| Socksville Ltd | Wholesale & retail | 2020 |
| Sodagar Ltd | Wholesale & retail | 2023 |
| Sofiah Bakes Ltd | Hospitality | 2024 |
| Softlanders.Co.Uk Limited | Health & social care | 2025 |
| Softy Delight Limited | Wholesale & retail | 2026 |
| Sohilia Ltd | Real estate | 2024 |
| Soira Labs Ltd | Information & communication | 2025 |
| Soiron Ltd | Wholesale & retail | 2025 |
| Sol'Ace (NW) Ltd | Health & social care | 2022 |
| Solchris Homes Ltd | Hospitality | 2025 |
| Soldiers Have Rights TOO Ltd | Extraterritorial | 2025 |
| Sole Theory Ltd | Wholesale & retail | 2025 |
| Solestone AI Business Solutions Ltd | Information & communication | 2023 |
| Solomons Construction Group Ltd | Construction | 2023 |
| Solomons Kitchen Limited | Hospitality | 2026 |
| Solstar Europe Limited | Professional & scientific | 2005 |
| Solstar Holdings Limited | Financial services | 2023 |
| Soltec Solar Ltd | Construction | 2024 |
| Solution Tribe Limited | Administrative & support | 2022 |
| Soma Property Group Ltd | Construction | 2025 |
| Sonaf Ecommerce Ltd | Wholesale & retail | 2024 |
| Sonex UK Limited | Wholesale & retail | 2024 |
| Soothing Life Limited | Wholesale & retail | 2022 |
| Sophresh Ltd | Hospitality | 2011 |
| SOS Development Ltd | Construction | 2025 |
| SOS Elite Limited | Wholesale & retail | 2008 |
| SOS Houses Recycling and Services Ltd | Construction | 2025 |
| Souqaljamal Ltd | Wholesale & retail | 2024 |
| Source Bioscience (Healthcare) Limited | Professional & scientific | 2003 |
| Source Bioscience (Storage) Limited | Professional & scientific | 1966 |
| Sourcenza Limited | Wholesale & retail | 2025 |
| South Medicals Ltd | Other services | 2023 |
| Soutta Bury Ltd | Hospitality | 2025 |
| Soveregin Ltd | Wholesale & retail | 2024 |
| Sovereign Facility Management Ltd | Other services | 2023 |
| SP Optom Ltd | Health & social care | 2023 |
| SP2R Foods Ltd | Wholesale & retail | 2025 |
| Spa Road Hand Car Wash Ltd | Wholesale & retail | 2026 |
| Space Installations Ltd | Construction | 2024 |
| Space Property Holdings Ltd | Real estate | 2025 |
| Spaceforum Ltd | Other services | 2023 |
| Sparkle & Fresh Cleaning Services Ltd | Administrative & support | 2023 |
| Sparkle and Gleam Cleaners Limited | Households | 2019 |
| Sparkle Fairy Maids Ltd | Administrative & support | 2018 |
| Sparkling Cloud Services Ltd | Administrative & support | 2016 |
| Sparks Gymnastics Academy Limited | Other services | 2023 |
| Spartan Costruction Ltd | Construction | 2023 |
| Spartan MF Limited | Wholesale & retail | 2015 |
| Spartan MF Properties Limited | Administrative & support | 2015 |
| Spartan MF Trading Limited | Administrative & support | 2015 |
| Spartan Project Support Ltd | Real estate | 2015 |
| Spartan Scran Limited | Hospitality | 2025 |
| Spartans MCR Ltd | Wholesale & retail | 2024 |
| Special Branch Tree Surgeons Ltd | Administrative & support | 2014 |
| Specialist Individual Broking Ltd | Financial services | 2018 |
| Specialist Remedial Solutions Ltd | Construction | 2004 |
| Speciality Chemicals Limited | Professional & scientific | 1973 |
| Spector Securities Limited | Extraterritorial | 2024 |
| Spectre Real Estate Group Ltd | Real estate | 2025 |
| Speedant Ltd | Transport & logistics | 2024 |
| Speedwell Garage Ltd | Wholesale & retail | 2011 |
| Spen Enterprise Park Management Company Limited | Real estate | 2025 |
| Spencer Incorporated Ltd | Hospitality | 2025 |
| Spencerjay Construction Ltd | Construction | 2025 |
| Sperber Ltd. | Wholesale & retail | 2024 |
| SPH Legal Ltd | Professional & scientific | 2025 |
| Spice 'N' Spirits Indian Kitchen Limited | Hospitality | 2019 |
| Spice N Spirits Catering Ltd | Hospitality | 2023 |
| Spice N Spirits Curry & Hurry Ltd | Hospitality | 2023 |
| Spicy Garden Ltd | Hospitality | 2019 |
| Spicyparadiseltd Ltd | Hospitality | 2025 |
| Spider Infra Ltd | Information & communication | 2025 |
| Spinco Limited | Professional & scientific | 2008 |
| Spire Trade Limited | Information & communication | 2017 |
| Splash Plumbing and Heating (Stockport) Limited | Construction | 2009 |
| Spodden Homes Limited | Construction | 2007 |
| Sporteq Ltd | Manufacturing | 2023 |
| Sportive Ltd | Arts & recreation | 2018 |
| Spot on Computers Limited | Wholesale & retail | 2018 |
| Spotland Bridge Mills Limited | Real estate | 2016 |
| Spotland Islamic Centre Ltd | Education | 2025 |
| Spotland Properties Ltd | Households | 2024 |
| Spotland Training Limited | Education | 2026 |
| Spotlight Events Management Ltd | Hospitality | 2023 |
| Spots and Stripes Childcare Ltd | Education | 2025 |
| Spray Coating Specialist Ltd | Construction | 2026 |
| Spray Group Ltd | Wholesale & retail | 2019 |
| Spraybake JRC Ltd | Manufacturing | 2025 |
| Springfield Park Bees Community Interest Company | Hospitality | 2021 |
| Springguest Limited | Extraterritorial | 2017 |
| Springhill Hospice (Rochdale) | Health & social care | 1988 |
| Springhill Hospice (Services) Limited | Wholesale & retail | 1993 |
| Sprout 9 Ltd | Wholesale & retail | 2022 |
| Spudelicious Cafe Limited | Hospitality | 2025 |
| SQL ZEN Solutions Ltd | Professional & scientific | 2018 |
| Square Digitizing Limited | Information & communication | 2022 |
| SR Engineering Solutions Limited | Professional & scientific | 2024 |
| SR Medical Aesthetix Ltd | Other services | 2025 |
| SR Trade Ltd | Wholesale & retail | 2026 |
| SR Tyres World Ltd | Wholesale & retail | 2023 |