| Shade Care Limited | Health & social care | 2021 |
| Shade Clothing Ltd | Wholesale & retail | 2025 |
| Shadow Investment Holdings Ltd | Financial services | 2024 |
| Shadow Investment Properties Ltd | Real estate | 2024 |
| Shafpharm Ltd | Wholesale & retail | 2009 |
| Shah Boys Transport Ltd | Transport & logistics | 2024 |
| Shah Finance Ltd | Administrative & support | 2016 |
| Shah JEE Travels Limited | Administrative & support | 2016 |
| Shah Partners Limited | Financial services | 2015 |
| Shahi Grill Ltd | Hospitality | 2024 |
| Shahj UK Ltd | Wholesale & retail | 2012 |
| Shahjahan (Rotherham) Ltd | Wholesale & retail | 2015 |
| Shalesmoor Steel Ltd. | Manufacturing | 1987 |
| Shalwy Properties Limited | Real estate | 2016 |
| Shan Estates Ltd | Real estate | 2021 |
| Shane Wright Sports Ltd | Education | 2023 |
| Shannice Trucare Services Limited | Administrative & support | 2026 |
| Shannon Brennan Ltd | Administrative & support | 2024 |
| Shannon Tart Extensions Ltd | Other services | 2025 |
| Sharkeye Wheel Aligners UK Ltd | Manufacturing | 2015 |
| Sharp Water Service Ltd | Manufacturing | 2014 |
| Sharpline Deburring Ltd | Manufacturing | 2026 |
| Sharrie Wilson Ltd | Other services | 2023 |
| Sharuja Ltd | Hospitality | 2025 |
| Shaun Cousins Wealth Management Limited | Professional & scientific | 2008 |
| Shaun Wilson AVE Limited | Extraterritorial | 2013 |
| Shauns Yellowbird Ltd | Hospitality | 2021 |
| Shaw Integrated Systems Ltd | Construction | 2026 |
| Shawford Developments Limited | Construction | 2021 |
| Shawford Firestopping Limited | Public administration | 2026 |
| Shawford Interiors Limited | Construction | 2018 |
| Shawford Joinery Limited | Construction | 2025 |
| Shaws Auto Centre Limited | Wholesale & retail | 2009 |
| Shaws for Sheds Limited | Manufacturing | 2002 |
| Shcf Transport Engineering Ltd | Wholesale & retail | 2024 |
| Shearings Transport Ltd | Administrative & support | 2021 |
| Shearings Travel Limited | Administrative & support | 1999 |
| Shearstone Holdings Ltd | Professional & scientific | 2017 |
| Sheba Finance Ltd | Households | 2025 |
| Shed N Fence Clowne Limited | Manufacturing | 2024 |
| Shed N Fence Ltd | Manufacturing | 2017 |
| Sheffield Business Systems Limited | Information & communication | 2006 |
| Sheffield Diocesan Board of Finance | Other services | 1924 |
| Sheffield Eats Limited | Wholesale & retail | 2022 |
| Sheffield Electronics Limited | | 1985 |
| Sheffield International Services Limited | Professional & scientific | 2011 |
| Sheffield Kitchen Outlet Ltd | Manufacturing | 2009 |
| Sheffield Motorhomes Ltd | Wholesale & retail | 2016 |
| Sheffield Steam & Vintage Club Limited | Arts & recreation | 2009 |
| Sheffmed Holdings Limited | Financial services | 2022 |
| Sheffmed Limited | Manufacturing | 2000 |
| Shefftaxi Limited | Transport & logistics | 2016 |
| Sheltermanager Ltd | Information & communication | 2012 |
| Shelutions Urban Furniture Limited | Manufacturing | 2017 |
| Sheppard Builders (SY) Ltd | Construction | 2016 |
| Sheppard Property Rentals and Services Limited | Financial services | 2023 |
| Shifah Ltd | Health & social care | 2016 |
| Shift Associates Ltd | Professional & scientific | 2011 |
| Shillito Executive Search Ltd | Professional & scientific | 2023 |
| Shine Cleaning Services (Waverley) Limited | Administrative & support | 2019 |
| Shiny Shaw Ltd | Wholesale & retail | 2025 |
| Ship Hill Taverns Ltd | Hospitality | 2019 |
| Shire Kitchen Makeovers Limited | Construction | 2016 |
| Shires Developments (Roundwood) Limited | Mining & quarrying | 2007 |
| Shivron Group Ltd | Construction | 2025 |
| Shocare Health Ltd | Health & social care | 2015 |
| Shoparound Finance Limited | Financial services | 2009 |
| Shopshop Elegant Ltd | Wholesale & retail | 2022 |
| Shor Bazaar Limited | Professional & scientific | 2014 |
| Shore Thing Holiday Lets Limited | Hospitality | 2019 |
| Shortferry Properties Limited | Real estate | 2018 |
| Shotblast Limited | Manufacturing | 2024 |
| Shotblast Technology Ltd | Manufacturing | 2011 |
| Shots of Valour Ltd | Manufacturing | 2026 |
| Showmans Access and Inspection Services Ltd | Professional & scientific | 2017 |
| Showstands Limited | | 1976 |
| Showtime Entertainment Management Ltd | Arts & recreation | 2012 |
| SHR Group Ltd | Administrative & support | 2015 |
| Shri Healthcare PVT Ltd | Health & social care | 2019 |
| Shrogswood Consulting Limited | Professional & scientific | 2013 |
| Shuttout Ltd | Information & communication | 2016 |
| Si-Co Services Ltd | Transport & logistics | 2016 |
| Siamatildagbekie Limited | Health & social care | 2020 |
| Sicilian Takeaway Limited | Hospitality | 2015 |
| Sick Fade 7 Ltd | Other services | 2026 |
| Side Delivery Ltd | Wholesale & retail | 2024 |
| Sidhu Construction and Development Limited | Construction | 2025 |
| Sidoniaphysio Ltd | Other services | 2023 |
| SIE Nails Bar Ltd | Other services | 2026 |
| Sienk Marketing & Investment Ltd | Professional & scientific | 2024 |
| Sienna Renovations Ltd | Real estate | 2024 |
| Sienna Wind Ltd | Professional & scientific | 2024 |
| Siennascarlett Ltd | Administrative & support | 2022 |
| Sifa Lettings Ltd | Real estate | 2023 |
| Sifomen Limited | Wholesale & retail | 2025 |
| Sigma-Gen Ltd | Real estate | 2019 |
| Sign OFF Pro Ltd | Construction | 2025 |
| Signal RAF Limited | Construction | 2013 |
| Signal TM Ltd | Construction | 2024 |
| Signature Floor Coverings Ltd | Wholesale & retail | 2016 |