| Serenity Apartments Ltd | Real estate | 2025 |
| Serenity MCR Limited | Other services | 2022 |
| Serious Law Investments Limited | Financial services | 2022 |
| Serotonin Suites Limited | Real estate | 2025 |
| Service and Story Ltd | Professional & scientific | 2026 |
| Service Property Investment Ltd | Extraterritorial | 2019 |
| Service Supply Ltd | Other services | 2025 |
| SERVICE24H Ltd | Administrative & support | 2023 |
| Sesa Investments and Services Ltd | Real estate | 2024 |
| SET Sail Ministries Limited | Arts & recreation | 2015 |
| Settle Greental Investments Ltd | Real estate | 2022 |
| Seven Arches Ltd | Real estate | 2021 |
| Seven Brothers Ancoats Ltd | Manufacturing | 2015 |
| Seven Brothers Brewery Limited | Manufacturing | 2013 |
| Seven Brothers Distilling Limited | Manufacturing | 2023 |
| Seven Brothers Holdings Limited | Financial services | 2025 |
| Seven Brothers Kampus Ltd | Hospitality | 2023 |
| Seven Brothers Leeds Limited | Hospitality | 2020 |
| Seven Brothers London Limited | Hospitality | 2020 |
| Seven Heights Ltd | Real estate | 2025 |
| Sevenoaks Challenger Ltd | Extraterritorial | 2022 |
| Seventhreeone | Public administration | 2015 |
| Seventrading Ltd | Wholesale & retail | 2023 |
| Sewana Hot Food Ltd | Hospitality | 2026 |
| SF Audio Limited | Information & communication | 2024 |
| SFG Innovations Limited | Manufacturing | 2017 |
| SFI Trading Limited | Wholesale & retail | 2025 |
| SGK Legal Limited | Professional & scientific | 2022 |
| SH Aviation Services Limited | Professional & scientific | 2025 |
| SH Planning Law Limited | Professional & scientific | 2021 |
| Shaar Shomayim Limited | Real estate | 2021 |
| Shaarei Shamayim Synagogue Ltd | Other services | 2025 |
| Shad Homes Limited | Construction | 2021 |
| Shad Salon Ltd | Other services | 2022 |
| Shade Hair MCR Ltd | Other services | 2021 |
| Shadluf Ltd | Real estate | 2014 |
| Shafqat Property Group Limited | Construction | 2024 |
| Shahbarose Ltd | Hospitality | 2018 |
| Shaheen Enterprise Limited | Real estate | 2019 |
| Shaindys Studio Ltd | Other services | 2017 |
| Shakes Box Ltd | Hospitality | 2026 |
| Shaliville Ltd | Extraterritorial | 2008 |
| Shaltal Limited | Professional & scientific | 2023 |
| Sham Palaces Ltd | Hospitality | 2026 |
| Shamford Ltd | Real estate | 2018 |
| Shami-Uk Limited | Wholesale & retail | 2020 |
| Shanel Estates Limited | Real estate | 2024 |
| Shanghai MET IMP & EXP Co Ltd | Arts & recreation | 2024 |
| Shanklin Estates Limited | Extraterritorial | 2020 |
| Shared Ambition Support Ltd | Construction | 2022 |
| Shared Ambitions Ltd | Financial services | 2024 |
| Sharp Builders Ltd | Construction | 2025 |
| Sharp Solutionz Limited | Wholesale & retail | 2023 |
| Shas Olami UK | Public administration | 2023 |
| Shaw Retail Estates Limited | Other services | 2022 |
| Shawco Estates Limited | Real estate | 2021 |
| Shayas Associates Limited | Hospitality | 2023 |
| Sheba Arts CIC | Arts & recreation | 2020 |
| Shedd Real Estate Limited | Real estate | 2022 |
| Sheegoon Limited | Administrative & support | 2020 |
| Shefa Brocha 1 Ltd | Real estate | 2024 |
| Shefa Brocha Limited | Real estate | 2009 |
| Shefa Grow Ltd | Real estate | 2024 |
| Shefa Line Limited | Wholesale & retail | 2015 |
| Shefa Live Ltd | Real estate | 2025 |
| Sheffield Local Television Ltd | Information & communication | 2012 |
| Sheila's Family Stores Limited | Wholesale & retail | 2021 |
| Shelgo LLP | | 2018 |
| Shelley's Shorties Limited | Health & social care | 2023 |
| Shepherdfoot Ltd | Health & social care | 2026 |
| Shepherds Digital Ltd | Wholesale & retail | 2025 |
| Sherdan Limited | Real estate | 2025 |
| Shewa Hot Food Ltd | Hospitality | 2023 |
| Shezab Mediaworx Ltd | Information & communication | 2025 |
| Shezab Stores Ltd | Wholesale & retail | 2025 |
| Shguk Limited | Real estate | 2023 |
| Shield Enterprises Limited | Real estate | 2020 |
| Shieldguard Solutions Limited | Administrative & support | 2023 |
| Shiffyton Ltd | Extraterritorial | 2003 |
| Shift Project Management Limited | Professional & scientific | 2024 |
| Shilbeat Limited | | 1977 |
| Shill's Limited | Wholesale & retail | 2009 |
| Shillingtown Ltd | Extraterritorial | 2004 |
| Shimz Ltd | Professional & scientific | 2021 |
| Shine Dental Laboratory Ltd | Health & social care | 2018 |
| Shine Interview Limited | Information & communication | 2010 |
| Shinghar Ltd | Wholesale & retail | 2022 |
| Shining Star (UK) Limited | Wholesale & retail | 2008 |
| Shining Stars (NW) Limited | Health & social care | 2025 |
| Ship IT Appliances Limited | Wholesale & retail | 2011 |
| Shiradale Ltd | Extraterritorial | 2003 |
| Shiral Ltd | Real estate | 2022 |
| Shirebrick Ltd | Extraterritorial | 2012 |
| Shirland Investments Ltd | Real estate | 2026 |
| Shitfus Ltd | Real estate | 2020 |
| Shivam Minerals UK Ltd | Mining & quarrying | 2024 |
| Shlish Bekarka Limited | Real estate | 2025 |
| Shnw Ltd | Construction | 2024 |
| Shoaibi Ltd | Wholesale & retail | 2025 |
| Shoalter Automation (UK) Limited | Real estate | 2021 |