| Sky Cloud Hosting Limited | Information & communication | 2014 |
| Skyfarer Ltd | Transport & logistics | 2019 |
| Skyrah Ltd | Wholesale & retail | 2025 |
| Skyrose Estates Limited | Real estate | 2002 |
| Skytrec Limited | Transport & logistics | 2016 |
| SL Construction & Landscaping Limited | Construction | 2025 |
| SL Takeaway Ltd | Hospitality | 2025 |
| SL10 Ltd | Wholesale & retail | 2020 |
| Slashtag Limited | Health & social care | 2014 |
| SLAV2000 Ltd | Transport & logistics | 2022 |
| Slavic Gospel Association (British Section) Limited | Health & social care | 1969 |
| Sleepy Seagull Ltd | Real estate | 2026 |
| Slioch Drivers Limited | Transport & logistics | 2014 |
| SLR Associates Ltd | Information & communication | 2019 |
| SM Software Solutions Ltd | Information & communication | 2019 |
| Smackshot Limited | Arts & recreation | 2025 |
| Small World Systems Limited | Information & communication | 2003 |
| Smart Alarm Services Ltd | Administrative & support | 2026 |
| Smart Business Bubble Limited | Education | 2012 |
| Smart Cargo Solutions Ltd | Transport & logistics | 2023 |
| Smart Club Software Ltd | Information & communication | 2023 |
| Smart Drain UK Limited | Water & waste | 2015 |
| Smart Haulage Solutions Limited | Transport & logistics | 2025 |
| Smart IP Services Limited | Information & communication | 2018 |
| Smart Pubs & Bars Ltd | Hospitality | 2020 |
| Smart Structural Solutions UK Ltd | Construction | 2025 |
| Smartedge Learning & IT Ltd | Information & communication | 2026 |
| Smarter Home Insulations Limited | Construction | 2012 |
| Smartflow LAB Ltd | Information & communication | 2026 |
| Smartlet Vision Ltd | Real estate | 2019 |
| Smita Engineering Services Limited | Professional & scientific | 2017 |
| Smithsec Ltd | Manufacturing | 2024 |
| SMY Leisure Ltd | Hospitality | 2002 |
| SN Group of Companies Ltd | Hospitality | 2025 |
| SNG Communications Limited | Professional & scientific | 2021 |
| Snikitha Properties Ltd | Real estate | 2022 |
| Snithi Solutions Limited | Information & communication | 2014 |
| SNP Acharya Ltd | Health & social care | 2023 |
| SNR Acoustics Ltd | Professional & scientific | 2026 |
| Sobecki’S Ltd | Administrative & support | 2025 |
| Sober Souls Ltd | Arts & recreation | 2025 |
| Soccerskillsonline Limited | Arts & recreation | 2023 |
| Socka Lawford Road Ltd | Wholesale & retail | 2025 |
| Socka Rugby Leicester Ltd | Wholesale & retail | 2025 |
| Sofeneth Limited | Health & social care | 2017 |
| Soft Step Solutions Ltd | Professional & scientific | 2019 |
| Softdrive Limited | Information & communication | 2013 |
| Softech London Limited | Information & communication | 2014 |
| Softpac Solutions Limited | Information & communication | 2015 |
| Sohalz Ltd | Transport & logistics | 2025 |
| Soko Advocates Limited | Health & social care | 2020 |
| SOL Fruits Ltd | Wholesale & retail | 2025 |
| Solar Adventure Ltd | Wholesale & retail | 2025 |
| Solar Nonwovens Limited | Manufacturing | 2002 |
| Solar Sense Skin Care Ltd | Manufacturing | 2025 |
| Solarprimeuk Ltd | Construction | 2024 |
| Sold Secure 2000 Limited | Professional & scientific | 1999 |
| Sold Secure Limited | Professional & scientific | 1999 |
| Solid Chefs Ltd | Administrative & support | 2019 |
| SOLID8 Consulting Limited | Professional & scientific | 2013 |
| SOLID8 Micro Limited | Professional & scientific | 2018 |
| Solstice Coffee Shop and Nursery Ltd | Wholesale & retail | 2020 |
| Solutions Hive Pro Ltd | Information & communication | 2025 |
| Solux Plumbing Limited | Construction | 2015 |
| Somers Property Limited | Real estate | 2022 |
| Somers Road Management Company Limited | Households | 2014 |
| Something New Enterprises Ltd | Hospitality | 2022 |
| Something of Value Limited | Professional & scientific | 2016 |
| Somii Ltd | Wholesale & retail | 2025 |
| Song Finder Group Ltd | Wholesale & retail | 2025 |
| Sonny Property Estates Limited | Real estate | 2021 |
| Sophie Cotton Limited | Professional & scientific | 2013 |
| Sophisticated Weddings Ltd | Other services | 2014 |
| Sophisticut TOO Limited | Administrative & support | 2003 |
| Soulmak Limited | Wholesale & retail | 2025 |
| Sound Insulations Ltd | Wholesale & retail | 2019 |
| Sounds to Life Ltd | Education | 2026 |
| Soundtronics Ltd | Manufacturing | 2016 |
| Sourced Fashion Ltd | Wholesale & retail | 2022 |
| South Hams Holidays Ltd | Hospitality | 2021 |
| South Warwick Construction Ltd | Construction | 2019 |
| South Warwickshire Local Food Community Interest Company | Education | 2010 |
| South West Car Repairs Ltd | Wholesale & retail | 2011 |
| Southam Country Stores Limited | Wholesale & retail | 1988 |
| Southam Estates Limited | Real estate | 2017 |
| Southcrest Transport Ltd | Transport & logistics | 2026 |
| Southfield Construction (Rugby) Ltd | Construction | 2022 |
| Southfield Property Management Ltd | Real estate | 2018 |
| Sovereign Active Investment Limited | Other services | 2014 |
| SP Foodies Ltd | Hospitality | 2026 |
| SP Gardening and Properties Services Ltd | Administrative & support | 2025 |
| Spacey's Technology Services Limited | Information & communication | 2012 |
| Span Houses Ltd | Construction | 2023 |
| Spark and Wave Audio Ltd | Information & communication | 2023 |
| Spark Learning Limited | Education | 2020 |
| Sparktech Solutions Limited | Information & communication | 2012 |
| Sparta Titan Ltd | Transport & logistics | 2025 |
| Spartan Ventures Ltd | Real estate | 2011 |
| SPB IT Consulting Ltd | Information & communication | 2018 |
| Special Educational Needs Supply Agency Limited | Education | 2023 |