| Ravian Retail Ltd | Wholesale & retail | 2022 |
| RAW! Catering Ltd | Hospitality | 2019 |
| Razor Hair CUT Ltd | Other services | 2025 |
| RB Site Services Ltd | Construction | 2026 |
| Rbttr Limited | Transport & logistics | 2025 |
| RCE Civil Engineers Ltd | Administrative & support | 2012 |
| RCE Group Limited | Financial services | 2017 |
| Rcvc Topco Limited | Professional & scientific | 2023 |
| Reach Access Limited | Professional & scientific | 2018 |
| React Sportswear Ltd | Wholesale & retail | 2020 |
| Reagent Chemical Services Limited | Manufacturing | 1977 |
| Reagent Investments Limited | Real estate | 2003 |
| Rebecca Alice Ltd | Other services | 2025 |
| Recharge and Restore CIC | Health & social care | 2017 |
| Record, the Biodiversity Information System for Cheshire, Halton, Warrington and Wirral | Information & communication | 2000 |
| Red FOX Business Services Limited | Administrative & support | 2025 |
| Red Lion (Penyffordd) Ltd | Hospitality | 2020 |
| Redit Tech Solutions Ltd | Information & communication | 2024 |
| Refrig Services Ltd | Professional & scientific | 2026 |
| Regent Barbers Ltd | Other services | 2022 |
| Reload Campers Ltd | Wholesale & retail | 2020 |
| Reload Custom Ltd | Manufacturing | 2025 |
| Remedi Healthcare Limited | Wholesale & retail | 2024 |
| Rendells Hair Studio Limited | Other services | 2000 |
| Rennicks (U.K.) Limited | Manufacturing | 2017 |
| Renovations of Cheshire NW Ltd | Construction | 2024 |
| Revive Build Maintenance Ltd | Construction | 2023 |
| Reynolds Dairyman Limited | Wholesale & retail | 2012 |
| RG Takeaway Runcorn Ltd | Hospitality | 2025 |
| Rgfc Ltd | Hospitality | 2019 |
| Rhco Properties Ltd | Real estate | 2025 |
| Rhinestone Investments Limited | Real estate | 2026 |
| Rhino Machinery UK Ltd | Wholesale & retail | 2025 |
| RHK Consultancy Solutions Ltd | Professional & scientific | 2026 |
| Rickitt & Co Limited | Financial services | 2019 |
| Rickitt Partners Limited | Real estate | 2020 |
| Rico HR Consultancy Ltd | Administrative & support | 2018 |
| Ridgeline Property Group Ltd | Real estate | 2026 |
| Right Choice Building Services Limited | Construction | 2009 |
| Ringway Plumbing Supplies Limited | Wholesale & retail | 2002 |
| Rinnai UK Limited | Wholesale & retail | 1976 |
| Rise Architectural Systems Ltd | Manufacturing | 2023 |
| Riva-Ron Ltd | Transport & logistics | 2026 |
| Riverside Spirits Ltd | Manufacturing | 2011 |
| RMC UK Properties Ltd | Construction | 2023 |
| RN Ducting Services Ltd | Energy | 2019 |
| RNA Materials Consultants Ltd. | Construction | 2015 |
| RNC Training Services Ltd | Administrative & support | 2006 |
| Roadhome Campers Ltd | Wholesale & retail | 2019 |
| Robert Greig Limited | Real estate | 2012 |
| Robinson Nicholls Ltd | Manufacturing | 2026 |
| Robinson's Steel Erectors Ltd | Construction | 2020 |
| Roboserve Limited | Professional & scientific | 1967 |
| Rock Farm Meats Ltd | Wholesale & retail | 2025 |
| Rockwood Living Ltd | Real estate | 2025 |
| Romer Labs UK Limited | Professional & scientific | 2009 |
| RON RAY Properties Ltd | Real estate | 2025 |
| Rondec's Ltd | Transport & logistics | 2016 |
| Rose Cottage Veterinary Centre Limited | Professional & scientific | 2010 |
| Rotating Equipment Engineering Services Limited | Professional & scientific | 2024 |
| Roten Seal Supplies Limited | Manufacturing | 1995 |
| Roundhouse PUB Limited | Hospitality | 2015 |
| Rowing Design Ltd | Manufacturing | 2016 |
| RS Lashes Ltd | Other services | 2022 |
| RUM & Raspberry Ltd | Arts & recreation | 2026 |
| Runcorn 1964 Limited | Extraterritorial | 2014 |
| Runcorn Boating Services Limited | Transport & logistics | 2013 |
| Runcorn Electrical Limited | Construction | 2002 |
| Runcorn Fresh Bites Ltd | Hospitality | 2025 |
| Runcorn Golf Club Limited | Arts & recreation | 1999 |
| Runcorn Hand Car Wash Limited | Administrative & support | 2021 |
| Runcorn Haulage Limited | Transport & logistics | 2024 |
| Runcorn MCP Limited | Manufacturing | 2014 |
| Runcorn Model Association Limited | Arts & recreation | 1995 |
| Runcorn Pizzaria Ltd | Hospitality | 2025 |
| Runcorn Powder Coatings Limited | Manufacturing | 2022 |
| Runcorn Recovery & Car Transportation Ltd | Wholesale & retail | 2023 |
| Runcorn Skyline Ltd | Construction | 2021 |
| Runcorn Specsavers Limited | Wholesale & retail | 1992 |
| Runcorn Tyre and Service Centre Limited | Manufacturing | 2017 |
| Runcorn Visionplus Limited | Wholesale & retail | 1992 |
| Rustic Hanger and Soles Ltd | Wholesale & retail | 2026 |
| RW Painting & Decorating Limited | Construction | 2012 |
| RWS Transport Ltd | Transport & logistics | 2018 |
| S & M Select Limited | Wholesale & retail | 2012 |
| S Brierley Property Ltd | Real estate | 2024 |
| S Crowley Groundworks Ltd | Construction | 2018 |
| S-Lewtions Ltd | Professional & scientific | 2025 |
| S.Long & Sons Logistics Limited | Transport & logistics | 2014 |
| Safeway GAS Services Ltd | Construction | 2020 |
| Saga Projects Limited | Construction | 2016 |
| Saga Supplies Ltd | Wholesale & retail | 2022 |
| Saharan Venture Ltd | Extraterritorial | 2016 |
| Sales Excellence Ltd | Education | 2025 |
| Salter & Co Holdings Limited | Real estate | 2026 |
| Salute North West Ltd | Construction | 2023 |
| SAM Jones Joinery NW Ltd | Construction | 2019 |
| Sam's Erturk Ltd | Other services | 2021 |
| Samantha Dando - Luxury Travel Limited | Administrative & support | 2021 |
| Samba Runcorn Ltd | Arts & recreation | 2025 |