| SB Property Maintenance Limited | Manufacturing | 2013 |
| Sbai Saida Ltd | Wholesale & retail | 2024 |
| SBB Trade Ltd | Wholesale & retail | 2026 |
| Sbbp Ltd | Real estate | 2020 |
| SBC Investments Ltd | Real estate | 2022 |
| SBF Estates Ltd | Real estate | 2021 |
| SBG Eastbourne Ltd | Real estate | 2024 |
| SBN Private Ltd | Wholesale & retail | 2023 |
| SBS Technologies Limited | Information & communication | 2004 |
| Sbs(Uk) Limited | Wholesale & retail | 2015 |
| SC Eco Cleaning Ltd | Administrative & support | 2022 |
| Scalable Fintech Solutions Limited | Professional & scientific | 2026 |
| Scan Coin Technology Limited | Manufacturing | 1985 |
| Scan ME DLC Ltd | Information & communication | 2025 |
| Scene IT, Sold Ltd | Professional & scientific | 2025 |
| Scharf Capital Ltd | Real estate | 2025 |
| Schawk UK Limited | Administrative & support | 1997 |
| Scherer Holdings Ltd | Real estate | 2026 |
| Schiffshul Manchester Limited | Other services | 2026 |
| Schlesinger Ltd | Real estate | 2024 |
| Schocroft Cove Ltd | Financial services | 2013 |
| Schofield LDF Ltd | Transport & logistics | 2026 |
| School Extensions Ltd | Construction | 2007 |
| School Holding Ltd | Real estate | 2022 |
| School House Nursery (VNG) Limited | Health & social care | 2020 |
| Schultz Pieters OAG Limited | Real estate | 2017 |
| Schvartz Estates Ltd | Real estate | 2022 |
| Schwimmer Properties Ltd | Real estate | 2021 |
| Scicom International (UK) Limited | Administrative & support | 2002 |
| Scideco Art Ltd | Wholesale & retail | 2020 |
| SCL Car Lease Ltd | Administrative & support | 2024 |
| SCL Trading Limited | Hospitality | 2013 |
| Scmd Properties Limited | Real estate | 2023 |
| Scot Green Ltd | Real estate | 2017 |
| Scott Hunter Group Limited | Arts & recreation | 2025 |
| Scott Imports Limited | Wholesale & retail | 2026 |
| Scott Langridge Ltd | Arts & recreation | 2014 |
| Scrap ANY Car Manchester Ltd | Water & waste | 2026 |
| Screenriot Ltd | Information & communication | 2026 |
| Screenthreads Ltd | Administrative & support | 2022 |
| Script Assist Ltd | Wholesale & retail | 2023 |
| Scrn Skin Ltd | Wholesale & retail | 2025 |
| Scrub -a- DUB Cleaning Ltd Ltd | Administrative & support | 2025 |
| SD Itad Ltd | Water & waste | 2019 |
| SD Potts Holdings Limited | Financial services | 2023 |
| SD Worx UK Limited | Administrative & support | 1995 |
| SDG Property Ltd | Real estate | 2026 |
| SDH18 Limited | Real estate | 2022 |
| SDK Bars MCR Ltd | Hospitality | 2025 |
| Seaford Road Limited | Construction | 2018 |
| Seagull Films Limited | Arts & recreation | 1979 |
| Seaham Coop Estates Limited | Other services | 2024 |
| Seaham Estates Holdings Limited | Other services | 2024 |
| Seal Logistics Solutions Limited | Other services | 2020 |
| Seamarque Ltd | Professional & scientific | 2024 |
| Seamless Slay Ltd | Other services | 2025 |
| Seasoned Digital Limited | Information & communication | 2024 |
| SEB Speed Trans Manchester Ltd | Transport & logistics | 2017 |
| Sebor Ltd | Wholesale & retail | 2010 |
| Seby Cris Ltd | Transport & logistics | 2018 |
| Second Chance Arts C.I.C. | Information & communication | 2026 |
| Second Opinion Experts Ltd | Health & social care | 2021 |
| Secret Lookz Ltd | Wholesale & retail | 2014 |
| Secure IT UP Ltd | Construction | 2025 |
| Seddon Towers Ltd | Real estate | 2024 |
| SEEK3R Ltd | Administrative & support | 2025 |
| Seetrix Limited | Manufacturing | 2024 |
| Seforim Mart Limited | Wholesale & retail | 2024 |
| Seiden Estates Ltd | Real estate | 2022 |
| Selby Commercial Counsel Limited | Professional & scientific | 2017 |
| Selcastle Management Company Limited | Households | 1977 |
| Selco Estates Ltd | Real estate | 2020 |
| Select (Appliance Centre) Limited | Wholesale & retail | 1996 |
| Select Artists Limited | Information & communication | 2024 |
| Select Pro Ltd | Construction | 2019 |
| Selection Recruitment Limited | Administrative & support | 2016 |
| Selectiva Ltd | Wholesale & retail | 2024 |
| Selectric Limited | Extraterritorial | 1995 |
| Selectric U.K. Limited | Extraterritorial | 1999 |
| Sellata Limited | Health & social care | 1980 |
| Sellercount Ltd | Professional & scientific | 2021 |
| Selpac Limited | Manufacturing | 2016 |
| Selworthy Close Limited | Real estate | 2025 |
| SEN ZEN CIC | Health & social care | 2024 |
| Send Accounts Ltd | Professional & scientific | 2020 |
| Sensai Records Ltd | Information & communication | 2020 |
| Senselogix Limited | Manufacturing | 2009 |
| Sensitive Compartmented Information Facility UK Limited | Construction | 2021 |
| Sensu Insight Ltd | Professional & scientific | 2022 |
| Sentinel Advisory Group Ltd | Professional & scientific | 2025 |
| Sentinel Ambulance Services Ltd | Health & social care | 2022 |
| Sentinelled Ltd | Transport & logistics | 2020 |
| Senyis Ltd | Real estate | 2021 |
| Seoclamp Limited | Information & communication | 2024 |
| September 13 Global Services Limited | Administrative & support | 2025 |
| September Talent Agency Limited | Professional & scientific | 2022 |
| Septimus Consulting Ltd | Wholesale & retail | 2019 |
| Serendipity Therapy Limited | Health & social care | 2025 |
| Serene Business Solutions Ltd | Administrative & support | 2025 |
| Serene Clean London Ltd | Administrative & support | 2023 |