| Scotts Transportation Ltd | Transport & logistics | 2013 |
| SCP Intl Limited | Information & communication | 2025 |
| SCR Financial Interventions Holding Company Ltd | Professional & scientific | 1985 |
| SCR Ticketing Company Limited | Transport & logistics | 2017 |
| Scram and Scrum Ltd | Arts & recreation | 2023 |
| Scrannery Ltd | Hospitality | 2024 |
| Scrap Dragon CIC | Wholesale & retail | 2015 |
| Scrapbook Development Limited | Information & communication | 2012 |
| Scraqe General Ltd | Financial services | 2020 |
| Scratch N Shine Limited | Wholesale & retail | 2025 |
| Scream Retail Newport Ltd | Wholesale & retail | 2018 |
| Script UK Ltd | Health & social care | 2007 |
| Scripted Finance Ltd | Information & communication | 2024 |
| Scrivenhouse Investments Limited | Real estate | 2022 |
| Scrudf Limited Partnership | | 2012 |
| Scrumps Limited | Information & communication | 2023 |
| Scrumptious by Lucy Ltd | Hospitality | 2022 |
| Scrypted Cards Ltd | Wholesale & retail | 2026 |
| SCS Auto Services Ltd | Wholesale & retail | 2017 |
| SCS Cars Limited | Wholesale & retail | 2013 |
| SCS Salvage Limited | Wholesale & retail | 2019 |
| SCS Trans Ltd | Transport & logistics | 2018 |
| Scse UK Ltd. | Administrative & support | 2025 |
| Scuff 2 Buff Cosmetic Repairs Limited | Wholesale & retail | 2022 |
| Scuffs ETC Ltd | Wholesale & retail | 2024 |
| Scullion and Scot Ltd | Other services | 2020 |
| Sculpt Fitness Studios Ltd | Arts & recreation | 2017 |
| Sculpt Transformations Ltd | Arts & recreation | 2025 |
| SCX Kinetic Limited | Professional & scientific | 2019 |
| SCX Special Projects Holdings Limited | Professional & scientific | 2016 |
| SCX Special Projects Limited | Manufacturing | 2010 |
| SD 89 Solutions Ltd | Administrative & support | 2016 |
| SD Auto Electrical Services Limited | Wholesale & retail | 2022 |
| SD Cunstruction Ltd | Construction | 2021 |
| SD Microbe Manager Ltd | Health & social care | 2018 |
| SD Motorcycles Limited | Wholesale & retail | 2013 |
| SD Plant Maintenance Ltd | Wholesale & retail | 2023 |
| SD Towers SPV Ltd | Real estate | 2021 |
| SD89 Holdings Ltd | Extraterritorial | 2012 |
| SDA Investments Limited | Professional & scientific | 2009 |
| Sdaveimpex Limited | Wholesale & retail | 2025 |
| SDC ENT Ltd | Health & social care | 2018 |
| Sdcm Group Ltd | Wholesale & retail | 2011 |
| SDG Editors Ltd | Information & communication | 2024 |
| SDG1 Properties Ltd | Construction | 2026 |
| SDH Commerce Ltd | Wholesale & retail | 2026 |
| SDL Propco Ltd | Real estate | 2026 |
| SDP (Yorkshire) Ltd | Construction | 2017 |
| SDP Lettings and Management Limited | Real estate | 2024 |
| Sdruryelectrical Limited | Construction | 2015 |
| SDS (Yorkshire) Ltd | Construction | 2014 |
| SDS Alloys & Metals Ltd | Professional & scientific | 2021 |
| SDX Construction Ltd | Construction | 2025 |
| SDX Property Holdings Ltd | Financial services | 2025 |
| Sea Otter Workboats Limited | Energy | 1993 |
| Sea Star Moon Ltd | Wholesale & retail | 2025 |
| Sea the Star Ltd | Hospitality | 2025 |
| Sea View Lodges Limited | Hospitality | 2022 |
| Seabourne Scarborough Limited | Hospitality | 2021 |
| Seabrook Property Ltd | Construction | 2021 |
| Seachelle Consulting Limited | Professional & scientific | 2014 |
| Seaden Properties Ltd | Construction | 2025 |
| Seadream Scarborough Limited | Hospitality | 2020 |
| Sealman Limited | Extraterritorial | 2016 |
| Seaman Photographer Limited | Professional & scientific | 1974 |
| Seamless Aluminium Gutter Supplies Limited | Manufacturing | 2025 |
| Seamless Gutter Company Limited | Construction | 2005 |
| Seamless Waterproofing Solutions Ltd | Construction | 2024 |
| Sean&T Ltd | Construction | 2025 |
| Seas and Skys Ltd | Hospitality | 2025 |
| Seascape Scarborough Limited | Hospitality | 2020 |
| Seaside Getsways Limited | Hospitality | 2024 |
| Seaside Spirit Limited | Administrative & support | 2007 |
| Season & Co. Enterprise Ltd | Manufacturing | 2026 |
| Seasons by Rangz Limited | Wholesale & retail | 2026 |
| Seats Cover Limited | Manufacturing | 2024 |
| Seaview Sensing Limited | Information & communication | 2004 |
| SEB Drylining Ltd | Construction | 2010 |
| Sebasouthwell Ltd | Information & communication | 2026 |
| Sebastian Brown Voices Limited | Administrative & support | 2025 |
| Sebi Project Limited | Wholesale & retail | 2020 |
| Sebig Ltd | Transport & logistics | 2021 |
| Sebplus Ltd | Administrative & support | 2025 |
| Second Chapter Limited | Administrative & support | 2021 |
| Second Nature Studio Ltd | Professional & scientific | 2024 |
| Second Sitting Ltd | Wholesale & retail | 2020 |
| Secondhandgarms Limited | Wholesale & retail | 2025 |
| Secprint Limited | Manufacturing | 1998 |
| Secret Cake Club Ltd | Hospitality | 2022 |
| Secret DOT Limited | Wholesale & retail | 2025 |
| Secret Joinery Limited | Construction | 2015 |
| Secret Meet Limited | Other services | 2020 |
| Secure Alpha Security Services Limited | Administrative & support | 2023 |
| Secure Currencies Ltd | Financial services | 2023 |
| Secure Guard Limited | Administrative & support | 2021 |
| Secure Labs Ltd | Information & communication | 2025 |
| Secure Media Services Limited | Transport & logistics | 2015 |
| Secure Power Ltd | Professional & scientific | 2009 |
| Secure Renewables Ltd | Energy | 2019 |
| Secure Services (Yorkshire) Ltd | Administrative & support | 2023 |