| SK Imports & Wholesale (UK) Ltd | Wholesale & retail | 2012 |
| SK Patel Traders Ltd | Wholesale & retail | 2025 |
| SK Property Relocation Limited | Extraterritorial | 2024 |
| SK Rope Access Ltd | Manufacturing | 2026 |
| Skechly Limited | Financial services | 2021 |
| Skeffco Ltd | Real estate | 2021 |
| Skegness Raceway Ltd | Arts & recreation | 2016 |
| Skelmersdale Nominees Ltd | Extraterritorial | 2021 |
| Skiillo Limited | Health & social care | 2025 |
| Skill Mind Ltd | Professional & scientific | 2023 |
| Skillisle Ltd | Information & communication | 2026 |
| SKILLS2THRIVE Ltd | Education | 2022 |
| Skillsfit CIC | Education | 2025 |
| Skillsfit Training and Education Ltd | Education | 2025 |
| Skin Bar Ltd | Other services | 2018 |
| Skin of Interest Ltd | Wholesale & retail | 2022 |
| Skinworx Training Academy Ltd | Other services | 2018 |
| Skip Hire Near ME Limited | Extraterritorial | 2018 |
| SKKOMPANY2022 Ltd | Wholesale & retail | 2022 |
| SKO Signalling Ltd | Construction | 2019 |
| SKT Wholesale Ltd | Wholesale & retail | 2025 |
| Skvermcr Ltd | Other services | 2022 |
| Sky Bison Properties Limited | Real estate | 2024 |
| Sky Eagles EGY Group Limited | Wholesale & retail | 2024 |
| Sky Rise Investments Ltd | Real estate | 2007 |
| Sky Shine Limited | Wholesale & retail | 2023 |
| Skycap Limited | Real estate | 2017 |
| Skycare Recruitment Limited | Health & social care | 2014 |
| Skycommsuk Limited | Information & communication | 2013 |
| Skye Edge SPV Limited | Real estate | 2017 |
| Skyhawk Estates Limited | Other services | 2021 |
| Skyhawk Holdings Limited | Other services | 2021 |
| Skyscope Limited | Education | 1989 |
| Skytex (UK) Limited | Wholesale & retail | 2013 |
| SL1 Ltd | Health & social care | 2018 |
| SLA Estates Ltd | Real estate | 2025 |
| Slatemont Limited | Real estate | 1988 |
| Sleek Solutions Ltd | Wholesale & retail | 2021 |
| Slejem Properties Limited | Real estate | 2019 |
| SLH Commercial Ltd | Financial services | 2022 |
| SLH Property Holdings Ltd | Real estate | 2023 |
| Sliiip Media Ltd | Information & communication | 2021 |
| SLK Manchester Limited | Wholesale & retail | 2018 |
| Sloegrin Limited | Wholesale & retail | 2000 |
| Slough Breakdown Recovery Ltd | Transport & logistics | 2025 |
| Slowboat HD Limited | Hospitality | 2026 |
| Sloyan Trading Ltd | Professional & scientific | 2026 |
| SM Lyallpur Properties Limited | Real estate | 2025 |
| SM Mobile Auto Electrician Ltd | Wholesale & retail | 2026 |
| Smab Property Investments Ltd | Real estate | 2020 |
| Small Family Car Limited | Wholesale & retail | 2012 |
| Small Flats UK Ltd | Real estate | 2026 |
| Smallify Limited | Professional & scientific | 2025 |
| Smallscripts Ltd | Professional & scientific | 2022 |
| Smart Builder Solution Ltd | Construction | 2022 |
| Smart Builderman Ltd | Construction | 2023 |
| Smart Dispute Resolution Limited | Professional & scientific | 2025 |
| Smart Driver Club Ltd | Education | 2024 |
| Smart Drylining Solution Ltd | Construction | 2019 |
| Smart Living Supplies Ltd | Wholesale & retail | 2025 |
| Smart Site Solutions Ltd | Professional & scientific | 2016 |
| Smartbuyuk Ltd | Wholesale & retail | 2025 |
| Smarter Home 4U Limited | Construction | 2013 |
| Smarties and Smartcare Limited | Education | 1996 |
| Smartsched Limited | Information & communication | 2025 |
| Smashdraws Ltd | Administrative & support | 2025 |
| Smashed Group Ltd | Hospitality | 2026 |
| SMC Healthcare Ltd | Real estate | 2022 |
| SMD UK Estates Limited | Real estate | 2024 |
| SMD UK Management Limited | Financial services | 2023 |
| Smej Ltd | Administrative & support | 2025 |
| Smepac Pharma Consulting Ltd | Professional & scientific | 2025 |
| SMH Capital Ltd | Real estate | 2025 |
| SMH Protection Services Limited | Administrative & support | 2024 |
| Smhk Limited | Hospitality | 2026 |
| Smile & BE Happy Limited | Wholesale & retail | 2017 |
| Smile Distribution Ltd | Wholesale & retail | 2026 |
| Smiler Sugarplum Holdings Ltd | Health & social care | 2025 |
| Smiling Herbs Ltd | Wholesale & retail | 2024 |
| Smiling Kidz Ltd | Health & social care | 2026 |
| Smiths Blinds Ltd | Manufacturing | 2007 |
| Smithstone Properties Ltd | Construction | 2025 |
| Smithy Mews Nominees 2 Ltd | Extraterritorial | 2021 |
| Smithy Mews Nominees Ltd | Extraterritorial | 2021 |
| Smoke House Manchester Ltd | Manufacturing | 2025 |
| Smoke House MCR Ltd | Manufacturing | 2025 |
| Smokestack Software Ltd | Information & communication | 2013 |
| SMP Management Services Ltd | Information & communication | 2006 |
| SMR Autowerks Ltd | Wholesale & retail | 2017 |
| SMS & Sons Ltd | Wholesale & retail | 2014 |
| SMS Pharmacy Ltd | Health & social care | 2010 |
| SMV Roofing Ltd | Construction | 2025 |
| SMX Beauty and Care Ltd | Health & social care | 2021 |
| SN Business Services Ltd | Professional & scientific | 2004 |
| SNA Consultancy Ltd | Education | 2024 |
| SNA Retail Ltd | Wholesale & retail | 2026 |
| Snackable Media Ltd | Professional & scientific | 2026 |
| Snackisfied Ltd | Hospitality | 2025 |
| Snackruptors Holdco Limited | Other services | 2018 |
| Snackruptors Limited | Wholesale & retail | 1994 |