| Shoalter Automation (UK) One Limited | Administrative & support | 2023 |
| Shoalter Automation (UK) Three Limited | Real estate | 2024 |
| Shoalter Automation (UK) Two Limited | Real estate | 2023 |
| Shoe Storee Limited | Wholesale & retail | 2021 |
| Shoku Bunka MCR Ltd | Hospitality | 2019 |
| Shop From Home Ltd | Wholesale & retail | 2026 |
| Shop Inaba Ltd | Wholesale & retail | 2025 |
| SHOPPING4EASY Ltd | Wholesale & retail | 2021 |
| Shopverseuk Limited | Wholesale & retail | 2025 |
| Shortrose Developments Limited | Real estate | 2005 |
| Shotayo Ltd | Health & social care | 2023 |
| SHP Property Investments Ltd | Real estate | 2014 |
| Shpitz Refurbishments Ltd | Construction | 2021 |
| SHS Property Investments Limited | Real estate | 2013 |
| Shugi Traders Ltd | Wholesale & retail | 2019 |
| Shutfim Ltd | Real estate | 2020 |
| Shutter Affairs Production Ltd | Information & communication | 2025 |
| Shuumba Limited | Health & social care | 2022 |
| Shvilim Ltd | Health & social care | 2025 |
| SHY Estates Ltd | Real estate | 2025 |
| Shyhigh Ltd | Real estate | 2025 |
| SI Prestige Builders Limited | Construction | 2023 |
| SIA Appliances Limited | Wholesale & retail | 2012 |
| Side by Side: Creative Minds CIC | Education | 2026 |
| Sidhu's Services Ltd | Transport & logistics | 2019 |
| Sidings Court Ltd | Real estate | 2026 |
| Siema Limited | Administrative & support | 2013 |
| Sierra's R US NW Ltd | Wholesale & retail | 2018 |
| Sightseeing Experiences Ltd | Administrative & support | 2025 |
| Sigma Gaia Investments Limited | Financial services | 2026 |
| Sigma Nomos Real Estate Limited | Professional & scientific | 2023 |
| Sigma Rectrix Systems (UK) Limited | Hospitality | 2018 |
| Signal Pulse Media Ltd | Information & communication | 2025 |
| Signature Ventures Ltd | Wholesale & retail | 2019 |
| SIL Compliance Ltd | Professional & scientific | 2026 |
| Silentchairubu CIC | Education | 2025 |
| Siloy UK & Ireland Ltd | Professional & scientific | 2025 |
| Silva Essence Ltd | Wholesale & retail | 2026 |
| Silver Spoon Salford II Limited | Real estate | 2017 |
| Silver Spoon Salford Limited | Real estate | 2017 |
| Silver Traders Ltd | Wholesale & retail | 2012 |
| Silver Ventures Limited | Other services | 2019 |
| Silverbrook Cleaning Solutions Ltd | Administrative & support | 2026 |
| Silverdale Apartment 2 Ltd | Extraterritorial | 2019 |
| Silverdale Apartment Ltd | Extraterritorial | 2019 |
| Silverdale Brick Ltd | Extraterritorial | 2019 |
| Silverdale Brick NO 2 Ltd | Extraterritorial | 2019 |
| Silverdale Third Ltd | Extraterritorial | 2019 |
| Silverdale Third NO 2 Ltd | Extraterritorial | 2019 |
| Silverdove Limited | Real estate | 2015 |
| Silvermantle NO. 2 Limited | Extraterritorial | 2017 |
| Silverwell Estate Company Limited | Real estate | 2017 |
| Silverwood Real Estates Ltd | Construction | 2024 |
| Silverworld (MCR) Ltd | Extraterritorial | 2011 |
| SIM Commercial Estates Ltd | Real estate | 2024 |
| SIM Property Investments Ltd | Real estate | 2020 |
| SIM Services Limited | Real estate | 2019 |
| SIM Tetlow Estates Ltd | Real estate | 2022 |
| SIM Trade Ltd | Construction | 2023 |
| Simatell Limited | Extraterritorial | 2016 |
| Simcha Day Care | Health & social care | 2025 |
| Simcha Delights Ltd | Manufacturing | 2019 |
| Simen TOV Ltd | Real estate | 2022 |
| Simgold Estates Ltd | Real estate | 2023 |
| Simon TOV Estates Limited | Real estate | 2015 |
| Simple Air Solutions Ltd | Construction | 2016 |
| Simple Bricks Property Group Ltd | Real estate | 2025 |
| Simple Deals UK Ltd | Wholesale & retail | 2022 |
| Simple Swift Property Ltd. | Real estate | 2021 |
| Simplex Officia Limited | Administrative & support | 2023 |
| Simplifly Travel Ltd | Administrative & support | 2025 |
| Simplify Holdings Limited | Administrative & support | 2016 |
| Simply Build Solutions NW Ltd | Construction | 2024 |
| Simply Toys Ltd | Wholesale & retail | 2010 |
| Simply Vape (Whitefield) Limited | Wholesale & retail | 2017 |
| Sina Honarvar Limited | Professional & scientific | 2025 |
| Sinclair Grove Legal Limited | Financial services | 2020 |
| Sinderland Limited | Extraterritorial | 1998 |
| Sing Sing Jewellery Limited | Wholesale & retail | 2024 |
| Singhs Grillhouse Ltd | Administrative & support | 2017 |
| Single Homeless Action Initiative in Durham Limited | Hospitality | 1998 |
| Singleton Court Management Company Limited | Households | 1975 |
| Singleton IT Limited | Information & communication | 2016 |
| Singleton Lodge (Broughton Park) Limited | Hospitality | 2010 |
| Singleton Lodge Limited | Real estate | 2003 |
| Singleton Point Management Ltd | Real estate | 2014 |
| Singline Limited | Education | 2003 |
| Sisi Clinic Ltd | Other services | 2023 |
| Site Clearance, Transport & Logistics Ltd | Transport & logistics | 2024 |
| Sixth House Theatre Ltd | Arts & recreation | 2024 |
| Siyata Dishmaya Estates Limited | Real estate | 2026 |
| SJ Coatings Ltd | Construction | 2022 |
| SJ Compliance Ltd | Professional & scientific | 2022 |
| SJH25 Group Ltd | Wholesale & retail | 2025 |
| SJP Staple Management Company Limited | Households | 2022 |
| SK Agga Investments Ltd | Real estate | 2022 |
| SK Barbers MCR Ltd | Other services | 2023 |
| SK Curry House Ltd | Hospitality | 2024 |
| SK Fashion NW Ltd | Manufacturing | 2019 |
| SK Gladstone Ltd | Real estate | 2026 |