| Space for Good Ltd | Professional & scientific | 2018 |
| Spada Holdings Limited | Administrative & support | 2015 |
| Spada Invest Ltd | Real estate | 2022 |
| Spada Investments LLP | | 2013 |
| Spanjer Chemicals Limited | Manufacturing | 2002 |
| Sparkactiv Ltd | Arts & recreation | 2026 |
| Sparkly Light Creative Media Limited | Information & communication | 2008 |
| Sparkly Light Productions Limited | Information & communication | 2013 |
| SPD Global Advisors Ltd | Professional & scientific | 2026 |
| Special Branch Tree Care Ltd | Other services | 2004 |
| Special Event Services Limited | Administrative & support | 1998 |
| Special Teams Limited | Financial services | 2022 |
| Specialist Recruit International Limited | Administrative & support | 2003 |
| Spencer Lawrence Limited | Arts & recreation | 2006 |
| Spencer Scott Limited | Administrative & support | 2017 |
| Spice Fork Ltd | Hospitality | 2022 |
| Spice of India (Woking) Limited | Water & waste | 2013 |
| Spidge Limited | Professional & scientific | 2007 |
| Spikyjumper Ltd | Extraterritorial | 2022 |
| Spine Energy Technology Limited | Information & communication | 2025 |
| Spire Platform Solutions Limited | Financial services | 2018 |
| Splice Editing Ltd | Information & communication | 2009 |
| Sponden Estates Limited | Professional & scientific | 2025 |
| Spook Limited | Professional & scientific | 2003 |
| Sporties Limited | Arts & recreation | 2016 |
| Spreckley Property Search Limited | Professional & scientific | 2007 |
| Sprees House T/A the Plough Ltd | Hospitality | 2023 |
| Springcopse Investments Limited | Real estate | 2018 |
| Sprint Marketing Consultancy Limited | Professional & scientific | 2007 |
| SPY Wealth Management Ltd | Professional & scientific | 2022 |
| Spyglass Properties NO.4 GP Limited | Professional & scientific | 2007 |
| Srisujihari Property Ltd | Real estate | 2025 |
| SS Cars Gatwick Limited | Transport & logistics | 2025 |
| SSH Conservation Ltd | Construction | 2025 |
| Sstring Ltd | Information & communication | 2002 |
| ST Walsh LLP | | 2008 |
| Standout Consulting Limited | Professional & scientific | 2023 |
| Stanton Construction Holding Company Limited | Real estate | 2023 |
| Stanworth Consulting Limited | Professional & scientific | 2024 |
| Star Potential Limited | Administrative & support | 2014 |
| Star Steppers Performing Arts Limited | Arts & recreation | 2010 |
| Starbrite Chemicals Limited | Wholesale & retail | 1987 |
| Stardollar Limited | Real estate | 2024 |
| Stardollar Partnership LLP | | 2024 |
| Starfish Catering Limited | Hospitality | 2018 |
| Stark & Greensmith Metalwork Ltd | Professional & scientific | 2022 |
| Start ME UP Brand Consulting Limited | Professional & scientific | 2019 |
| Stegra Ltd | Real estate | 2020 |
| Stentor Limited | Professional & scientific | 1993 |
| Stephen Aries Consulting Limited | Information & communication | 2012 |
| Stephen Catling Consultancy Services Limited | Administrative & support | 2015 |
| Stephenson and Thomas Property Limited | Real estate | 2023 |
| Sterling Build Group Limited | Construction | 2026 |
| Stern Group Developments Limited | Construction | 2019 |
| Stevenson Project Management Limited | Professional & scientific | 2001 |
| Steyning Village Stores Limited | Wholesale & retail | 2019 |
| Stillmind Ayurveda Ltd | Manufacturing | 2026 |
| Stillwater Associates Limited | Professional & scientific | 2008 |
| Stillwater Associates Trustees Limited | Professional & scientific | 2024 |
| Stitchup Tailoring Ltd | Manufacturing | 2022 |
| STM Change Management Limited | Professional & scientific | 2014 |
| Stockton Consultants Limited | Professional & scientific | 2015 |
| Stone Reigate Ltd | Real estate | 2023 |
| Stonebridge Coaching Ltd | Professional & scientific | 2026 |
| Story Cellar Limited | Hospitality | 2022 |
| Story Diner Limited | Hospitality | 2023 |
| Story GCC Limited | Hospitality | 2025 |
| Storyland Holdings Limited | Financial services | 2020 |
| Stow & Go Storage Ltd | Real estate | 2024 |
| Straight on Ltd | Construction | 2015 |
| Straker & Speed Limited | Hospitality | 2013 |
| Stralbond Limited | | 1980 |
| Stratco Limited | Professional & scientific | 2002 |
| Strategi Limited | Professional & scientific | 2007 |
| Strategy Into Action Limited | Professional & scientific | 2007 |
| Stratida Ltd | Public administration | 2025 |
| Streaky Bacon Ltd | Financial services | 2025 |
| Striveprojects Ltd | Construction | 2022 |
| Stryp Ltd | Wholesale & retail | 2025 |
| Stuart Pavey Watch & Clock Repairs Ltd | Other services | 2026 |
| Studio Boum Holdings Limited | Financial services | 2024 |
| Studio Boum Ltd | Administrative & support | 2014 |
| Studio M Architects & Interior Designers Limited | Professional & scientific | 2019 |
| Studio New Place Limited | Professional & scientific | 2021 |
| Studio Xpress Ltd | Professional & scientific | 2006 |
| STUDIO234 Limited | Arts & recreation | 2016 |
| Stylus Partners Ltd | Professional & scientific | 2025 |
| SU Family Property Limited | Real estate | 2021 |
| Sublication Limited | Construction | 2023 |
| Submitnote Projects Limited | Wholesale & retail | 1993 |
| Summer Day Media Ltd | Professional & scientific | 2017 |
| Summerhayes Research Limited | Professional & scientific | 2019 |
| Summerly Consulting Limited | Professional & scientific | 2024 |
| Summit Business Consulting Limited | Information & communication | 2012 |
| Summit Wellbeing Reigate Limited | Health & social care | 2023 |
| Sunny Eco Properties Ltd | Real estate | 2020 |
| Sunpark Holdings Ltd | Professional & scientific | 2016 |
| Sunshine Jones Ltd | Professional & scientific | 2022 |
| Sunte Park Management Company Limited | Households | 2019 |
| Suntech UK Limited | Manufacturing | 2009 |