| Samuel Banner & Co. Limited | Manufacturing | 1991 |
| Samuel Banner Pension Fund Limited | Professional & scientific | 1982 |
| Samuel Banner Property Co Limited | Administrative & support | 2014 |
| Samuel James Catering Ltd | Hospitality | 2019 |
| Samuel James Events Ltd | Hospitality | 2013 |
| Sanchaz Limited | Manufacturing | 2025 |
| Sandon Global Engineering Ltd | Manufacturing | 1997 |
| Sandon Global Engraving Technology Limited | Manufacturing | 2004 |
| Sapropel Organics Ltd | Wholesale & retail | 2023 |
| Sapwise Limited | Administrative & support | 2020 |
| Sare Services Limited | Construction | 2025 |
| Satmar Installations Ltd | Manufacturing | 2020 |
| Saughall Arms (Gastro) Limited | Hospitality | 2024 |
| Savepound Ltd | Wholesale & retail | 2020 |
| SB Accountancy (NW) Ltd | Professional & scientific | 2018 |
| Sbkitchens Ltd | Construction | 2025 |
| Scaffold Jobs Limited | Construction | 2019 |
| Scentwaves Ltd | Wholesale & retail | 2025 |
| Screentextiles Limited | Wholesale & retail | 2016 |
| SDA Joinery & Kitchens Ltd | Construction | 2021 |
| Seal Consulting North West Ltd | Professional & scientific | 2024 |
| Sean Bailey Wellness CIC | Education | 2020 |
| Sean Kennedy Haulage Limited | Transport & logistics | 2018 |
| Search Creative Ltd | Information & communication | 2011 |
| SEB Electrical & Building Ltd | Construction | 2018 |
| SEB Picture Vehicles Limited | Information & communication | 2025 |
| Secta Integrated Solutions Ltd | Construction | 2019 |
| Securitech Services Limited | Professional & scientific | 2016 |
| Seemoor Limited | Administrative & support | 2014 |
| Selwyns Travel Limited | Transport & logistics | 1978 |
| Semara Contract Services Limited | Professional & scientific | 1964 |
| Semara Estates Limited | Professional & scientific | 1947 |
| Semara Group Limited | Professional & scientific | 1984 |
| Semara Investments Limited | Professional & scientific | 1965 |
| Semara Nominees Limited | Professional & scientific | 1939 |
| Semara Trustees Limited | Professional & scientific | 1968 |
| Sensible Choice Limited | Administrative & support | 2010 |
| Serenity Seekers CIC | Education | 2024 |
| Service Developments Ltd | Other services | 2023 |
| Servicepoint Solutions Ltd | Information & communication | 2019 |
| Sevenoaks Enterprises Limited | Transport & logistics | 2002 |
| SG Recycling Ltd | Administrative & support | 2016 |
| Shachihata (Europe) Ltd. | Wholesale & retail | 1998 |
| Shakil Chaudary Ltd | Professional & scientific | 2026 |
| Shamrock Logistics Limited | Transport & logistics | 1998 |
| Shandon Diagnostics Limited | Manufacturing | 1937 |
| Shanko's Skate School C.I.C. | Education | 2023 |
| Shapers Hair Limited | Other services | 2021 |
| Shaw’S Engineering Limited | Construction | 2018 |
| Shepherd Construction Services Ltd | Construction | 2024 |
| Sherlocks Pet & Co Ltd | Wholesale & retail | 2022 |
| Shiny Spaces Ltd | Administrative & support | 2025 |
| SHK Properties Ltd | Real estate | 2014 |
| Shockin UK Ltd | Wholesale & retail | 2024 |
| Shun Shun LI LI Limited | Hospitality | 2019 |
| Sigmatex (UK) Limited | Manufacturing | 1986 |
| Signature CVS Limited | Administrative & support | 2011 |
| Signature Elite Coaching Academy Ltd | Arts & recreation | 2024 |
| Sila Contracts Limited | Construction | 1999 |
| Silkstone RCS Ltd | Construction | 2019 |
| Silver Crown Pizza (Runcorn) Limited | Hospitality | 2018 |
| Silveredge Property Group Ltd | Real estate | 2025 |
| Simon Corrugating Machinery Limited | Manufacturing | 2003 |
| Simon Europe Limited | Professional & scientific | 2003 |
| Simple Driving Ltd | Transport & logistics | 2017 |
| Simplelight Limited | Energy | 2015 |
| Simply Analysis Limited | Real estate | 2000 |
| Simply Car Group Limited | Professional & scientific | 2026 |
| Simply Secured Solutions Ltd | Administrative & support | 2025 |
| Siric Limited | Information & communication | 2015 |
| Sister ACT Cleaning Ltd | Administrative & support | 2020 |
| SJ Developments (UK) Ltd | Real estate | 2005 |
| SJC Driving Services Limited | Transport & logistics | 2014 |
| SK and M Ltd | Wholesale & retail | 2023 |
| Skill Zone Limited | Information & communication | 1998 |
| Skillgap Ltd | Education | 2019 |
| Skills UP CIC | Education | 2019 |
| Skills UP NW Ltd | Public administration | 2024 |
| Skip IT Quick Limited | Manufacturing | 2016 |
| Skmk Property Services Ltd | Households | 2018 |
| Skyline Property Ventures Ltd | Real estate | 2026 |
| SL Accounts Ltd | Professional & scientific | 2025 |
| Slice of Chicago Pizza Ltd | Hospitality | 2023 |
| SLN Group Limited | Hospitality | 2019 |
| Slumberjack Entertainment Ltd | Information & communication | 2016 |
| SM Electrical Services (NW) Ltd | Construction | 2020 |
| Small Batch Brewing Co Ltd | Manufacturing | 2020 |
| Smart Property Living Ltd | Real estate | 2025 |
| Smart Vape Away Ltd | Wholesale & retail | 2025 |
| Smartgreenchargers Ltd | Construction | 2022 |
| Smartserve Solutions Ltd | Hospitality | 2022 |
| SMB83 Consulting Ltd | Administrative & support | 2025 |
| Smiths Waste Removals & Skip Hire Ltd | Water & waste | 2024 |
| Smithwork Holdings Ltd | Real estate | 2025 |
| SMR Timber Frame Specialists Ltd | Manufacturing | 2020 |
| SMW Elec Limited | Mining & quarrying | 2014 |
| SNK Haulage Services Limited | Transport & logistics | 2023 |
| Soccer Culture Limited | Wholesale & retail | 1997 |
| Social Media Marvel Ltd | Professional & scientific | 2023 |
| Socialcru Ltd | Construction | 2016 |