| Scene That? Ltd | Information & communication | 2024 |
| Scholars Walk (Bishops Stortford) Management Company Limited | Households | 2026 |
| Scmc Limited | Professional & scientific | 2016 |
| Scol Care Ltd | Financial services | 2026 |
| Scorp Group Ltd | Information & communication | 2021 |
| Scotmark Organization LLP | | 2008 |
| Scott Commercial Services Ltd | Construction | 2021 |
| Scott Heating and Electrical Limited | | 1964 |
| Scrap the Car Today Ltd | Wholesale & retail | 2022 |
| Screebits Ltd | Information & communication | 2019 |
| Screen 3 Productions Ltd | Information & communication | 2017 |
| Scuff Surgeon Limited | Administrative & support | 2024 |
| SD Advisory & Capital Ltd | Financial services | 2018 |
| SD Roofing & Guttering Services Limited | Construction | 2025 |
| Seacoast Logistics Ltd | Wholesale & retail | 2024 |
| Seafield Court Management Limited | Administrative & support | 2004 |
| Seawind Ocean Technology Ltd | Manufacturing | 2019 |
| Secondb Holdings Ltd | Professional & scientific | 2020 |
| Secondb Solutions Ltd | Administrative & support | 2014 |
| Secret Circus CIC | Education | 2026 |
| Secret Codex Ltd | Information & communication | 2014 |
| Secure Centric Limited | Information & communication | 2017 |
| Securiter Limited | Extraterritorial | 2020 |
| Sedgwick Ltd | Real estate | 2021 |
| SEE3D Ltd | Professional & scientific | 2025 |
| Sejal Shah Ltd | Real estate | 2024 |
| Selca Investments Ltd | Construction | 2024 |
| Selebrem Trading Limited | Wholesale & retail | 2000 |
| Select Invest Limited | Real estate | 1998 |
| Select London Properties Ltd | Real estate | 2024 |
| Select ME Ltd | Administrative & support | 2024 |
| Selva Property Investments Ltd | Real estate | 2016 |
| Selwyn Miles Limited | Professional & scientific | 2002 |
| Senaomi Healthcare Ltd | Health & social care | 2021 |
| Sensatec Ltd | Administrative & support | 2002 |
| Sentient Education Ltd | Professional & scientific | 2018 |
| Seos HUT Ltd | Information & communication | 2024 |
| Serbu Trans Ltd | Wholesale & retail | 2023 |
| Serena Euro Ltd | Wholesale & retail | 2020 |
| Serenity 360 Clinic Ltd | Wholesale & retail | 2025 |
| Serenity Care Estate Limited | Construction | 2026 |
| Seriatim Limited | Construction | 1999 |
| Serva Consulting Ltd | Professional & scientific | 2026 |
| Service Limited | Health & social care | 1986 |
| SET in Bricks Ltd | Real estate | 2023 |
| Seujet Automation Ltd | Information & communication | 2022 |
| Seven Oceans Motors Ltd | Wholesale & retail | 2022 |
| Seven Oceans Ventures Ltd | Real estate | 2022 |
| Seventy Four Construction Ltd | Construction | 2020 |
| Sewob Limited | Real estate | 2016 |
| Sezak Ltd | Hospitality | 2026 |
| Sfbp Ltd. | Construction | 2022 |
| SGB Capital Limited | Professional & scientific | 2010 |
| SGB Ventures Limited | Information & communication | 2018 |
| SGK Capital LLP | | 2019 |
| SH Football Acadamy Limited | Arts & recreation | 2020 |
| Shadow Holding Europe Ltd | Financial services | 2025 |
| Shai Habibi Limited | Wholesale & retail | 2025 |
| Shakespeare Coaches Ltd | Transport & logistics | 2023 |
| Shakti Foods Private Ltd | Hospitality | 2025 |
| Shali Enterprise Ltd | Real estate | 2020 |
| Shallome of Zion Ltd | Real estate | 2020 |
| Shami Bakery Ltd | Manufacturing | 2026 |
| Shampson Consultancy Limited | Professional & scientific | 2024 |
| Shandong Laituo Machinery Co., Ltd | Wholesale & retail | 2024 |
| Shane Steyn Stunts Limited | Other services | 2016 |
| Shanghai Chunshui Shipping Store Co., Ltd | Administrative & support | 2023 |
| Shanghai Enzhan Marine Equipment Co., Ltd | Wholesale & retail | 2024 |
| Shanghai Juxu Trading Co., Ltd | Extraterritorial | 2018 |
| Shaoxing Shangyu Lonfei Mould Co., Ltd. | Wholesale & retail | 2019 |
| Shaurya Limited | Transport & logistics | 2021 |
| Shbb Properties Limited | Real estate | 2024 |
| Sheargold Limited | Wholesale & retail | 1991 |
| Shekhinah Capital Limited | Professional & scientific | 2011 |
| Shelf IQ Limited | Information & communication | 2026 |
| Shellen Construction Limited | Construction | 1996 |
| Shellen Holdings Limited | Construction | 2014 |
| Shellen Homes Limited | Real estate | 2009 |
| Shellen Security Limited | Construction | 2013 |
| Shenai Weddings London Ltd | Hospitality | 2022 |
| Shenyang Baoerfu Technology Co., Ltd | Extraterritorial | 2019 |
| Shenzhen Amnice Technology Development Co., Ltd | Wholesale & retail | 2023 |
| Shepherd & Brown Consulting Limited | Professional & scientific | 2023 |
| Sheppard Construction Limited | Real estate | 2013 |
| Shepri Limited | Real estate | 2024 |
| Sherrygold (Restaurants) Limited | Hospitality | 1995 |
| Sherrygold NO.1 Limited | Real estate | 2002 |
| Sherrygold NO.3 Limited | Financial services | 2002 |
| Shibida Global Logistics Co., Ltd. | Administrative & support | 2021 |
| Shield Fire Protection Services Limited | Construction | 2025 |
| Shift Holdings Ltd | Information & communication | 2020 |
| Shikam Limited | Real estate | 2025 |
| Shiloh Estates Limited | Real estate | 2025 |
| Shine Beauty Ltd | Other services | 2024 |
| Shine Business Ltd | Real estate | 2020 |
| Shineark Limited | Information & communication | 2011 |
| Shineworks Ltd | Construction | 2026 |
| Shirak & Daughters Investment Ltd | Real estate | 2023 |
| Shiv Logistic PVT Ltd | Wholesale & retail | 2023 |
| Shiv Saaj Investments Limited | Real estate | 2009 |