| Shergill Orthopaedics Limited | Health & social care | 2010 |
| Sheridan White Ltd | Wholesale & retail | 2018 |
| Sherlock Homes & Sons Ltd | Real estate | 2017 |
| Sherrington Consulting Ltd | Professional & scientific | 2023 |
| Shield Partnership Ltd | Financial services | 2019 |
| Shift Wellness Limited | Other services | 2014 |
| Shiftup Events Limited | Administrative & support | 2026 |
| Shining Stars Tutoring Limited | Education | 2023 |
| Shirley Allum Limited | Wholesale & retail | 1996 |
| SHOOT2SURVIVE Ltd | Arts & recreation | 2025 |
| Shopwyke Lakes (Chichester) Management Company Limited | Households | 2016 |
| Shore Deck Marine Ltd | Construction | 2015 |
| Shoreline Solutions Limited | Professional & scientific | 2025 |
| Showell Nurseries Management Company Limited | Households | 2025 |
| Shree Matangi Enterprise Ltd | Wholesale & retail | 2025 |
| Shrewton Drive Management Company Limited | Households | 2013 |
| Shrewton Laundry Ltd | Administrative & support | 2020 |
| Shri Mirambica Ltd | Real estate | 2019 |
| Shropshire Management Company Limited | Real estate | 1991 |
| Shub Estate UK Ltd | Real estate | 2025 |
| Shukra Software Ltd | Information & communication | 2024 |
| Shurmer Developments Limited | Construction | 2002 |
| Shutter Specialists Ltd | Extraterritorial | 2015 |
| Sialia Consultants Ltd | Professional & scientific | 2017 |
| Sibor Limited | Professional & scientific | 2010 |
| Sicily Care Limited | Health & social care | 2025 |
| SID Phiri Priority Care Limited | Health & social care | 2015 |
| Sidian Ltd | Construction | 2023 |
| Sidonie Developments Limited | Construction | 2023 |
| Sieben Global Management Limited | Professional & scientific | 2017 |
| Signature HI Ltd | Construction | 2019 |
| Signature Protection Ltd | Administrative & support | 2018 |
| Signly Limited | Information & communication | 2017 |
| Signs in Motion Limited | Manufacturing | 2000 |
| Silicondust UK Limited | Manufacturing | 2014 |
| Silk Services Limited | Construction | 2016 |
| Silk Storage Limited | Transport & logistics | 2025 |
| Silver Sunshine Ltd | Wholesale & retail | 2018 |
| Silver Wings Film Limited | Information & communication | 2018 |
| Silvermead Court Management Limited | Households | 2019 |
| Simba's Pride Ltd | Professional & scientific | 2025 |
| Simon House Electrical Services Limited | Construction | 2010 |
| Simon Jackson Contractors Limited | Agriculture & fishing | 2003 |
| Simon Tubb Painter & Decorator Limited | Construction | 2003 |
| Simparr Consulting Ltd | Information & communication | 2014 |
| Simplispotless Ltd | Manufacturing | 2026 |
| Simply Good Food Ltd | Hospitality | 2021 |
| Simply Olives & Nuts Ltd | Wholesale & retail | 2023 |
| Simply Site Supplies Limited | Wholesale & retail | 2024 |
| Simply Untouched Ltd | Wholesale & retail | 2013 |
| Simplyfarquharsphotography Limited | Professional & scientific | 2017 |
| Simpson Retail Consulting Ltd | Information & communication | 2011 |
| Sims Catering Salisbury Limited | Hospitality | 2016 |
| Sing to Heal Ltd | Health & social care | 2023 |
| Singh and Swift Ambala Limited | Hospitality | 2026 |
| Singh Kitchen and Bedroom Limited | Construction | 2018 |
| SIP and Smile Ltd | Wholesale & retail | 2022 |
| SIP Circle Ltd | Wholesale & retail | 2021 |
| Sirach Ltd | Hospitality | 2023 |
| Sircleuk Ltd | Extraterritorial | 2021 |
| Siri Panyo Ltd | Wholesale & retail | 2025 |
| Siteform Trucks Limited | Transport & logistics | 2011 |
| SIX BAD Poets Limited | Arts & recreation | 2024 |
| SIX Sigma Investments Ltd | Real estate | 2019 |
| SIX Week Summer Limited | Wholesale & retail | 2025 |
| Sixpenny Forge Limited | Manufacturing | 2017 |
| Sixpenny Transport Ltd | Transport & logistics | 2026 |
| Sixty Second Golf Ltd | Information & communication | 2021 |
| Sizzling Kick Ltd | Professional & scientific | 2019 |
| SJG Aero Ltd | Professional & scientific | 2019 |
| SJH Vascular Ltd | Health & social care | 2023 |
| SJK Scientifics Limited | Administrative & support | 1987 |
| SJP Rental Properties UK Ltd | Real estate | 2024 |
| SJP Tableware Limited | Administrative & support | 2012 |
| SK Barbers Ltd | Other services | 2019 |
| SK Electrical Engineers Limited | Administrative & support | 2013 |
| SK Fenix Group Limited | Administrative & support | 2026 |
| SK Property Maintenance (Southern) Limited | Construction | 2023 |
| Skellow Management Company Limited | Households | 2006 |
| SKI Boutique Limited | Hospitality | 2019 |
| Skin Bliss Studio Limited | Wholesale & retail | 2023 |
| Skin Rehab Ltd | Health & social care | 2024 |
| Skinners Union Clothing Company Limited | Extraterritorial | 2020 |
| Skinners Union Trading Company Limited | Extraterritorial | 1999 |
| Skndp Limited | Real estate | 2022 |
| Skookum Management Limited | Real estate | 2016 |
| Sky Guardian Systems Ltd | Information & communication | 2025 |
| Sky Plaza (Farnborough) Management Company Limited | Households | 2021 |
| Sky Sports Rigging Limited | Manufacturing | 2013 |
| Skycircuits Ltd | Manufacturing | 2008 |
| Skydive (Headcorn) Limited | Arts & recreation | 2011 |
| Skydive Southcoast Limited | Extraterritorial | 2008 |
| Skydive Swansea Club Ltd | Arts & recreation | 2014 |
| Skydive Swansea Ltd | Arts & recreation | 2008 |
| Skyebrooke Solutions Ltd | Professional & scientific | 2023 |
| Skylark View (Highworth) Management Company Limited | Households | 2024 |
| Slaters Roofing & Leadwork Ltd | Construction | 2017 |
| Slbd Enterprises Limited | Information & communication | 2025 |
| SLC Holding South Limited | Financial services | 2024 |
| Sleep Mastery Ltd | Other services | 1998 |