| Elite Hand Car Wash Scunthorpe Limited | Other services | 2019 |
| Elite Medical Cover Ltd | Health & social care | 2024 |
| Elite Motor Services Limited | Wholesale & retail | 2002 |
| Elite Personal Training and Classes Limited | Arts & recreation | 2016 |
| Elite Properties and Let’S Ltd | Real estate | 2025 |
| Elite Stock Ltd | Administrative & support | 2017 |
| Elite-Ascent Ltd | Professional & scientific | 2024 |
| Elitedevelopmentsandhomes Ltd | Construction | 2022 |
| Ella Food Store Ltd | Wholesale & retail | 2026 |
| Ella Store Ltd | Wholesale & retail | 2024 |
| Ellcado Finance Limited | Financial services | 2024 |
| Elliott Optimum Solutions Ltd | Administrative & support | 2016 |
| Elliott’S ENG Ltd | Manufacturing | 2025 |
| Ellko Supermarket Limited | Wholesale & retail | 2023 |
| Ellsi Limited | Manufacturing | 2019 |
| Elmwood Flooring Ltd | Wholesale & retail | 2016 |
| Eltoro Cafe Limited | Hospitality | 2018 |
| Elwira Transport Ltd | Transport & logistics | 2023 |
| Embur Events Ltd | Hospitality | 2019 |
| Emenys Ltd | Wholesale & retail | 2024 |
| Emerald Safety and Occupational Health Consultants Limited | Professional & scientific | 2012 |
| EMG Creations Limited | Other services | 2023 |
| EMG Precision Ltd | Wholesale & retail | 2020 |
| Emily's Apps Limited | Information & communication | 2016 |
| EMJ Plastics Limited | Manufacturing | 1960 |
| Emka Sells Ltd | Wholesale & retail | 2025 |
| Emma Moraes Limited | Other services | 2008 |
| Empire (Cleethorpes) Trading Ltd | Wholesale & retail | 2024 |
| Empson Group Holdings Limited | Financial services | 2016 |
| Emque Limited | Professional & scientific | 2016 |
| Emrys Digital Limited | Information & communication | 2024 |
| Em’S Business Ltd | Wholesale & retail | 2023 |
| Encore Rooms Limited | Hospitality | 2020 |
| Enduro Products Ltd | Administrative & support | 2021 |
| Enerco Developments Ltd | Real estate | 2020 |
| Enerco Ltd | Construction | 2017 |
| Energy Point Electrical Ltd | Professional & scientific | 2026 |
| Energy Saving Windows Limited | Construction | 2010 |
| Energy@Nes Limited | Energy | 2018 |
| Enforce Electrical, Fire and Security Limited | Construction | 2018 |
| Enforce Specialist Security Solutions Limited | Administrative & support | 2012 |
| ENG Autos Limited | Wholesale & retail | 2025 |
| Engine for Change Ltd | Professional & scientific | 2026 |
| Engineering UTC Northern Lincolnshire | Education | 2013 |
| Englezu BIA Transport Ltd | Transport & logistics | 2025 |
| ENI Logistics Ltd | Transport & logistics | 2026 |
| ENS Precision Engineering Ltd | Manufacturing | 2023 |
| Ensco 1521 Limited | Professional & scientific | 2023 |
| ENT & Sleep Limited | Health & social care | 2020 |
| ENT Private Consultant Ltd | Health & social care | 2021 |
| ENT Sinus Surgeon Ltd | Health & social care | 2024 |
| ENTERTAINMENT24SCUNTHOPE Limited | Hospitality | 2024 |
| EP Independent Consultants Ltd | Professional & scientific | 2022 |
| Epic Occasions Ltd | Administrative & support | 2026 |
| EPS Engineering Ltd | Professional & scientific | 2016 |
| Epworth Foot Health Clinic Ltd | Health & social care | 2026 |
| Epworth Kitchen Ltd | Hospitality | 2025 |
| EQ. Medical Ltd | Health & social care | 2013 |
| Equestwell Ltd | Other services | 2025 |
| Erect & Clad Services Ltd | Construction | 2024 |
| Eric Tobin and Associates Limited | Professional & scientific | 2009 |
| Eric's Investments Limited | Real estate | 2012 |
| Erik Transport Logistic Ltd | Transport & logistics | 2026 |
| Ermine Private Hire Limited | Transport & logistics | 2024 |
| Esanyang Ltd | Professional & scientific | 2026 |
| Esmerin Properties Limited | Real estate | 2025 |
| Esociandgo’S Ltd | Health & social care | 2019 |
| Espresso Estate Ltd | Wholesale & retail | 2026 |
| Essence Flowers Ltd | Other services | 2013 |
| Essential Building and Maintenance Ltd | Construction | 2026 |
| Estia AAH Limited | Real estate | 2024 |
| Estuary Petals Limited | Administrative & support | 2015 |
| ET Hot Foods Ltd | Hospitality | 2025 |
| ET Property Solutions Limited | Real estate | 2019 |
| ET STS Group Ltd | Administrative & support | 2018 |
| ET STS Ltd | Administrative & support | 2019 |
| ETL Catering Ltd | Hospitality | 2021 |
| Eton Meal Ltd | Hospitality | 2025 |
| ETS Align Limited | Health & social care | 2012 |
| EU Food Store Limited | Wholesale & retail | 2018 |
| Euro Access Ltd | Manufacturing | 2020 |
| Euro Plant and Powered Access Ltd | Manufacturing | 2024 |
| Euroflex Fibc Limited | Wholesale & retail | 2017 |
| EUROHAUL77 Ltd | Transport & logistics | 2026 |
| Europ@ Solutions Ltd | Professional & scientific | 2020 |
| European Market DAN Ltd | Wholesale & retail | 2015 |
| Euvic Services Ltd | Information & communication | 2015 |
| EVA Carriage Ltd | Transport & logistics | 2025 |
| Evanje Company Limited | Health & social care | 2015 |
| Evans Endeavours Ltd | Real estate | 2025 |
| Evening Cat Productions Ltd | Information & communication | 2024 |
| Event Marquees Ltd | Administrative & support | 2014 |
| Everyday Equestrian Co. Ltd | Wholesale & retail | 2026 |
| Evlat Foods Ltd | Hospitality | 2024 |
| Evolve Business Developments Limited | Administrative & support | 2012 |
| Evolve Chiropractic & Wellness Ltd | Health & social care | 2025 |
| Excel Excel Fisheries Ltd | Hospitality | 2026 |
| Excel Fisheries Limited | Hospitality | 2022 |
| Exceptional Business Limited | Construction | 2020 |
| Exclusive Hot Tubs Ltd | Wholesale & retail | 2026 |