| Sjmitchell Inc Ltd | Professional & scientific | 2015 |
| Sjmm Properties Limited | Real estate | 2016 |
| SJN Couriers Ltd | Transport & logistics | 2022 |
| SK Fitting Service Ltd | Construction | 2023 |
| SK Glow Ltd | Other services | 2023 |
| SK Knightcare Holdings Ltd | Wholesale & retail | 2025 |
| SK Sound and Production Ltd | Information & communication | 2013 |
| SKI Trader Limited | Manufacturing | 2022 |
| Skill Centre Ltd | Public administration | 2023 |
| Skills 4 ALL Ltd | Education | 2019 |
| Skinspiration Ltd | Other services | 2017 |
| Skipping Workshops Ltd | Education | 2002 |
| SKN Boutique Limited | Wholesale & retail | 2017 |
| Sky Bay Parking Ltd | Transport & logistics | 2025 |
| Sky Career Consultants Ltd | Professional & scientific | 2023 |
| Sky Dental Ceramics Limited | Manufacturing | 2004 |
| Sky Gold Ltd | Wholesale & retail | 2025 |
| Sky Hand Car Wash Haslingden Ltd | Administrative & support | 2022 |
| Sky Plant Hire Ltd | Administrative & support | 2012 |
| Sky Seventy Ltd | Administrative & support | 2015 |
| Skylight Circus in Education | Arts & recreation | 1990 |
| Skyline Products Ltd | Wholesale & retail | 2010 |
| Skywards Travel Ltd | Administrative & support | 2011 |
| Skyways Automobile Limited | Wholesale & retail | 2025 |
| Skyways Global UK Limited | Transport & logistics | 2023 |
| Skyzelle Limited | Wholesale & retail | 2026 |
| SL Paving Ltd | Other services | 2018 |
| Slaters of Rochdale Limited | | 1957 |
| Sleek Events Hub Ltd | Administrative & support | 2025 |
| Sleek N Chique Beauty & Fashion Salon Ltd | Wholesale & retail | 2025 |
| Sleep and Beyond Limited | Wholesale & retail | 2015 |
| Sleeptightuk Ltd | Manufacturing | 2026 |
| Slipstreamshop Ltd | Manufacturing | 2025 |
| SLM Investments Limited | Real estate | 2019 |
| SLM Mortgages Limited | Financial services | 2020 |
| SLR Access Ltd | Administrative & support | 2022 |
| SLR Property Holdings Ltd | Financial services | 2025 |
| Slrb Consultants Ltd | Professional & scientific | 2025 |
| SLS Stays Ltd | Real estate | 2025 |
| SM Advocacy Ltd | Professional & scientific | 2026 |
| SM Cash & Carry Limited | Administrative & support | 2012 |
| SM Distribution(Uk) Ltd | Wholesale & retail | 2010 |
| SM Nooran Ltd | Financial services | 2022 |
| SM NUR Trading Ltd | Wholesale & retail | 2023 |
| SM Roofing Services (NW) Ltd | Construction | 2024 |
| SM Rowshan Properties Ltd | Real estate | 2025 |
| Small World Nurseries Limited | Education | 2000 |
| Smallbridgechippy Ltd | Hospitality | 2025 |
| SMALLSHAW69 Limited | Professional & scientific | 2013 |
| Smart Appliances Holding Limited | Wholesale & retail | 2016 |
| Smart Appliances Trading Limited | Wholesale & retail | 2016 |
| Smart Cars 4 U Ltd | Wholesale & retail | 2023 |
| Smart CUT Barber Shop Ltd | Other services | 2024 |
| Smart E-Commerce PVT Limited | Wholesale & retail | 2024 |
| Smart Electrical Engineers Limited | Construction | 2007 |
| Smart Homes Online Limited | Wholesale & retail | 2025 |
| Smart Money Saver Ltd | Information & communication | 2020 |
| Smart Pet Shop Ltd | Extraterritorial | 2014 |
| Smart Range Kitchens Limited | Manufacturing | 2019 |
| Smart Schoolwear Ltd | Wholesale & retail | 1993 |
| Smart Space Real Estate Ltd | Real estate | 2023 |
| Smart Tech Heating (NW) Ltd | Administrative & support | 2019 |
| Smart Trim Repairs Ltd | Wholesale & retail | 2024 |
| Smartbiservices Ltd | Information & communication | 2017 |
| Smartblaze Ltd | Hospitality | 2019 |
| Smartchoice Dental Construction Ltd | Construction | 2013 |
| Smartdealsuk Ltd | Wholesale & retail | 2026 |
| Smartlink Tech Ltd | Wholesale & retail | 2020 |
| Smash N Spice Ltd | Hospitality | 2026 |
| Smdecore Ltd | Wholesale & retail | 2024 |
| Smeaton Heating Services Limited | Construction | 2022 |
| Smile HA Ltd | Health & social care | 2024 |
| Smile High Care Ltd | Health & social care | 2023 |
| Smith and Jackson Limited | Extraterritorial | 2020 |
| Smith Meehan Limited | Real estate | 1993 |
| Smithedge Construction Services Ltd | Construction | 2007 |
| Smithedge Property Services Limited | Real estate | 2015 |
| Sml's Hope Ltd | Health & social care | 2015 |
| Smoke Cloudz Ltd | Wholesale & retail | 2019 |
| Smokoholic Bolton Limited | Wholesale & retail | 2025 |
| Smokoholic Whitworth Limited | Wholesale & retail | 2024 |
| SMR Health & Beauty Ltd | Wholesale & retail | 2020 |
| SMS by Keytech Ltd | Information & communication | 2021 |
| SN Construction & Property Management Ltd | Construction | 2023 |
| SN Motor Vehicles Ltd | Wholesale & retail | 2025 |
| SNA Distribution Limited | Administrative & support | 2025 |
| Snag Doctor Group Ltd | Construction | 2020 |
| Snag Doctor Ltd | Construction | 2017 |
| SNJ Stores Limited | Real estate | 2000 |
| Snoozio Group Ltd | Wholesale & retail | 2026 |
| Snst Ltd | Real estate | 2025 |
| SNUGASABUG13 Limited | Wholesale & retail | 2023 |
| Snuggrab Limited | Manufacturing | 2023 |
| Snuspoint Ltd | Wholesale & retail | 2021 |
| SO Nashville Leeds Ltd | Hospitality | 2024 |
| SO Social Limited | Information & communication | 2025 |
| Soccer Factory Sports Ltd | Arts & recreation | 2013 |
| Soch Studio Limited | Information & communication | 2025 |
| Sochandsail Limited | Transport & logistics | 2025 |
| Social Care North West Ltd | Health & social care | 2023 |