| Schooner Wharf Management Company Limited | Households | 1996 |
| Scolvale Limited | Households | 1973 |
| Scots Lane Property Limited | Real estate | 2016 |
| Scott & Browns Hotel Ltd | Hospitality | 2021 |
| Scout Group Ltd | Information & communication | 2025 |
| SCP Construction Ltd | Construction | 2020 |
| Scrace Architects Ltd | Professional & scientific | 2018 |
| Screedy Does IT Ltd | Construction | 2023 |
| SD Morton Media Ltd | Professional & scientific | 2022 |
| SDA Cleaning Ltd | Administrative & support | 2017 |
| Sdbf Building Consultancy Limited | Construction | 2017 |
| SDC Trustee Limited | Financial services | 2025 |
| SDH Crisis Management Limited | Professional & scientific | 2024 |
| SE Hair Limited | Other services | 2026 |
| Sea Sense Mortgages Limited | Financial services | 2003 |
| Sea Shell Productions Limited | Information & communication | 1999 |
| Seahorse Consultancy Solutions Ltd | Information & communication | 2011 |
| Sealion Ltd | Wholesale & retail | 2017 |
| Sean Brocksom Limited | Construction | 2013 |
| Sean White Roofing Limited | Construction | 2019 |
| Search 4 Search Limited | Administrative & support | 2014 |
| Search Recruitment Limited | Administrative & support | 1995 |
| Seascape (Ilfracombe) Management Company Limited | Households | 2023 |
| Seasons of East Ltd | Wholesale & retail | 2017 |
| Seaview Apartments (Machynys) Management Company Limited | Households | 2013 |
| SEB Tours and Transfers Limited | Administrative & support | 2025 |
| Security and Defence Services Limited | Professional & scientific | 2012 |
| Security Bollards Direct Ltd | Construction | 2022 |
| Security Depots Ltd | Administrative & support | 2016 |
| Security Management Installations Limited | Construction | 2014 |
| Security Sales Ltd | Wholesale & retail | 2002 |
| Securivin Limited | Construction | 2000 |
| Sedef Catering Ltd | Hospitality | 2021 |
| Sedicii Limited | Information & communication | 2013 |
| Sedum Green Roof Ltd | Agriculture & fishing | 2010 |
| SEE Space Differently CIC | Professional & scientific | 2025 |
| Seed Intelligence Limited | Information & communication | 2018 |
| Seend Management Company Limited | Professional & scientific | 2001 |
| Sehume M.P Ltd | Health & social care | 2018 |
| Selcuk Architecture Limited | Professional & scientific | 2021 |
| Select Europe (UK) Ltd | Wholesale & retail | 2022 |
| Select Mirrors Ltd | Wholesale & retail | 2023 |
| Seling Property Investment Ltd | Real estate | 2023 |
| Selmech Supplies Limited | Manufacturing | 2004 |
| Selver Limited | Wholesale & retail | 2024 |
| Selwyn Events Limited | Administrative & support | 2024 |
| Semacs Catering Limited | Hospitality | 2018 |
| Semley Lantrac 4X4 Limited | Wholesale & retail | 2002 |
| Semper Agnitio Limited | Professional & scientific | 2014 |
| SEO Breakthrough Ltd | Information & communication | 2014 |
| Seodrap LLP | | 2013 |
| Sephrin Developments Limited | Construction | 2003 |
| Septagrama Limited | Manufacturing | 2022 |
| Sequitur Ltd | Information & communication | 2015 |
| Seraph Crystals Ltd | Wholesale & retail | 2022 |
| Serene Abode Realty Limited | Real estate | 2022 |
| Serene Healthcare Group Ltd | Health & social care | 2020 |
| Serenity Estates Limited | Real estate | 2006 |
| Serious Shooting Limited | Arts & recreation | 2004 |
| SET 3 Ltd | Professional & scientific | 2012 |
| Sett Publishing Limited | Information & communication | 2024 |
| Sevaen Consulting Limited | Information & communication | 2014 |
| Seven Acres (Elford) Management Company Limited | Households | 2022 |
| Seven Acres Dog Field Ltd | Arts & recreation | 2025 |
| Seven Tenths Ecology Ltd | Professional & scientific | 2014 |
| Severells Fields (Siddington) Management Company Limited | Households | 2021 |
| Seymoor Land Securities Limited | Real estate | 1973 |
| Seymour Gardens Amesbury Management Company Limited | Households | 2013 |
| Seymour Place (Mangotsfield) Management Company Limited | Households | 2008 |
| Sfmx Ltd | Financial services | 2024 |
| SFR Design Ltd | Arts & recreation | 2024 |
| SGS Asia Ltd | Manufacturing | 2024 |
| SGS Building Services Ltd | Construction | 2020 |
| SH Waterproofing Solutions Limited | Construction | 2021 |
| Shabab's Assets Ltd | Real estate | 2025 |
| Shabab-Zain Transportation Ltd | Transport & logistics | 2022 |
| Shadlock Associates Limited | Professional & scientific | 2010 |
| Shadow Holdr Ltd | Professional & scientific | 2015 |
| Shadow UK Construction Limited | Construction | 2022 |
| Shaftesbury Park Chambers Management Company Limited | Households | 2005 |
| Shalom Logistics&General Suppliers Ltd | Transport & logistics | 2016 |
| Shamaya Limited | Real estate | 2021 |
| Shamrock Works Limited | Wholesale & retail | 1997 |
| Shanti Holdings Limited | Financial services | 2023 |
| Shanty Productions Limited | Information & communication | 2015 |
| Shape Contractor Limited | Construction | 2013 |
| Share Salisbury (a Library of Things) CIC | Administrative & support | 2021 |
| Sharelink Group Ltd | Information & communication | 2020 |
| Shark Logistics Group Ltd | Transport & logistics | 2021 |
| Shark Logistics Ltd | Transport & logistics | 2020 |
| Sharlyn Property Limited | Administrative & support | 2005 |
| Sharon Hawkes Willcare Ltd | Other services | 2026 |
| Shaston Court (Wilton) Management Company Limited | Real estate | 2002 |
| Shawqat Worldwide Limited | Information & communication | 2013 |
| Shearwater Virtual Assistance Limited | Extraterritorial | 2022 |
| Sheekey Science Solutions Limited | Professional & scientific | 2021 |
| Sheila Mckechnie Trading Ltd | Professional & scientific | 2021 |
| Sheldons Reach (Hook) Management Company Limited | Households | 2017 |
| Shepherds Fold (Mickleton) Management Company Limited | Households | 2015 |
| Sheppard & Co Limited | Professional & scientific | 2012 |