| Salford Slow Fashion CIC | Education | 2022 |
| Salford Software Limited | Information & communication | 1988 |
| Salford Super Store Limited | Wholesale & retail | 2023 |
| Salford Supermarket MCR Limited | Wholesale & retail | 2024 |
| Salford Supermarket MCR LYD Ltd | Hospitality | 2026 |
| Salford Supply Desk Limited | Administrative & support | 2008 |
| Salford Talmudic Association Ltd | Education | 2012 |
| Salford Tax Specialists Ltd | Professional & scientific | 2017 |
| Salford Textiles (CMT) Ltd | Manufacturing | 2023 |
| Salford Tool Hire Ltd | Administrative & support | 2023 |
| Salford Trampoline Club Ltd | Arts & recreation | 2017 |
| Salford Tyre World Ltd | Wholesale & retail | 2025 |
| Salford University Services Limited | Professional & scientific | 2002 |
| Salford Victoria Theatre Trust | Arts & recreation | 2013 |
| Salford Waste Assets Limited | Professional & scientific | 2008 |
| Salford Waste Management Limited | Extraterritorial | 2003 |
| Salford Wrestling Academy CIC | Arts & recreation | 2022 |
| Salfordian Arts PUB Ltd | Hospitality | 2015 |
| Salix Homes Developments Limited | Construction | 2016 |
| Salix Living Limited | Construction | 2016 |
| Salkin Limited | Wholesale & retail | 2016 |
| Saltbox Business Park (Management) Limited | Real estate | 2019 |
| Saltcoats Nominees Limited | Professional & scientific | 2012 |
| Salters Wood Estates Limited | Other services | 2026 |
| Salthouse Rise Property Management Company Limited | Households | 2022 |
| Saltire Estates Ltd | Real estate | 2015 |
| Saltire Property Group Ltd | Construction | 2022 |
| Salvie Ltd | Professional & scientific | 2011 |
| SAM Highfield Film and Media Limited | Information & communication | 2014 |
| SAM Seccombe Films Ltd | Information & communication | 2024 |
| Samadrock Ltd | Mining & quarrying | 2024 |
| Samaki Holding Ltd | Real estate | 2022 |
| Samalex Limited | Real estate | 2000 |
| Samantha Harper Trading Ltd | Other services | 2025 |
| Samantha Knight Consultancy Ltd | Information & communication | 2018 |
| Samay Limited | Education | 2016 |
| Sambeth Estates Limited | Real estate | 2024 |
| Samc Two Limited | Real estate | 2011 |
| Samedica Limited | Health & social care | 2026 |
| Samgo Esates Ltd | Real estate | 2023 |
| Samiei Ltd | Wholesale & retail | 2025 |
| Samii Enterprise Ltd | Wholesale & retail | 2025 |
| Samjo Limited | Real estate | 2002 |
| Sammy's Pet Parlour Ltd | Other services | 2019 |
| Samob Ltd | Information & communication | 2020 |
| Samonanet Ltd | Construction | 2022 |
| Sample Beauty Ltd | Wholesale & retail | 2020 |
| Sample.Clo Limited | Wholesale & retail | 2025 |
| Samsol Limited | Real estate | 2016 |
| Samwa Ltd | Professional & scientific | 2025 |
| Sana Life Science Holdings Limited | Wholesale & retail | 2019 |
| Sana Life Science Ltd | Wholesale & retail | 2019 |
| Sana Lifestyle Ltd | Wholesale & retail | 2021 |
| Sandispeed Transport Services Ltd | Transport & logistics | 2018 |
| Sandon Road Fish Bar Limited | Hospitality | 2011 |
| Sandro Lopes - Architecture & Design Ltd | Construction | 2019 |
| Sandy Lane (London) Limited | Real estate | 2024 |
| Sandy Lane Coventry SPV Limited | Real estate | 2026 |
| Sandyx Customer Systems Limited | Information & communication | 2012 |
| Sandyx Systems Limited | Information & communication | 1995 |
| Sanghera Builders Ltd | Construction | 2023 |
| Sanity Homecare Ltd | Health & social care | 2023 |
| Santos Cheetham Hill Ltd | Hospitality | 2024 |
| Santos Kebab 1 Ltd | Hospitality | 2025 |
| Sanyu Investment (Holdings) Limited | Real estate | 2021 |
| Sanyu Property Investment and Management Limited | Real estate | 2019 |
| Sanz Estates Ltd | Real estate | 2016 |
| Saoud Lounge Ltd | Hospitality | 2026 |
| Sappers Enterprises Ltd | Wholesale & retail | 2025 |
| Sara Crown Holdings Ltd | Financial services | 2023 |
| Sara Jane Limited | Wholesale & retail | 2024 |
| Saramattypharma Ltd | Health & social care | 2024 |
| Saravoja Solutions (UK) Ltd | Professional & scientific | 2019 |
| Sargold Limited | Real estate | 2019 |
| Sashara Limited | Health & social care | 2014 |
| Sassov Ltd | Other services | 2025 |
| SAT Trans Logistic Ltd | Transport & logistics | 2025 |
| Satellite Estates Ltd | Extraterritorial | 2025 |
| Satin Services Ltd | Water & waste | 2025 |
| Satinstone Ltd | Real estate | 2017 |
| Satmar Kids Ltd | Health & social care | 2020 |
| Satmar Torah Group Ltd | Health & social care | 2025 |
| Satmar Torah Trust Ltd | Health & social care | 2013 |
| Satmer Mikvah Ltd | Other services | 2019 |
| Saturn Mart Ltd | Wholesale & retail | 2025 |
| Saul HAY Fine Art Limited | Wholesale & retail | 2015 |
| Savage Beautyluxe Limited | Other services | 2024 |
| Savage Law Limited | Professional & scientific | 2022 |
| Savage Real Estate Limited | Real estate | 2026 |
| Savemore Limited | Extraterritorial | 1996 |
| Saveu Ltd | Information & communication | 2017 |
| Savvu Ltd | Wholesale & retail | 2014 |
| Sawaya Comm Ltd | Wholesale & retail | 2013 |
| Sawcon Plant Limited | Construction | 2004 |
| Sayu Solutions Limited | Information & communication | 2024 |
| SB Appliances Outlet Limited | Wholesale & retail | 2026 |
| SB Estates MCR Ltd | Real estate | 2026 |
| SB Innovations Limited | Transport & logistics | 2023 |
| SB Printechx Limited | Manufacturing | 2024 |
| SB Pro Solutions Ltd | Construction | 2024 |