| S M E Enterprise Limited | Hospitality | 1985 |
| S P Infra Limited | Construction | 2024 |
| S S Associates Ltd | Real estate | 1999 |
| S W Roofers and Decorators Limited | Construction | 2023 |
| S&M (Stonebridge Park) Limited | Hospitality | 2002 |
| S&P Consultancy Ltd | Construction | 2014 |
| S&S Property Trading Ltd | Real estate | 2024 |
| S.O.U.L Film Festival Ltd | Arts & recreation | 2019 |
| S.T.C.Plumbing & Heating Merchants Limited | Wholesale & retail | 1972 |
| S4 HEL Beauty Serums Ltd | Wholesale & retail | 2026 |
| S9DESIGNS Consultants Limited | Professional & scientific | 2023 |
| SA Developments (Midlands) Limited | Construction | 2023 |
| SA Pathfinders Limited | Professional & scientific | 2026 |
| SA Scaffolding Ltd | Construction | 2007 |
| SA Sparks Ltd | Construction | 2021 |
| Saaj Investments Limited | Real estate | 2009 |
| Saanvi Savi Limited | Real estate | 2021 |
| Saathi Group Limited | Information & communication | 2021 |
| SAB Business Consulting Limited | Information & communication | 2013 |
| Sabiha Habib T/A Vision Plus Opticians Ltd | Wholesale & retail | 2023 |
| Sabinus Building Services Ltd | Construction | 2016 |
| Sabish Limited | Wholesale & retail | 2019 |
| Sablon Audio Limited | Manufacturing | 2020 |
| Sabode Limited | Real estate | 2018 |
| Sacre Bleu Ltd | Manufacturing | 2019 |
| Sadaf Sultani Companies Limited | Wholesale & retail | 2025 |
| Safaridor Ltd | Transport & logistics | 2016 |
| Safe and Sound Installations Ltd | Other services | 2020 |
| Safemark Supplies Ltd | Wholesale & retail | 2023 |
| Safety North East Ltd | Professional & scientific | 2018 |
| Sagebooks Ltd | Professional & scientific | 2019 |
| Sagesse Moisson Limited | Information & communication | 2004 |
| Sagoo Group Limited | Health & social care | 2015 |
| Sagoo Limited | Health & social care | 2013 |
| Sagoore Ltd | Construction | 2026 |
| Sahar Properties Limited | Real estate | 2022 |
| Sahota Property Management Limited | Construction | 2018 |
| Saif FM Ltd | Administrative & support | 2022 |
| Saifee Properties Limited | Real estate | 2017 |
| Sajams Ltd | Wholesale & retail | 2024 |
| Saker Developments Ltd | Real estate | 2020 |
| Salaghan Properties Ltd | Real estate | 2020 |
| Salaria Auto PVT Ltd | Wholesale & retail | 2009 |
| Salem PM Services Ltd | Professional & scientific | 2024 |
| Salford College of Science and Arts Ltd | Education | 2024 |
| Salux Consulting Limited | Information & communication | 2014 |
| SAM Robbins Estate Agents Ltd | Real estate | 2026 |
| Samantha Carbon Therapy Ltd | Health & social care | 2017 |
| Samoliss Ltd | Construction | 2025 |
| Samson and Lola Limited | Households | 2016 |
| Samsunlu 55 Ltd | Hospitality | 2016 |
| Samz Plumbing Limited | Other services | 2013 |
| Sana Investments Limited | Wholesale & retail | 1994 |
| Sanaa Harroussi Ltd | Health & social care | 2012 |
| Sandmoor House Management Limited | Households | 2007 |
| Sangad Group Ltd | Transport & logistics | 2021 |
| Sanhe Xingshuo Fiberglass Products Co., Ltd | Administrative & support | 2020 |
| Sanmai Technologies and Marketing Limited | Information & communication | 2018 |
| Sansara Massage Ltd | Other services | 2013 |
| Santhosh Engineering Limited | Professional & scientific | 2021 |
| Sanville Holdings Limited | Financial services | 2023 |
| Sanville Properties Ltd | Real estate | 2023 |
| Sapphire Autos Ltd | Wholesale & retail | 2009 |
| Sapphire Cart Ltd | Wholesale & retail | 2025 |
| Sapphire Interiors Limited | Wholesale & retail | 2020 |
| Sapthika Limited | Wholesale & retail | 2013 |
| Sarah & Sayf Estate Ltd | Real estate | 2022 |
| Sarbha Technology Limited | Information & communication | 2013 |
| Sarogirg Limited | Construction | 2023 |
| Sarton Carpentry Ltd | Manufacturing | 2025 |
| Sarvi Food Ltd | Hospitality | 2025 |
| SAS Actuarial Services Limited | Professional & scientific | 2019 |
| SAS Ventures Limited | Professional & scientific | 2020 |
| Satarno Limited | Wholesale & retail | 2025 |
| Sauber Pictures Ltd | Information & communication | 2023 |
| Saucy WOW Ltd | Manufacturing | 2026 |
| Sause Ltd | Wholesale & retail | 2024 |
| Savoys Capital LLP | | 2018 |
| Savoys Development Ltd | Construction | 2017 |
| Savoys Education Ltd | Education | 2023 |
| Savoys Group LLP | | 2021 |
| Savoys Lending Ltd | Financial services | 2019 |
| Savoys North Ltd | Real estate | 2024 |
| Savoys Properties Ltd | Real estate | 2013 |
| Savoys Real Estate Ltd | Real estate | 2024 |
| Sawfa Technologies Ltd | Information & communication | 2023 |
| Saxons Direct Ltd | Wholesale & retail | 2025 |
| Saxton Enterprises Ltd | Information & communication | 2020 |
| Saya Associates Limited | Professional & scientific | 2013 |
| Sayona Exports Limited | Wholesale & retail | 2000 |
| SBC Shutters Blinds Curtains Ltd | Wholesale & retail | 2019 |
| SBS Motors Ltd | Administrative & support | 2010 |
| SC Home Improvements Limited | Construction | 2019 |
| Scag Foods Limited | Hospitality | 2019 |
| Scalpmicrouk Limited | Health & social care | 2016 |
| Scalptist Ltd. | Real estate | 2015 |
| Scalptist Training Limited | Other services | 2023 |
| Scandinavian Capital Partners Ltd | Financial services | 2020 |
| Scarlettsun Limited | Wholesale & retail | 2015 |
| Scbase Limited | Information & communication | 2011 |