| SLL Accounting Ltd | Professional & scientific | 2019 |
| Sloanes Bespoke Hair LLP | | 2010 |
| Sloanes for Hair Limited | Other services | 2010 |
| SMA Retail Limited | Wholesale & retail | 2023 |
| Small Accounting Services Limited | Professional & scientific | 1998 |
| Smallbrook Views (Warminster) Management Company Limited | Households | 2015 |
| Smals Dredging UK Ltd | Construction | 2015 |
| Smart Choice Home Solutions Limited | Administrative & support | 2024 |
| Smart Colours Limited | Wholesale & retail | 2009 |
| Smart Directing Ltd | Professional & scientific | 2021 |
| Smart Fibre Solutions Limited | Information & communication | 2022 |
| Smart H Interiors Ltd | Manufacturing | 2023 |
| Smart Land Management & Ecology Limited | Professional & scientific | 2024 |
| Smart Pressure Washing Ltd | Administrative & support | 2025 |
| Smart Repar SG Ltd | Wholesale & retail | 2016 |
| Smart Rivers Conservation Limited | Extraterritorial | 2026 |
| Smart Watch Technology Ltd | Extraterritorial | 2023 |
| Smartfix Roofing & Property Maintenance Ltd | Construction | 2025 |
| Smartman Solutions Ltd | Professional & scientific | 2022 |
| Smartstart Motor Solutions Ltd | Wholesale & retail | 2025 |
| Smashing Stack Ltd | Hospitality | 2025 |
| SMD Locations Limited | Arts & recreation | 2023 |
| Smile Creation Properties Limited | Real estate | 2023 |
| Smile Creation UK Limited | Administrative & support | 2008 |
| Smile Implant Centre Ltd | Health & social care | 2012 |
| Smilewhites Limited | Health & social care | 2006 |
| Smiling Door Limited | Real estate | 2025 |
| Smith & PAZ Limited | Hospitality | 2026 |
| Smith FAM Ltd | Wholesale & retail | 2015 |
| Smith Heritage Home Surveys Ltd | Real estate | 2021 |
| Smith Heritage Property Limited | Real estate | 2024 |
| Smith Heritage Surveyors Ltd | Real estate | 2020 |
| Smith's Security Ltd | Administrative & support | 2026 |
| Smithoak Limited | Other services | 2025 |
| Smrt Commerce Ltd. | Wholesale & retail | 2023 |
| SMS Safety Consulting Ltd | Professional & scientific | 2025 |
| Snailwax Limited | Information & communication | 2014 |
| Snow Rose (UK) Limited | Real estate | 2010 |
| Softseries Limited | Information & communication | 2025 |
| Software Innovators Ltd | Information & communication | 2016 |
| Sofy Transport Ltd | Transport & logistics | 2019 |
| SOG Gyle Limited | Administrative & support | 2023 |
| SOG Thetford Limited | Administrative & support | 2023 |
| Soket Construction Ltd | Construction | 2019 |
| Solaplan Limited | Construction | 2022 |
| Solar Park Cleaning Limited | Administrative & support | 2015 |
| Solar Vision Ltd | Construction | 2024 |
| Sole Obsession Limited | Wholesale & retail | 2003 |
| Solent 8658 Ltd | Professional & scientific | 2024 |
| Solent Laptops Limited | Wholesale & retail | 2008 |
| Solent Seafood Limited | Agriculture & fishing | 2017 |
| Solid Concepts Limited | Other services | 1999 |
| Solihull (Lambscote Close) Residents Association Limited | Households | 1985 |
| Solis Direct Ltd. | Wholesale & retail | 2025 |
| Soller Five Limited | Construction | 2017 |
| Solpearl Limited | Health & social care | 2025 |
| Solstice Construction Ltd | Construction | 2013 |
| Solstice Consultancy Services Limited | Professional & scientific | 2007 |
| Solstice Leisure Limited | Wholesale & retail | 1998 |
| Solstice Roofing Services Ltd | Construction | 2024 |
| Solstice Travel Limited | Extraterritorial | 2020 |
| Somerbrook Management Company Limited | Households | 2020 |
| Somerset Gelato Limited | Extraterritorial | 2018 |
| Somerset Teeth Ltd | Health & social care | 2021 |
| Something Beginning With Music Limited | Information & communication | 2007 |
| Somich Ltd | Professional & scientific | 2021 |
| Sommerpath Limited | Administrative & support | 2020 |
| Somnio Games Ltd | Wholesale & retail | 2020 |
| Sonia Odonnell Limited | Extraterritorial | 2025 |
| Sonora Two Management Limited | Households | 2013 |
| Sooriyan Ltd | Wholesale & retail | 2019 |
| Sooth Consulting Limited | Professional & scientific | 2022 |
| Soper & Co Mortgage Brokers Ltd | Financial services | 2023 |
| Sophia Development Partners Limited | Hospitality | 2018 |
| Sorelle Vitality Ltd | Education | 2023 |
| Soterios Limited | Professional & scientific | 2017 |
| Sotunde & Co Limited | Information & communication | 2016 |
| Souchez Gardens Management Company Limited | Households | 2017 |
| Soul and Style Limited | Professional & scientific | 2013 |
| Souledsnitch Ltd | Wholesale & retail | 2026 |
| Soulstice Aesthetics Limited | Health & social care | 2026 |
| Sound R F Ltd | Professional & scientific | 2006 |
| Sound Understanding Limited | Information & communication | 2017 |
| Sounder Live Limited | Information & communication | 2020 |
| Soundright Media Training and Consultancy Limited | Professional & scientific | 2006 |
| Sourcingfocus Ltd | Professional & scientific | 2019 |
| South Coast Building Consultancy Limited | Professional & scientific | 2024 |
| South Coast Cleaning & Maintenance Ltd | Other services | 2019 |
| South Coast Heating Solutions Limited | Construction | 2025 |
| South Coast Loft Insulation & Boarding Limited | Construction | 2024 |
| South Coast Loft Insulation @ Boarding Ltd | Construction | 2026 |
| South Coast Pest Control Ltd | Administrative & support | 2012 |
| South Coast Powersports Ltd | Wholesale & retail | 2023 |
| South Coast Ventures Limited | Construction | 2007 |
| South East EYE Surgeons LLP | | 2007 |
| South Hills School Limited | Education | 2000 |
| South Mill Holidays Limited | Hospitality | 2024 |
| South Mill Road (Amesbury) Limited | Real estate | 2005 |
| South Portway Management Limited | Real estate | 1988 |
| South Property Services Limited | Construction | 2017 |