| Milford DEL Support Agency Limited | Health & social care | 2003 |
| Minchin Engineering Limited | Professional & scientific | 2006 |
| MK1 Kitchens Limited | Wholesale & retail | 2011 |
| MM2ANNEX Ltd | Real estate | 2025 |
| Modern Landscapes Ltd | Administrative & support | 2023 |
| Mono Cyberconsulting Ltd | Information & communication | 2019 |
| Mountain Tours Ltd | Administrative & support | 2005 |
| MPW Aeroservices Limited | Manufacturing | 2003 |
| MS Friday Accountancy Services Ltd | Professional & scientific | 2018 |
| Mumbaibites BD Ltd | Hospitality | 2023 |
| Muzza's Limited | Hospitality | 2014 |
| MWR Blades Ltd | Manufacturing | 2024 |
| My Aero Leasing Ltd | Administrative & support | 2019 |
| MYL Sandown Limited | Hospitality | 2014 |
| NAB Marketing Ltd | Professional & scientific | 2022 |
| Needle & Tide Ltd | Wholesale & retail | 2025 |
| New Way Consulting Limited | Agriculture & fishing | 2004 |
| Next Wave Care Group Limited | Health & social care | 2025 |
| Nigh Race Engineering Limited | Professional & scientific | 2023 |
| Ninyonga Couture Ltd | Wholesale & retail | 2022 |
| Noohn Consulting Ltd | Information & communication | 2025 |
| North Road Garage (IW) Limited | Wholesale & retail | 2003 |
| Northstar Conversions Limited | Wholesale & retail | 2014 |
| Northwood Payroll Services Limited | Professional & scientific | 1999 |
| Oakdene Residential Lettings Limited | Real estate | 2018 |
| Ocean Marketing (Europe) Limited | Administrative & support | 2003 |
| Oceanside Recruitment Limited | Administrative & support | 2023 |
| Olivetina Property Limited | Real estate | 2007 |
| ON the Island Laundry Ltd | Other services | 2023 |
| Onward Developments IOW Limited | Construction | 2019 |
| Onward Group Holdings Limited | Financial services | 2021 |
| Onward Offices Limited | Real estate | 2018 |
| Onward Waste Limited | Water & waste | 2020 |
| Open Mind Psychology Ltd | Health & social care | 2024 |
| Oren Interiors Ltd | Wholesale & retail | 2023 |
| Oropesa Outsourcing Limited | Information & communication | 2001 |
| P.B.M. & D. Limited | Real estate | 1999 |
| Paddleboarding London Ltd | Education | 2021 |
| Pantera Leone Group Limited | Wholesale & retail | 2026 |
| Pawmiapaws Ltd | Wholesale & retail | 2025 |
| Pawsitive IOW Ltd | Other services | 2020 |
| PCM Estates UK Limited | Real estate | 2023 |
| PE Composite Technologies Limited | Professional & scientific | 2010 |
| Pells Performance Ltd | Wholesale & retail | 2025 |
| Peninsula Neurosurgery Ltd | Health & social care | 2023 |
| Peregrine Computing Service Limited | Information & communication | 2015 |
| Peter Bridges Sound Limited | Information & communication | 2015 |
| Petro Procurement (UK) Limited | Administrative & support | 2007 |
| PGF Development Ltd | Construction | 2013 |
| Phenix Retreats Ltd | Arts & recreation | 2018 |
| Phenix Yoga Limited | Other services | 2014 |
| Pheonix Interiors & Staging Ltd | Construction | 2025 |
| Picture Language Limited | Extraterritorial | 2001 |
| Pinnacle IW LLP | | 2015 |
| Pitts Farm (IOW) Ltd | Agriculture & fishing | 2024 |
| Planning & Development Hub (IW) Limited | Extraterritorial | 2015 |
| Plaza Ices Limited | Wholesale & retail | 2007 |
| Plumb Stone Surveyors Ltd | Administrative & support | 2005 |
| PM Electronics UK Ltd | Manufacturing | 2009 |
| PM Property UK Ltd | Manufacturing | 2009 |
| Pollard Inns Limited | Hospitality | 2002 |
| Polychrest B Ltd. | Professional & scientific | 2015 |
| Polychrest Limited | Administrative & support | 2023 |
| Portsdown Health & Beauty Limited | Other services | 2003 |
| Prem Build Ltd | Construction | 2024 |
| Premium Rental Stays Limited | Real estate | 2023 |
| Primary Care Podiatry Ltd | Health & social care | 2022 |
| Pro-Aviation Limited | Transport & logistics | 1999 |
| Pro-Touch Paintless Dent Repair Ltd | Wholesale & retail | 2019 |
| Process Productions Limited | Information & communication | 2006 |
| Programme Support Services Limited | Professional & scientific | 2006 |
| Propertiez Limited | Real estate | 2023 |
| Quad Core Training Ltd | Education | 2015 |
| R&L Annis Ltd | Hospitality | 2024 |
| R.S Stoves Ltd | Construction | 2018 |
| Rail Vehicle Consultancy Ltd | Transport & logistics | 2009 |
| Rainbow Properties (Northern) Limited | Real estate | 1984 |
| Ralcomposites Limited | Manufacturing | 2023 |
| Ravi Dixit Yoga Ltd | Education | 2025 |
| Ravi Yoga Retreats Ltd | Administrative & support | 2025 |
| RB Hospitality Isle of Wight Ltd | Hospitality | 2020 |
| Rbraverywind Ltd | Manufacturing | 2026 |
| RDC Digital Consultancy Ltd | Information & communication | 2018 |
| Real Employment Law Advice Limited | Professional & scientific | 2016 |
| Reloved Homes IOW Limited | Real estate | 2025 |
| Research Grants Consulting and Service Limited | Administrative & support | 2015 |
| Resin Vault Ltd | Professional & scientific | 2024 |
| Resist and Renew Ltd | Administrative & support | 2021 |
| Rgsj Ltd | Other services | 2025 |
| Rhames Consulting Limited | Information & communication | 2006 |
| Ribban Limited | Administrative & support | 2006 |
| Riverford Publishing Ltd | Information & communication | 2026 |
| RL Durrant Ltd | Construction | 2016 |
| RLW Engineering Ltd | Manufacturing | 2016 |
| RM Wind Services Ltd | Manufacturing | 2025 |
| Roastrunner Ltd | Hospitality | 2021 |
| Roca Technical Services Limited | Professional & scientific | 2007 |
| Ross Mason Surveys Limited | Professional & scientific | 2018 |
| Rowlands AG Services Limited | Agriculture & fishing | 2023 |
| RS Keys Limited | Wholesale & retail | 2025 |