| Smallwood Consortium Ltd | Financial services | 2024 |
| Smart Building Technology Ltd | Information & communication | 2023 |
| Smart Consultancy HR Limited | Other services | 2017 |
| Smart Electrical (Midlands) Ltd | Construction | 2018 |
| Smart Taxi Services Ltd | Transport & logistics | 2018 |
| Smart X S Limited | Professional & scientific | 2005 |
| Smarter Response Ltd | Education | 2025 |
| Smartfarms Ltd | Wholesale & retail | 2025 |
| SMC Comms Ltd | Information & communication | 2019 |
| SMC Engineering Ltd | Professional & scientific | 2026 |
| Smile and Rise Ltd | Public administration | 2022 |
| Smiths Design Group Limited | Professional & scientific | 2002 |
| Smiths Office & Commercial Furniture Limited | Wholesale & retail | 2003 |
| Smks Food & Spices Ltd | Hospitality | 2025 |
| Smoke Control Systems Ltd | Manufacturing | 2005 |
| Smoke Ventilation Controls Ltd | Manufacturing | 2013 |
| Smokepitbyjd Limited | Hospitality | 2026 |
| Smokey Dicks BBQ Limited | Hospitality | 2026 |
| SND IT Golf Ltd | Wholesale & retail | 2023 |
| Sniminal Limited | Arts & recreation | 2018 |
| SNJ Pasamonte Limited | Health & social care | 2013 |
| SNM Group Limited | Financial services | 2022 |
| SO ASK Limited | Administrative & support | 2010 |
| Sobea Consultancy Ltd | Professional & scientific | 2022 |
| Sobia & Inaaya Innovation Ltd | Professional & scientific | 2015 |
| Social Care Toolbox Limited | Information & communication | 2020 |
| Social Edge Group Ltd | Information & communication | 2022 |
| Social Network Football Limited | Information & communication | 2025 |
| Soda Claims Management Limited | Professional & scientific | 2026 |
| Sohal Property Group Limited | Extraterritorial | 2021 |
| Sohale Feroze Karak Chaii Holdings Ltd | Hospitality | 2023 |
| Solar Select Limited | Administrative & support | 2016 |
| Solar Sentry Window Films Limited | Construction | 2019 |
| Solar Slate Plate Limited | Manufacturing | 2013 |
| Solaris Electrical Limited | Construction | 2003 |
| Soleful Foot Health Ltd | Health & social care | 2025 |
| Solent View Developments LLP | | 2017 |
| Solid State PLC | Professional & scientific | 1963 |
| Solid State Supplies Limited | Wholesale & retail | 2005 |
| Solinst UK Ltd. | Wholesale & retail | 2026 |
| Solite Europe Limited | Manufacturing | 1988 |
| SOLO64 Ltd | Manufacturing | 2017 |
| Sologas Ltd | Construction | 2025 |
| Solsta Limited | Administrative & support | 2022 |
| Somerset Capital Limited | Professional & scientific | 2024 |
| Sonia Munir Ltd | Wholesale & retail | 2025 |
| Sonya Skelton Ltd | Public administration | 2024 |
| Sophia James Holdings Limited | Financial services | 2016 |
| Soul Hair Design Ltd | Other services | 2015 |
| Soul Rent a Chair Ltd | Other services | 2017 |
| Soulaud Ltd | Health & social care | 2024 |
| South Birmingham Taverns Ltd | Hospitality | 2023 |
| South West Assessment and Training GAS Services Holdings Limited | Education | 2011 |
| South West Assessment and Training GAS Services Limited | Education | 1999 |
| South West Chimney Repairs & Scaffolding Ltd. | Construction | 2017 |
| South Worcestershire (Sports) Limited | Professional & scientific | 2006 |
| Southam Garden Services Ltd. | Administrative & support | 2017 |
| Southcrest Management Limited | Other services | 2000 |
| Southcrest Properties Limited | Real estate | 2014 |
| Southcrest Veterinary Centre Limited | Professional & scientific | 2025 |
| Southern Delta | Households | 1996 |
| Southern Lets | Real estate | 1996 |
| Southern Metropolitan | Hospitality | 1979 |
| Sovereign Conference Exhibitions & Travel Incentives Ltd | Administrative & support | 2017 |
| SP Handyman Services Ltd | Construction | 2026 |
| Sparkle Tech Cleaners Ltd | Administrative & support | 2024 |
| Sparlonz Limited | Manufacturing | 2009 |
| Spatz Arlon Properties Limited | Real estate | 2006 |
| SPB Software Solutions Ltd | Information & communication | 2013 |
| Spcc Limited | Information & communication | 2002 |
| SPD Properties Ltd | Real estate | 2014 |
| SPE Limited | Administrative & support | 2001 |
| Speak for YOU Ltd | Administrative & support | 2025 |
| Spear Surveying Limited | Professional & scientific | 2022 |
| Speedaq Ltd | Real estate | 2026 |
| Speedbird Group Limited | Professional & scientific | 2021 |
| Speedbird Logistics Limited | Transport & logistics | 2021 |
| Speedfab Fabrications Ltd | Manufacturing | 2025 |
| Spencer Asquith Limited | Education | 2023 |
| Spencer Feeds (Asia) Limited | Wholesale & retail | 2021 |
| SPF Construction Ltd | Construction | 2006 |
| Spice of Redditch Limited | Hospitality | 2025 |
| Spin OFF Studios Limited | Information & communication | 2022 |
| Spitfire GAS Ltd | Construction | 2019 |
| Spitfire Machinery Ltd | Construction | 2024 |
| SPM-57. Limited | Information & communication | 2025 |
| Spoodernest Ltd | Wholesale & retail | 2021 |
| Sport Development Services Ltd | Arts & recreation | 2020 |
| Sportsmans Arms (Redditch) Ltd | Hospitality | 2024 |
| SPR Designs Midlands Limited | Manufacturing | 2016 |
| Spragg Holdings Ltd | Financial services | 2021 |
| Sprigg & Sprigg Ltd | Professional & scientific | 2024 |
| Spring Products Ltd | Manufacturing | 2021 |
| Springworks Inc Ltd | Real estate | 2021 |
| Springxpert Ltd | Wholesale & retail | 2023 |
| Spud Design Ltd | Administrative & support | 2006 |
| Spuddy Lovely Limited | Hospitality | 2025 |
| Spwm Limited | Financial services | 2015 |
| Square Nine Ltd | Wholesale & retail | 2026 |
| Square RIG Properties Limited | Real estate | 2006 |