| Socialcru Services Limited | Administrative & support | 2019 |
| SOG Resources Limited | Administrative & support | 2010 |
| Solar Superior Ltd | Administrative & support | 2022 |
| Soph True Fitness Ltd | Other services | 2023 |
| Sophia Cheung Foods Ltd | Hospitality | 2024 |
| Sophisticated Clothing Ltd | Wholesale & retail | 2025 |
| Sophisticated Cosmetics Ltd | Wholesale & retail | 2021 |
| Soul Tonic Counselling Ltd | Health & social care | 2024 |
| Soulfood Junction Ltd | Hospitality | 2025 |
| Soulful Healing Ltd | Education | 2025 |
| Sovereign Couture Ltd | Wholesale & retail | 2023 |
| Sowler International Consultancy Ltd | Professional & scientific | 2022 |
| Spa Luxe Group Ltd | Transport & logistics | 2026 |
| Space Runcorn CIC | Health & social care | 2023 |
| Spaceforme Holdings Limited | Manufacturing | 2017 |
| Spaceforme Limited | Professional & scientific | 2011 |
| Sparkling Superior Ltd | Administrative & support | 2025 |
| Spdie Limited | Administrative & support | 2017 |
| Specialistae Consultants Ltd | Professional & scientific | 2025 |
| Speciality Food Ingredients Limited | Professional & scientific | 1982 |
| Spectralworks Ltd | Information & communication | 2004 |
| Spectrum Array Ltd | Manufacturing | 2022 |
| Spgn Ltd | Hospitality | 2025 |
| SPH Resourcing Limited | Information & communication | 2018 |
| Spheritech Limited | Professional & scientific | 2009 |
| SPJ Mechanical Services Limited | Manufacturing | 2019 |
| Sports Store Direct Limited | Wholesale & retail | 2021 |
| Spruce Hire Limited | Transport & logistics | 2014 |
| SPX Direct Limited | Transport & logistics | 2025 |
| Square CUT Carpentry & Joinery Ltd | Manufacturing | 2022 |
| Squared Joinery Ltd | Construction | 2025 |
| SS & R Property Ltd | Real estate | 2025 |
| ST Domingo Football Club Ltd | Arts & recreation | 2020 |
| Stage Two (UK) Ltd. | Information & communication | 2012 |
| Stalbridge Linen Services Limited | Professional & scientific | 1995 |
| Star Storycrafters Limited | Professional & scientific | 2023 |
| Stardust Apparel Limited | Wholesale & retail | 2024 |
| Startool Ltd | Wholesale & retail | 2022 |
| Statham Holdings Limited | Financial services | 2015 |
| Statham Tyres & Co (UK) Limited | Manufacturing | 2006 |
| Stealth Developments Manchester Limited | Arts & recreation | 2010 |
| Steele Distribution Ltd | Wholesale & retail | 2023 |
| Steele Holdings Limited | Real estate | 2019 |
| Steo Trans Ltd | Transport & logistics | 2018 |
| Sterling Inks UK Ltd | Manufacturing | 2011 |
| Sterlins Digital Ltd | Information & communication | 2021 |
| Stewart Brothers Property Group Limited | Extraterritorial | 2022 |
| Still Available Ltd | Wholesale & retail | 2022 |
| Stonecrop Web Consulting Ltd | Information & communication | 2025 |
| Stop and Store (Hampshire) Ltd | Real estate | 2019 |
| Stop and Store (LS 2020) Ltd | Real estate | 2020 |
| Stop and Store Ltd | Real estate | 2011 |
| Stop OFF Homesteads Ltd | Real estate | 2022 |
| Stowlin Croftshaw Limited | Extraterritorial | 2009 |
| Stowlin Limited | Manufacturing | 1972 |
| Stowlin Specialised Chemicals Limited | Professional & scientific | 1981 |
| Straight Eight Special Vehicles Limited | Transport & logistics | 2021 |
| Stratus Automation Ltd | Information & communication | 2025 |
| Stroke of Midnight Ltd | Arts & recreation | 2026 |
| STT Holdings Ltd | Construction | 2021 |
| Stubbox Ltd | Administrative & support | 2026 |
| Styledas Limited | Professional & scientific | 2025 |
| Subbly Market Ltd | Information & communication | 2026 |
| Summit Constructions Limited | Construction | 2013 |
| Sun Spa Runcorn Limited | Other services | 2018 |
| Sunleaf Energy Ltd | Construction | 2025 |
| Sunny Runny Productions Ltd | Information & communication | 2025 |
| Super Shine Car Wash Runcorn Ltd | Other services | 2025 |
| Superior Spray Solutions Ltd | Construction | 2020 |
| Sureserve Fulfilment Ltd | Transport & logistics | 2026 |
| Surfachem International Limited | Professional & scientific | 1992 |
| Sweet Like Choccy Limited | Wholesale & retail | 2025 |
| Swiftscale Supply Ltd | Wholesale & retail | 2025 |
| Swissport Cargo Services UK Ltd | Transport & logistics | 1992 |
| Swissport Fuelling Ltd | Transport & logistics | 2004 |
| Swissport Fuelling Services UK Limited | Transport & logistics | 2011 |
| Swissport GB Limited | Transport & logistics | 1952 |
| Swissport Group UK Limited | Professional & scientific | 1967 |
| Swissport Holdings Limited | Professional & scientific | 1995 |
| Swissport Ltd | Transport & logistics | 1999 |
| Swissport Stansted Ltd | Transport & logistics | 2001 |
| Swissport UK Holding Limited | Transport & logistics | 2010 |
| Switch Cars 24/7 Ltd | Wholesale & retail | 2019 |
| Synchro Project Management Ltd | Professional & scientific | 2012 |
| Synotech Ltd | Wholesale & retail | 2025 |
| Syntor Specialties | | 2005 |
| Systeem Group Ltd | Information & communication | 2020 |
| Systeem Limited | Information & communication | 2014 |
| System Devices UK Limited | Professional & scientific | 2005 |
| Szczepaniak Transport Ltd | Transport & logistics | 2017 |
| T and S Falcons. Limited | Agriculture & fishing | 2015 |
| T M Plastics Limited | Manufacturing | 2004 |
| T&S Driver Hire Limited | Transport & logistics | 2019 |
| T.O Transport and Recovery Ltd | Transport & logistics | 2025 |
| Taamiha Limited | Transport & logistics | 2014 |
| Take a Laptop Home Ltd | Wholesale & retail | 2020 |
| Talk Heating and Plumbing Services Limited | Construction | 2016 |
| TAN Enterprise Ltd | Wholesale & retail | 2021 |
| Tandoori Night (NW) Ltd | Hospitality | 2017 |
| Target Mind Limited | Professional & scientific | 2010 |