| SBT Property Portfolio Ltd | Real estate | 2018 |
| SC Roofing & Cladding Ltd | Construction | 2018 |
| SC Testing Solutions Limited | Information & communication | 2021 |
| SC Yorks Ltd | Wholesale & retail | 2024 |
| Scales Automotive Group Ltd | Wholesale & retail | 2025 |
| Scanforge Ltd | Professional & scientific | 2025 |
| Scarlett Property & Developments Ltd | Construction | 2022 |
| Scavelli Properties Ltd | Construction | 2023 |
| Scent Haus Ltd | Wholesale & retail | 2025 |
| Schawnce Engineering Limited | Professional & scientific | 2004 |
| Scholars Place RTM Company Limited | Households | 2023 |
| Scholes Electrical Services Limited | Construction | 2011 |
| Scholes Investments Limited | Extraterritorial | 2013 |
| Scholes Plumbing & Heating Services Ltd | Construction | 2003 |
| School House Media Ltd | Professional & scientific | 2025 |
| Scientific Support Services Ltd | Professional & scientific | 2002 |
| SCM Externals Ltd | Wholesale & retail | 1998 |
| Scope LC Ltd | Health & social care | 2023 |
| Scotmac Limited | Wholesale & retail | 2009 |
| Scott Stevens Plumbing & Heating Limited | Construction | 2022 |
| Scotts Plumbing & Heating (Yorkshire) Ltd | Construction | 2023 |
| SD Vehicle Group Ltd | Administrative & support | 2025 |
| SDK Global Ltd | Wholesale & retail | 2016 |
| SDK9 Ltd | Administrative & support | 2025 |
| SDS Security Services Limited | Professional & scientific | 2003 |
| SDW Decorators Ltd | Construction | 2025 |
| SE Consulting Services Ltd | Information & communication | 2024 |
| Search Fuel Ltd | Information & communication | 2024 |
| Searle Roofclad Limited | Construction | 2019 |
| Seaton Park Ltd. | Construction | 2002 |
| Seavangardia Ltd | Real estate | 2025 |
| Second Avenue Care Limited | Real estate | 2022 |
| Second Millennium Fireworks Limited | Wholesale & retail | 1998 |
| Securex Technology Ltd | Manufacturing | 2015 |
| Securo Limitied Limited | Financial services | 2022 |
| Sed-Uk Ltd | Wholesale & retail | 2013 |
| Seeka Holdings Ltd | Real estate | 2025 |
| SEG (Whiston) Ltd | Real estate | 2025 |
| Segura IT Solutions Ltd | Information & communication | 2020 |
| SEJ Foods Ltd | Hospitality | 2024 |
| Selbor Holdings Ltd | Real estate | 2025 |
| Select Taxi Solutions Ltd | Transport & logistics | 2024 |
| Select Teachers Ltd | Education | 2024 |
| Select US Limited | Construction | 2021 |
| Seleste Sleep Limited | Wholesale & retail | 2025 |
| Self Assessment Express Ltd | Professional & scientific | 2019 |
| Selfsure Mobility & Bathrooms Limited | Wholesale & retail | 2023 |
| Sell & Switch Ltd | Wholesale & retail | 2025 |
| Selme Limited | Wholesale & retail | 2025 |
| Selrac Limited | Wholesale & retail | 2024 |
| Selractravels Ltd | Transport & logistics | 2025 |
| Selter Rock Limited | Real estate | 2025 |
| Selvasri Construction Ltd | Construction | 2025 |
| Selvasri Property Ltd | Real estate | 2025 |
| Selwyn Mini Market Ltd | Wholesale & retail | 2025 |
| Sendfast Logistics Limited | Transport & logistics | 2023 |
| Senex Engineering Limited | Manufacturing | 2011 |
| Senfineco Ltd | Information & communication | 2015 |
| Senior Interior Ltd | Construction | 2020 |
| Sensis Lettings Limited | Real estate | 2014 |
| Sensis Maintenance Ltd | Administrative & support | 2019 |
| Sensis Solutions Ltd | Administrative & support | 2025 |
| Seon Design Ltd | Professional & scientific | 2013 |
| Seoulful Rolls Ltd | Hospitality | 2024 |
| Sequence AI Limited | Information & communication | 2023 |
| Sequence X Ltd | Professional & scientific | 2018 |
| SER Cafe Ltd | Hospitality | 2018 |
| Serenity (South Yorkshire) Community Interest Company | Education | 2007 |
| Serenity Care Haven Ltd | Health & social care | 2024 |
| SERENITYS66 Limited | Wholesale & retail | 2022 |
| Serenterprise Properties Limited | Real estate | 2016 |
| Serious About Business Ltd | Administrative & support | 2023 |
| Serious Security Systems Limited | Administrative & support | 2017 |
| Serl Holdings Limited | Financial services | 2019 |
| Servatius Healthcare CIC | Health & social care | 2022 |
| Services and Renting Machines Ltd | Administrative & support | 2020 |
| SET About Limited | Information & communication | 2013 |
| SET Shuttle Ltd | Transport & logistics | 2026 |
| Seven Clouds Logistics Ltd | Transport & logistics | 2023 |
| Seven Hills Electrical Ltd | Construction | 2007 |
| Seven Hills Search Limited | Information & communication | 2022 |
| Sevensmiths Consulting Limited | Information & communication | 2016 |
| Sevico Solution Limited | Construction | 2025 |
| Sewerworx Limited | Water & waste | 2024 |
| SF Joinery Limited | Construction | 2013 |
| SFN Health Care Limited | Health & social care | 2022 |
| SG Auto Traders Limited | Wholesale & retail | 2025 |
| SG Medics Limited | Professional & scientific | 2020 |
| SG Nadeem Holdings Limited | Professional & scientific | 2026 |
| SG Pharma UK Limited | Wholesale & retail | 2018 |
| SG Tsco Services Limited | Public administration | 2021 |
| Sgds Automobiles Ltd | Wholesale & retail | 2025 |
| Sgiles Associates Ltd | Health & social care | 2022 |
| SGU Entertainment Ltd | Hospitality | 2023 |
| SGW Logistics Ltd. | Transport & logistics | 2016 |
| SH Inns Ltd | Hospitality | 2024 |
| SH Medical Ltd | Health & social care | 2018 |
| SH Medicine Ltd | Health & social care | 2024 |
| SHA Barbers Warrington Ltd | Other services | 2025 |
| Shabs 13 Limited | Households | 2024 |