| Specialist Career Services Limited | Education | 2010 |
| Specialist Physiocare Clinics Limited | Health & social care | 2020 |
| Specialist Recruitment Services UK Ltd | Administrative & support | 2008 |
| Specialized Engineering Limited | Professional & scientific | 2025 |
| Speedex Motor Oils Ltd | Wholesale & retail | 2023 |
| Speedv Ltd | Transport & logistics | 2026 |
| Speedway Futures Ltd | Arts & recreation | 2024 |
| Spice House Rugby Ltd | Hospitality | 2025 |
| Spice Venue Ltd | Real estate | 2025 |
| Spicy Joes Ltd | Hospitality | 2021 |
| Spinta Limited | Transport & logistics | 2021 |
| Spiratech Ltd | Professional & scientific | 2021 |
| Spires GAS Ltd | Administrative & support | 2017 |
| Spiritus Consultancy Solutions Limited | Administrative & support | 2013 |
| Spka Limited | Hospitality | 2016 |
| Spliddle Limited | Other services | 2005 |
| Split and Distant Ltd | Construction | 2024 |
| Spotty Dog Consulting Limited | Wholesale & retail | 2019 |
| Spreading the Magic Limited | Information & communication | 2005 |
| Springfield Properties (Warwickshire) Ltd | Real estate | 2022 |
| Springwater Farm Holdings Ltd | Financial services | 2025 |
| Springwell Estate Ltd | Extraterritorial | 2013 |
| Sprint Infotech Ltd | Information & communication | 2020 |
| Sprinter 88 Ltd | Transport & logistics | 2023 |
| Sprogs and Logs Ltd | Education | 2021 |
| Spydy Limited | Administrative & support | 2026 |
| Squared Chem Ltd | Professional & scientific | 2022 |
| Squarem Consulting Limited | Information & communication | 2016 |
| Squire Hall Limited | Professional & scientific | 2025 |
| Squirrels Pre-School Rugby Ltd | Education | 2012 |
| Sravaniharsha Limited | Information & communication | 2017 |
| Sree Consulting Limited | Information & communication | 2012 |
| Sreeji Catering Ltd | Hospitality | 2026 |
| SRI Corp Limited | Information & communication | 2013 |
| SRI Padmavathi Solutions Limited | Information & communication | 2011 |
| Srihari Education Ltd | Education | 2025 |
| Sripan Consulting Ltd | Information & communication | 2021 |
| Sripan Properties Limited | Real estate | 2023 |
| Srkmed Limited | Health & social care | 2021 |
| SRM Europe Limited | Professional & scientific | 2017 |
| SRS Recruitment Ltd | Administrative & support | 2017 |
| SS Estate Management Limited | Real estate | 2021 |
| SS Express Ltd | Transport & logistics | 2025 |
| SS26 Ltd | Wholesale & retail | 2025 |
| SSB Consulting Limited | Information & communication | 2020 |
| SSC Refrigeration Ltd | Manufacturing | 2024 |
| Ssgh Investments Ltd | Real estate | 2026 |
| SSK IT Consulting Ltd | Information & communication | 2018 |
| Ssmm UK Ltd | Transport & logistics | 2025 |
| SSP Consultancy Services Ltd | Information & communication | 2025 |
| Ssreddy Ltd | Information & communication | 2017 |
| ST Andrews Day Nursery Limited | Education | 2008 |
| ST Martins Court Management (NO 3) Limited | Households | 1994 |
| ST Mary's Nursing Home Limited | Health & social care | 2017 |
| ST Networks Technologies Limited | Information & communication | 2019 |
| ST. Saviours Consultancy Ltd | Professional & scientific | 2021 |
| Stab Consult Limited | Professional & scientific | 2014 |
| Stable Jack Systems Ltd | Manufacturing | 2024 |
| Stabletech Consult Ltd | Information & communication | 2018 |
| Stae Consultancy Limited | Information & communication | 2021 |
| Stae Properties Limited | Real estate | 2021 |
| Staff River Ltd | Administrative & support | 2026 |
| Staffordshire & Warwickshire Cleaning Services Limited | Administrative & support | 2013 |
| Staffzilla Group Ltd | Administrative & support | 2023 |
| Staffzilla Ltd | Administrative & support | 2021 |
| Stalwart Communications Ltd. | Professional & scientific | 2024 |
| Stanbridge Motors (Rugby) Limited | Wholesale & retail | 2011 |
| Stand in Ltd | Households | 2024 |
| Standard British Chemicals Limited | Manufacturing | 2016 |
| Standart Music Ltd | Information & communication | 2025 |
| Staple & Sons Ltd | Construction | 2021 |
| Star Bloodstock Limited | Agriculture & fishing | 2014 |
| Star Computer Services (UK) Limited | Wholesale & retail | 1993 |
| Star Fastfood Rugby Limited | Hospitality | 2025 |
| Star Investments (Midlands) Limited | Real estate | 2021 |
| Starborough Investments Limited | Households | 2020 |
| Starborough Properties Limited | Real estate | 2015 |
| Starcrypton Ltd | Information & communication | 2025 |
| Starfire Computer Consultants Ltd | Information & communication | 2021 |
| Starfire Technologies Limited | Information & communication | 1995 |
| Starglaze Home Improvements LLP | | 2009 |
| Starktech Digital Ltd | Information & communication | 2016 |
| Starla Contracts Ltd | Transport & logistics | 2025 |
| Starlight Creative Management Ltd | Professional & scientific | 2026 |
| Start Grow Sell Ltd | Information & communication | 2021 |
| Stately Powder Coating Ltd | Manufacturing | 2025 |
| Stately Powder Coating Services Ltd | Manufacturing | 2018 |
| Staybaseuk Ltd | Households | 2025 |
| Stealth Hand Ltd | Financial services | 2020 |
| Stearn Meadows Management Company Limited | Households | 2022 |
| Stefan Caprici Driving Service Ltd | Transport & logistics | 2016 |
| Stefan High Tech Interiours Ltd | Construction | 2014 |
| Steki 36 Ltd | Hospitality | 2020 |
| Stella Benson Ltd | Wholesale & retail | 2025 |
| Stellant Ventures Limited | Administrative & support | 2008 |
| Stellarpm (Europe) Limited | Manufacturing | 2022 |
| Stemspiration CIC | Professional & scientific | 2026 |
| Step Energy Limited | Construction | 2022 |
| Stephen Brown Business Development Consultancy Ltd | Professional & scientific | 2026 |
| Stepnell Developments Limited | Construction | 2025 |