | Information & communication | 2026 |
| Sanjeev Sharma Ltd | Health & social care | 2015 |
| Sankanban Ltd. | Professional & scientific | 2017 |
| Sanksthetics Ltd | Health & social care | 2024 |
| Sanlian-Acme Limited | Financial services | 2014 |
| Sanoderm Limited | Professional & scientific | 2020 |
| Sanpho Pension Trustees Limited | Extraterritorial | 1980 |
| Sansa Limited | Wholesale & retail | 2026 |
| Sansanima Limited | Professional & scientific | 2024 |
| Santhi Medical Limited | Health & social care | 2022 |
| Santo Consultancy Services Ltd | Professional & scientific | 2023 |
| Santos Security Ltd | Administrative & support | 2021 |
| Santrad Online Ltd | Wholesale & retail | 2015 |
| SAP Structural Ltd | Professional & scientific | 2019 |
| Sapeasy Limited | Extraterritorial | 2024 |
| Saphala Secretarial Services Limited | Administrative & support | 2006 |
| Saphex Limited | Manufacturing | 2015 |
| Saphina Marshall Limited | Households | 2021 |
| Sapien Aerospace Limited | Professional & scientific | 2020 |
| Sapien Studio Ltd | Professional & scientific | 2022 |
| Sapient Motors Ltd | Wholesale & retail | 2019 |
| Sapphire Contracts (Northern) Limited | Wholesale & retail | 2009 |
| Sapphire Contracts (Southern) Limited | Wholesale & retail | 2009 |
| Sapphire Estate and Letting Ltd | Real estate | 2024 |
| Sapphire EVENTSS6 Limited | Hospitality | 2025 |
| Sapphire Floors Limited | Construction | 2009 |
| Sapphire Hardware Limited | Wholesale & retail | 2004 |