| Shade Dept Ltd | Wholesale & retail | 2024 |
| Shah & Sons Sussex Limited | Wholesale & retail | 2008 |
| Shaws Corner Advisory Limited | Professional & scientific | 2017 |
| Sheen Property Management Limited | Extraterritorial | 2006 |
| Shell CAD Design Limited | Professional & scientific | 2023 |
| Shell Design & Construction Ltd | Construction | 2021 |
| Shell Developments Limited | Financial services | 2024 |
| Shemyro Ltd | Real estate | 2019 |
| Shenfield House RTM Company Limited | Households | 2023 |
| Shenorock Ltd | Professional & scientific | 2015 |
| Sheridan Adams Investments Ltd | Real estate | 2019 |
| Sheridan Adams Properties Ltd | Real estate | 2019 |
| Sheridan Gold LLP | | 2010 |
| SHF Accountancy Limited | Professional & scientific | 2020 |
| Ship Fast 2 UK Ltd | Transport & logistics | 2021 |
| Shipley Bridge Garage MOT Ltd | Wholesale & retail | 2025 |
| Shirley Palmer International Enterprises Limited | Professional & scientific | 2018 |
| Shirt Mill Limited | Wholesale & retail | 2015 |
| Shoreline Medics Ltd | Health & social care | 2025 |
| Shortlets UK Limited | Real estate | 2002 |
| Shrivinayak SAN Limited | Wholesale & retail | 2023 |
| Shuttleworth Consulting Services Ltd | Professional & scientific | 2014 |
| Siam Fitness Centre Ltd | Arts & recreation | 2010 |
| Sichuan Cottage Ltd | Professional & scientific | 2019 |
| Silver Birches (Shelvers Way) Tadworth, Surrey, Management Company Ltd | Households | 2024 |
| Silverlea Developments Ltd | Real estate | 2022 |
| Silverlee Doggy Day Care Limited | Other services | 2015 |
| Simmway IT Solutions Ltd | Information & communication | 2013 |
| Simon Block Limited | Arts & recreation | 2006 |
| Simon Ellis Associates Ltd | Professional & scientific | 2012 |
| Simply Social Limited | Professional & scientific | 2025 |
| Simply Tanning Ltd | Administrative & support | 2019 |
| Simpsons Homecare Limited | Health & social care | 2024 |
| Singcat Medical Consultancy Limited | Professional & scientific | 2010 |
| Sinhsang Ltd | Hospitality | 2018 |
| Siren Digital Limited | Professional & scientific | 2013 |
| Sitemaster Limited | Professional & scientific | 1994 |
| Sitta Limited | Hospitality | 1997 |
| Sixmile Developments (Reigate) Limited | Construction | 2012 |
| Sizzling WOK Hampshire Ltd | Hospitality | 2024 |
| SJD HR Consultancy Ltd | Administrative & support | 2018 |
| SJS HR Consultancy and Interim Services Limited | Professional & scientific | 2016 |
| SK London Service Ltd | Professional & scientific | 2024 |
| SKH Consultancy Services Ltd | Professional & scientific | 2015 |
| Skiing DOO Ltd | Hospitality | 2025 |
| Skimmington Castle Ltd | Hospitality | 2026 |
| Skinflow Ltd | Wholesale & retail | 2019 |
| Skinvibes Limited | Health & social care | 2025 |
| Skitch Media Limited | Information & communication | 2017 |
| Sky Capital Investments Ltd | Real estate | 2018 |
| Skycliq Limited | Other services | 2020 |
| Skyland Tourism Limited | Other services | 2018 |
| Skylarks (Rottingdean) Management Company Limited | Households | 2022 |
| Skylight Services (UK) Limited | Construction | 2012 |
| Skymaster (2010) Ltd | Arts & recreation | 2011 |
| Skytrade (International) Limited | Wholesale & retail | 1999 |
| Sladen Consultancy Limited | Professional & scientific | 2001 |
| Slater & Truter Limited | Professional & scientific | 2020 |
| SLG Bespoke Limited | Manufacturing | 2022 |
| Sloane Avenue & Co Ltd | Construction | 2025 |
| SLP London Limited | Construction | 2010 |
| Small & Round Ltd | Manufacturing | 2020 |
| Small Business Solutions (UK) Limited | Information & communication | 2006 |
| Smallworld Projects Limited | Construction | 2013 |
| Smart Play UK Ltd | Construction | 2026 |
| Smart Side Limited | Information & communication | 2016 |
| Smartdial Limited | Information & communication | 2000 |
| Smartsec Ltd | Information & communication | 2025 |
| Smarttech DCC Ltd | Construction | 2023 |
| SMC Electrical Limited | Manufacturing | 2017 |
| Smith Towers Ltd | Real estate | 2021 |
| Snakco Limited | Wholesale & retail | 2024 |
| Snow Clothing Hire Limited | Administrative & support | 2023 |
| Snowhill Consulting Ltd | Professional & scientific | 2024 |
| Sochance Ltd | Administrative & support | 2023 |
| Social Work Assessors Ltd | Health & social care | 2022 |
| Socz Ltd | Wholesale & retail | 2023 |
| Softech Technologies Limited | Information & communication | 2013 |
| Solanahr Staffing Recruitment Limited | Administrative & support | 2023 |
| Solar Lounge Tanning Ltd | Wholesale & retail | 2017 |
| Solartee Limited | Information & communication | 2013 |
| Sollo Ltd | Wholesale & retail | 2019 |
| Solotel Limited | Information & communication | 2016 |
| Sonin Ltd | Information & communication | 2019 |
| Sophie Griffiths Architects Limited | Professional & scientific | 2022 |
| Sophkat Consulting Limited | Administrative & support | 2023 |
| Sotor Cars Ltd | Transport & logistics | 2025 |
| Soul Response Hypnotherapy Ltd | Health & social care | 2022 |
| Sound Heads Limited | Information & communication | 2017 |
| South East Events Limited | Other services | 2017 |
| South East Osteopaths Limited | Health & social care | 2005 |
| South Eastern Society of Chartered Accountants Limited | Other services | 1998 |
| South Lawns (Reigate) Management Company Limited | Households | 2008 |
| South Lawns Freehold Ltd | Households | 2019 |
| South Park Football Club Limited | Arts & recreation | 2017 |
| South Sutton Management Ltd | Hospitality | 2015 |
| Southern Lock & Safe Co. Ltd. | Administrative & support | 1996 |
| Southwick Fish Shop Ltd | Hospitality | 2023 |
| SP Procurement Ltd | Professional & scientific | 2022 |
| SP Psychology Ltd | Health & social care | 2022 |