| SA Construction (Yorkshire) Limited | Construction | 2023 |
| SA Fire Doors Ltd | Construction | 2018 |
| SA Property Developments Ltd | Real estate | 2021 |
| Sa&I Properties Ltd | Real estate | 2022 |
| Saads Pharma Locum Ltd | Health & social care | 2021 |
| Saaishankars Ltd | Wholesale & retail | 2018 |
| Saan Homes Ltd | Real estate | 2024 |
| Saas UK Services Ltd | Wholesale & retail | 2022 |
| SAB Construction (Rotherham) Limited | Construction | 2021 |
| Sabir Cabs Ltd | Transport & logistics | 2013 |
| Sablenco Ltd | Professional & scientific | 2019 |
| Sabw Limited | Other services | 2010 |
| SAF Prestige Cars Ltd | Wholesale & retail | 2021 |
| Safa Training & Consultancy Ltd | Public administration | 2016 |
| Safa-Hazel Limited | Real estate | 2023 |
| Safe Build Developments Ltd. | Construction | 2001 |
| Safe Secure Maintenance Ltd | Construction | 2001 |
| Safekey Estates Ltd | Real estate | 2023 |
| Safekey Property Ltd | Real estate | 2016 |
| Safetax Solutions Ltd | Professional & scientific | 2022 |
| Safety & Wellbeing Consultancy Services Limited | Professional & scientific | 2017 |
| Safety 1ST Driving Academy Community Interest Company | Education | 2012 |
| Safety Access Ltd | Construction | 2022 |
| Safhus Holdings Limited | Real estate | 2025 |
| Sahil Bramley Ltd | Hospitality | 2026 |
| Said Adil Limited | Wholesale & retail | 2025 |
| Saifaa Ltd | Manufacturing | 2020 |
| Saifs Boxing & Fitness Gym CIC | Arts & recreation | 2021 |
| Sait Systems & Trading Limited | Water & waste | 2004 |
| SAJ Grill & Kebab Limited | Hospitality | 2024 |
| SAK Retail Store Ltd | Real estate | 2026 |
| SAL Skin Care Ltd | Other services | 2023 |
| Sal's Dream Cars Ltd | Wholesale & retail | 2021 |
| Salem Rotherham Limited | Health & social care | 2016 |
| Salem Supplies Limited | Real estate | 2025 |
| Salento Holdings Ltd | Wholesale & retail | 2020 |
| Sales EVO Ltd | Professional & scientific | 2023 |
| Salex HR Limited | Professional & scientific | 2014 |
| Salford Holdings Ltd | Real estate | 2021 |
| Salford Lettings Ltd | Real estate | 2026 |
| Salhaayed Limited | Education | 2024 |
| Salts Mill Ltd | Real estate | 2022 |
| Saltys Touch Limited | Administrative & support | 2022 |
| Salus Controls PLC | Wholesale & retail | 2004 |
| Salus Protect Limited | Manufacturing | 2022 |
| Salvageprt Ltd | Wholesale & retail | 2025 |
| SAM Green Ltd | Construction | 2019 |
| SAM Walker Table Tennis Ltd | Arts & recreation | 2023 |
| Sam's Developments Ltd | Financial services | 2020 |
| Sam-Olivia Properties Ltd | Real estate | 2024 |
| Samahni Foods Ltd | Hospitality | 2025 |
| Samanthawell Limited | Health & social care | 2024 |
| Samartra Application Solutions Ltd | Information & communication | 2021 |
| Same Day Emergency Plumber Ltd | Construction | 2025 |
| Same-Page Ltd | Professional & scientific | 2011 |
| Sameda Limited | Other services | 2021 |
| Samyou Ltd | Real estate | 2025 |
| Sanderson Building Services Limited | Construction | 2004 |
| SANDHAZ@9 Ltd | Wholesale & retail | 2020 |
| Sandhill Computer Services Limited | Information & communication | 1986 |
| Sandhill Consultants Limited | Information & communication | 1989 |
| Sandstone House Care Limited | Health & social care | 2025 |
| Sandy Telecomunications Ltd | Construction | 2021 |
| Sanincision Surgical Ltd | Health & social care | 2025 |
| Sanitary and Construction Depot Limited | Wholesale & retail | 2025 |
| Sanjee DLA Private Ltd | Wholesale & retail | 2025 |
| Sans Travel Ltd | Administrative & support | 2023 |
| Santandre Limited | Professional & scientific | 2000 |
| Saqib Engineering Ltd | Professional & scientific | 2024 |
| SAR Vending Limited | Wholesale & retail | 2011 |
| Sara Consult Ltd | Professional & scientific | 2024 |
| Sarah Opticals Limited | Other services | 2017 |
| Sarah's Home Cleaning Services Ltd | Administrative & support | 2022 |
| Saramc Limited | Wholesale & retail | 2022 |
| Saravia D. Cleaning Services Ltd | Administrative & support | 2024 |
| Sarclad Limited | Manufacturing | 2000 |
| Sargent Homes Ltd | Real estate | 2025 |
| Sargent Serviced Accommodation Ltd | Hospitality | 2024 |
| Sari Ogullari Ltd | Hospitality | 2020 |
| SAS Surveying Ltd | Professional & scientific | 2025 |
| Sash Leisure Limited | Wholesale & retail | 2022 |
| Sash Management Limited | Professional & scientific | 2023 |
| SAT City Aerial and Satellite Services Ltd | Construction | 2025 |
| Savage Motorsport Apparel Ltd | Wholesale & retail | 2025 |
| Save Care & Support Limited | Health & social care | 2023 |
| Save Haven Enterprise Limited | Professional & scientific | 2025 |
| Saviour Nutrition Limited | Wholesale & retail | 2020 |
| Saviour Pharma Limited | Professional & scientific | 2024 |
| SAW Packaging Limited | Administrative & support | 2021 |
| Saxon Powerhouse Gym Limited | Arts & recreation | 2026 |
| Saxon Powerhouse Holdings Limited | Financial services | 2026 |
| Saxon Risk Management Ltd | Administrative & support | 2023 |
| Saxon Roofing & Properties Ltd | Construction | 2018 |
| Saxon Roofing & Sons Ltd | Construction | 2020 |
| Sayf International Ltd | Wholesale & retail | 2024 |
| SB Security Systems Limited | Construction | 2002 |
| SBD Apparel Limited | Manufacturing | 2013 |
| SBD Group Limited | Financial services | 2017 |
| SBD UK Tools and Outdoor Holdings Limited | Financial services | 2022 |
| SBM Brickworks Limited | Construction | 2019 |