| DT Contracting Beet Ltd | Agriculture & fishing | 2018 |
| DTC Homecare Limited | Health & social care | 2018 |
| DTW Planning Solutions Limited | Professional & scientific | 2014 |
| DUA Investments Ltd | Real estate | 2020 |
| Dubshack Ltd | Real estate | 2019 |
| Duckett Road Limited | Real estate | 1999 |
| Dudzic Transport Ltd | Transport & logistics | 2025 |
| Dukes Garage Limited | Wholesale & retail | 2022 |
| Dunbar Group Limited | Construction | 2023 |
| Dunne and Co Asset Limited | Financial services | 2025 |
| Durning & Hunt Developments Limited | Construction | 2017 |
| Dustydiscs Ltd | Wholesale & retail | 2024 |
| Dutch Fire Protection Limited | Public administration | 2025 |
| DVP Ultrasound Service Ltd | Health & social care | 2025 |
| DW Properties Ltd | Construction | 2024 |
| DWJ Transport Ltd | Transport & logistics | 2020 |
| DWW Plumbing and Heating Ltd | Construction | 2021 |
| DWW Properties Ltd | Real estate | 2024 |
| Dwyer Gaming Limited | Information & communication | 2015 |
| Dyson Transport Services Limited | Transport & logistics | 2008 |
| E & a OFF Licence Ltd | Wholesale & retail | 2017 |
| E B Parker Ltd | Information & communication | 2024 |
| E Type Parts Limited | Wholesale & retail | 2013 |
| E&I Project Engineering Ltd | Professional & scientific | 2022 |
| E-Key Limited | Manufacturing | 2018 |
| E-Vehicle Chargers Ltd | Construction | 2023 |
| E.Shop.Mash.Up Ltd | Wholesale & retail | 2024 |
| Eaat Consulting Ltd | Health & social care | 2025 |
| EAD Transport UK Ltd | Transport & logistics | 2026 |
| Eadens Ltd | Wholesale & retail | 2008 |
| EAF Engineering Limited | Professional & scientific | 2017 |
| Eagle Roofing and PVC Limited | Construction | 2025 |
| Early Cleanse Limited | Administrative & support | 2019 |
| East Kent Cardiology Ltd | Professional & scientific | 2015 |
| East Midlands Education Services Limited | Education | 2012 |
| East Trent Ltd | Administrative & support | 2013 |
| East Yorkshire Breast Clinic Ltd | Health & social care | 2013 |
| East Yorkshire Roofing & Cladding Limited | Construction | 2020 |
| Easy Code Ltd | Information & communication | 2018 |
| Easy Move Property Ltd | Real estate | 2019 |
| Easygrub Ltd | Information & communication | 2023 |
| Eaton Homes Limited | Construction | 2002 |
| EBA Medical UK Limited | Health & social care | 2021 |
| Ebdagnyte Logistics Ltd | Transport & logistics | 2018 |
| Ebony & Ivory Garage Ltd | Wholesale & retail | 2019 |
| Ebony & Ivory Motors Limited | Wholesale & retail | 2002 |
| Echo Doctor Ltd | Health & social care | 2016 |
| ECI Consultancy Services Limited | Professional & scientific | 2017 |
| Eclipse Doors Direct Limited | Manufacturing | 2022 |
| Eclipse World Limited | Manufacturing | 1998 |
| Eco Mdrive Ltd | Transport & logistics | 2017 |
| Eco Recycling Group Ltd | Water & waste | 2017 |
| Ecoleaf Energy Ltd | Construction | 2024 |
| Ecoluxe Cleaning Services Ltd | Administrative & support | 2025 |
| Ecotech Holdings Limited | Financial services | 2021 |
| Ecstm Ltd | Public administration | 2024 |
| Eden Consultancy Limited | Information & communication | 2026 |
| Eden Healthwise Limited | Financial services | 2023 |
| Eden Mobility Limited | Wholesale & retail | 2004 |
| Edge Ecom Limited | Wholesale & retail | 2025 |
| Edge Interactive Limited | Administrative & support | 2003 |
| Edge-Ctrl Solutions Ltd | Professional & scientific | 2024 |
| Edgemont Urology Limited | Health & social care | 2023 |
| Edit Skin Ltd | Other services | 2025 |
| EDK Parts Ltd | Wholesale & retail | 2025 |
| Education With a... CIC | Other services | 2018 |
| Edupaws Ltd | Education | 2025 |
| EDY & Luca Spedition Ltd | Transport & logistics | 2019 |
| EDY Ianis Transport Ltd | Transport & logistics | 2023 |
| EE Property Lettings Ltd | Real estate | 2024 |
| Efgs Holdings Limited | Real estate | 2025 |
| Egidatransport Group Ltd | Transport & logistics | 2026 |
| Egista Limited | Transport & logistics | 2018 |
| Egjmedical Ltd | Health & social care | 2018 |
| EGM Trans Ltd | Transport & logistics | 2022 |
| Egos Environmental Ltd | Professional & scientific | 2019 |
| Ehab Badran Ltd | Professional & scientific | 2025 |
| Ehmotion Design Ltd. | Information & communication | 2014 |
| EJC Wind Ltd | Professional & scientific | 2025 |
| EJK Aesthetics & Beauty Ltd | Other services | 2023 |
| EK Metalworks Ltd | Manufacturing | 2026 |
| Ekro Limited | Wholesale & retail | 2022 |
| Ekspla UK Ltd | Wholesale & retail | 2018 |
| El-Tel, Properties Ltd | Real estate | 2020 |
| Elaine Turner Limited | Other services | 2008 |
| Eldar Construction Ltd | Administrative & support | 2025 |
| Eldoret Health Limited | Health & social care | 2023 |
| ELE Ltd | Transport & logistics | 2024 |
| Elefantu Structures Limited | Construction | 2025 |
| Elegant Homes (York) Limited | Construction | 2003 |
| Element Animation Ltd | Information & communication | 2012 |
| Elevate Build Solutions Limited | Construction | 2026 |
| Eleven 07 Architectural Design Ltd | Professional & scientific | 2024 |
| Elilocks Limited | Other services | 2026 |
| Eliluka Transport Ltd | Transport & logistics | 2025 |
| Elite Autos a Limited | Extraterritorial | 2018 |
| Elite Care Solutions Ltd | Health & social care | 2010 |
| Elite Civils Projects Limited | Construction | 2023 |
| Elite Discount Tile Warehouse Limited | Wholesale & retail | 2002 |
| Elite Fire and Rescue Services Limited | Public administration | 2017 |