| RHG Payroll Services Ltd | Administrative & support | 2014 |
| Riboleau Community Studios and Garden CIC | Health & social care | 2024 |
| RKF Partnership Ltd | Wholesale & retail | 2025 |
| ROB Burton Maritime Training Limited | Education | 2020 |
| Rocket Ronnies (Ryde) Limited | Arts & recreation | 2020 |
| Rollesbrook Ltd | Real estate | 2024 |
| Rolling Start Films Limited | Information & communication | 2023 |
| Roman Vision Limited | Arts & recreation | 2003 |
| Rosseco Ltd | Other services | 2015 |
| Roubini Ltd | Hospitality | 2018 |
| Rowley Moor Properties Limited | Hospitality | 2014 |
| RP 157 Limited | Financial services | 1994 |
| RP 602 Limited | Real estate | 2010 |
| Rutina Services Limited | Other services | 2026 |
| RWS Developments (IOW) Ltd | Construction | 2021 |
| Ryde Arts C.I.C. | Arts & recreation | 2019 |
| Ryde Bookshop Limited | Wholesale & retail | 2002 |
| Ryde Esplanade Ltd | Other services | 2014 |
| Ryde Foxes Limited | Real estate | 2014 |
| Ryde Garage Limited | Wholesale & retail | 2018 |
| Ryde Harriers Limited | Arts & recreation | 2018 |
| Ryde Hive CIC | Education | 2025 |
| Ryde Holdings Ltd | Real estate | 2018 |
| Ryde House Care Group Ltd | Financial services | 2014 |
| Ryde House Homes Ltd | Health & social care | 2004 |
| Ryde House Outreach Services Ltd | Extraterritorial | 2014 |
| Ryde Launderette Ltd | Other services | 2013 |
| Ryde Management Company Limited | Real estate | 1989 |
| Ryde Marina Bowls Club Limited | Arts & recreation | 2003 |
| Ryde Motors (Isle of Wight) Limited | Wholesale & retail | 1990 |
| Ryde Nails and Spa Limited | Other services | 2024 |
| Ryde Revival CIC | Construction | 2024 |
| Ryde Saints Football Club Community Interest Company | Arts & recreation | 2013 |
| Ryde School Construction Limited | Construction | 2016 |
| Ryde Self Storage Ltd | Transport & logistics | 2020 |
| Ryde Social Support and Community Arts Ltd | Real estate | 2022 |
| Ryde Steak House Limited | Hospitality | 2026 |
| Ryde Tandoori Restaurant Ltd | Hospitality | 2004 |
| Ryde Taxis IOW Limited | Transport & logistics | 2015 |
| Rydeontyme Ltd | Wholesale & retail | 2025 |
| Rydeport (2000) Limited | Transport & logistics | 2021 |
| Rydepunk Ltd | Wholesale & retail | 2018 |
| Ryecon Limited | Construction | 2018 |
| S Binder Ltd | Health & social care | 2012 |
| S Mcarthur and Sons Ltd | Hospitality | 2023 |
| S&S Accounting Services Ltd | Professional & scientific | 2019 |
| S. Whittington Ltd. | Construction | 2011 |
| Safesite (Isle of Wight) Ltd | Administrative & support | 2013 |
| Saint Valentines Catering Group Ltd. | Hospitality | 2018 |
| Sally Water Taxis Limited | Transport & logistics | 2003 |
| Samantha Vine Accountancy Services Ltd | Professional & scientific | 2025 |
| Samspeopleprints Limited | Professional & scientific | 2025 |
| Sandbank Studios Limited | Information & communication | 2018 |
| Sanyals Ltd | Health & social care | 2020 |
| Sapper Surveys Limited | Professional & scientific | 2011 |
| Sarah Murgatroyd CBT Ltd | Health & social care | 2026 |
| Saxonbury House Management Company Limited | Financial services | 1995 |
| SC Kebab House Ltd | Hospitality | 2024 |
| Scaffolding Services IW Ltd | Construction | 2025 |
| SCL Fire Protection Ltd | Construction | 2021 |
| Scudder Properties Limited | Real estate | 2023 |
| SDS Scaffolding (I.W.) Limited | Construction | 2014 |
| Seabreeze Maintenance Company Limited | Real estate | 2002 |
| Seahorse Distillery Ltd | Wholesale & retail | 2025 |
| Seascape Management Company (IW) Limited | Households | 2019 |
| Seasure Shipbroking Ltd | Professional & scientific | 2005 |
| Seaview Financial Services Limited | Financial services | 2013 |
| Seaview Scaffold Ltd | Construction | 2026 |
| Seaward Brokerage Limited | Wholesale & retail | 2025 |
| Seldom Rest Limited | Professional & scientific | 2021 |
| Selene Signs Limited | Manufacturing | 2014 |
| Sense Inclusion C.I.C. | Health & social care | 2020 |
| Sensory Space CIC | Health & social care | 2019 |
| Sentis Technology Limited | Administrative & support | 2020 |
| Sentplaza Limited | Real estate | 2008 |
| Serendipity Diamonds Limited | Manufacturing | 2006 |
| Shademakers Trading Company Ltd | Arts & recreation | 2026 |
| Shademakers UK Arts (Trading AS Shademakers UK) CIC | Arts & recreation | 2015 |
| Shades of Wight Limited | Extraterritorial | 2016 |
| Shanklin (High Street) Management Company Limited | Real estate | 2005 |
| Sheer Pink Ltd | Professional & scientific | 2021 |
| Siela Ltd | Construction | 2020 |
| Siffco Limited | Transport & logistics | 2007 |
| Silver Arch Holiday LET Solutions Limited | Administrative & support | 2024 |
| Silver Arch Property Solutions Limited | Financial services | 2023 |
| Silver Seas Property Ltd | Real estate | 2025 |
| SM IOW Ltd | Hospitality | 2023 |
| Smartek Systems Ltd | Construction | 2018 |
| Smiles of Wight Ltd | Health & social care | 2018 |
| Smith and Woodfield Ltd | Wholesale & retail | 2022 |
| SO Yummy IOW Ltd | Hospitality | 2019 |
| Solcom Limited | Information & communication | 1998 |
| Solent Court Management Company (I W) Limited | Real estate | 1997 |
| Solent Inn Ryde Ltd | Hospitality | 2018 |
| Solent Lettings IOW Ltd | Other services | 2024 |
| Southern Integrated Solutions Ltd | Professional & scientific | 2015 |
| SRA Coaching Ltd | Administrative & support | 2024 |
| SRB Foods Ltd | Hospitality | 2025 |
| ST Catherines Property Management Ltd | Construction | 2022 |
| ST Mary's Abbey, Quarr | Other services | 2015 |